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BDNF — RELA

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Lipsky et al., J Neurochem 2001 : Furthermore, nuclear extracts prepared from neurons treated with NMDA and the double stranded NF-kappaB oligonucleotide showed reduced DNA binding activity to the target sequence, supporting the idea that NF-kappaB may be involved in the transcriptional activation of the BDNF gene ... We also determined that BDNF itself induced an NF-kappaB DNA binding activity
Zaheer et al., Neurochem Res 2001 : The inductions of BDNF and NGF were also blocked by inhibitors of p38 and MEK, as well as by the inhibition of NF-kappaB with a decoy DNA sequence
Okuda et al., Nihon Shinkei Seishin Yakurigaku Zasshi 2002 : Neuroprotection by NMDA is mediated by a de novo synthesis of proteins such as brain derived neurotrophic factor , whose expression is activated by the transcription factor NF kappa B
Rodriguez-Kern et al., Neurochem Int 2003 : The BDNF dependent activation of NF-kappaB and up-regulation of GLT-1 was critically dependent on the upstream activation of p42/p44 MAP kinase signaling, whereas the inhibition of these MAP kinases dramatically increased the Abeta dependent activation of NF-kappaB and production of GLT-1
Furuno et al., Neurosci Lett 2006 : These results suggested that there is a close correlation between the signaling pathways via TNF receptors and neurotrophin receptors for the NF-kappaB activation, and that NGF and BDNF enhance TNF-alpha induced nuclear translocation of NF-kappaB
Fan et al., Brain Res 2006 : The purpose of the study is to determine if expression or secretion of brain derived neurotrophic factor (BDNF) in retinal ganglion cells ( RGC-5 ) is mediated by NFkappaB or Ca2+/calmodulin dependent protein kinase II ( CaMKII )
Saha et al., J Neuroimmune Pharmacol 2006 : Activation of NF-kappaB by TNF-alpha and inhibition of TNF-alpha induced BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that TNF-alpha induces BDNF expression through the activation of NF-kappaB
Zhou et al., Exp Neurol 2008 : Nuclear factor-kappaB (NF-kappaB) inhibitor ( PDTC ) also suppressed spinal BDNF-LTP
Zhang et al., Zhonghua Xue Ye Xue Za Zhi 2008 (Multiple Myeloma) : The activity of NF-kappaB was enhanced by BDNF in a dose dependent manner, and pretreatment with K252 alpha could significantly inhibit this activation at 1, 6, 12 and 24 h ( P < 0.05 ) in a time dependent manner
Kajiya et al., J Cell Physiol 2009 (Necrosis) : BDNF enhanced phosphorylated Akt levels, NF-kappaB activity in the nucleus, Bcl-2 mRNA levels, and mitochondrial membrane potential
Kairisalo et al., Eur J Neurosci 2009 : NF-kappaB dependent regulation of brain derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein ... BDNF itself activated NF-kappaB in the neurons at higher concentrations
Gavaldà et al., Development 2009 : Shortly before birth, BDNF activates NF-kappaB by an atypical mechanism that involves tyrosine phosphorylation of IkappaBalpha by Src family kinases, and dephosphorylates p65 at serine 536
Carter et al., Science 1996 : The effect was selective for NGF ; NF-kappa B was not activated by BDNF or NT-3