Gene interactions and pathways from curated databases and text-mining

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CFL1 — HSPG2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Matsui et al., Cell Signal 2001 : These results suggest that the activity and localization of cofilin are regulated by PLC at the downstream of src-family tyrosine kinase
Mouneimne et al., J Cell Biol 2004 (Carcinoma...) : Inhibition of PLC inhibits cofilin activity in cells during the early transient, delays the initiation of protrusions, and inhibits the ability of cells to sense a gradient of EGF
Mouneimne et al., Curr Biol 2006 : These results indicate that local activation of cofilin by PLC and its global inactivation by LIMK phosphorylation combine to generate the local asymmetry of actin polymerization required for chemotaxis
Ivanov et al., J Cell Sci 2008 : PLC dependent stimulation of ADF/cofilin creates actin-filament barbed ends and promotes the outgrowth of F-actin-rich protrusions