Gene interactions and pathways from curated databases and text-mining
PIK3CA: top 25 interacting genes (chr3:178866144-178957881)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only PIK3CA-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with PIK3CA, not among the Top 25
Other genes interacting with PIK3CA. Mouse-over to show number of abstracts or databases. Sorted alphabetically (sort by article count).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

ABCB1 ▸ ABI1 ▸ ABL1 ▸ ACD ▸ ACTA2 ▸ ACTBL2 ▸ ACTG2 ▸
ADAM12 ▸ ADAP1 ▸ ADAR ▸ ADORA1 ▸ ADORA3 ▸ ADRBK1 ▸ AGTR2 ▸
AHSA1 ▸ AIFM1 ▸ AKT1S1 ▸ ALDOA ▸ ALYREF ▸ AMBP ▸ AMPH ▸
ANG ▸ ANGPT1 ▸ ANGPT2 ▸ ANXA2 ▸ ANXA6 ▸ AP1M2 ▸ APLP2 ▸
APPL1 ▸ AQP3 ▸ AR ▸ ARAF ▸ ARHGEF1 ▸ ARHGEF7 ▸ ARSK ▸
ATP1A1 ▸ ATP1A3 ▸ ATP5B ▸ ATP5O ▸ ATPIF1 ▸ ATR ▸ ATXN2L ▸
B2M ▸ BAD ▸ BASP1 ▸ BAX ▸ BCAR1 ▸ BCL10 ▸ BCL2 ▸
BCL3 ▸ BCL5 ▸ BCL6 ▸ BCL9 ▸ BCR ▸ BDNF ▸ BIRC2 ▸
BMP1 ▸ BMP10 ▸ BMP15 ▸ BMP2 ▸ BMP3 ▸ BMP4 ▸ BMP5 ▸
BMP6 ▸ BMP7 ▸ BPNT1 ▸ BRAF ▸ BRCA1 ▸ BSG ▸ BTK ▸
C14orf166 ▸ C1orf228 ▸ CA2 ▸ CALM1 ▸ CALM2 ▸ CALM3 ▸ CALR ▸
CANX ▸ CASP1 ▸ CASP10 ▸ CASP12 ▸ CASP14 ▸ CASP16 ▸ CASP2 ▸
CASP3 ▸ CASP4 ▸ CASP5 ▸ CASP6 ▸ CASP7 ▸ CASP8 ▸ CASP9 ▸
CAT ▸ CAV1 ▸ CAV2 ▸ CAV3 ▸ CBFA2T2 ▸ CBL ▸ CBLB ▸
CBLC ▸ CCAR2 ▸ CCDC88A ▸ CCK ▸ CCL2 ▸ CCND1 ▸ CCND2 ▸
CCNG1 ▸ CCT5 ▸ CD14 ▸ CD19 ▸ CD2 ▸ CD247 ▸ CD28 ▸
CD38 ▸ CD3Z ▸ CD4 ▸ CD79A ▸ CD79B ▸ CD80 ▸ CD86 ▸
CDC123 ▸ CDC16 ▸ CDC20 ▸ CDC23 ▸ CDC26 ▸ CDC27 ▸ CDC34 ▸
CDC37 ▸ CDC40 ▸ CDC42 ▸ CDC45 ▸ CDC6 ▸ CDC7 ▸ CDC73 ▸
CDH1 ▸ CDH5 ▸ CDK5 ▸ CDKN1A ▸ CEBPA ▸ CEBPB ▸ CHKA ▸
CHUK ▸ CKB ▸ CNTRL ▸ CORO2A ▸ CPOX ▸ CPSF1 ▸ CREB1 ▸
CREB3 ▸ CREB5 ▸ CRK ▸ CRKL ▸ CSE ▸ CSF1 ▸ CSF1R ▸
CSF2 ▸ CSF2RA ▸ CSF2RB ▸ CTGF ▸ CTLA4 ▸ CTNNA1 ▸ CTNNB1 ▸
CUX1 ▸ CX3CL1 ▸ CXCL10 ▸ CXCL11 ▸ CXCL12 ▸ CXCL9 ▸ CXCR4 ▸
CYP19A1 ▸ DAB1 ▸ DAB2IP ▸ DDIT3 ▸ DDX17 ▸ DDX3X ▸ DDX3Y ▸
DDX5 ▸ DGKZ ▸ DHX15 ▸ DHX30 ▸ DHX9 ▸ DLG1 ▸ DNAJA1 ▸
DNAJB11 ▸ DNAJB6 ▸ DNM1L ▸ E2F1 ▸ ECM1 ▸ ECM2 ▸ EDG1 ▸
EEF1A1 ▸ EEF1A1P5 ▸ EEF1A2 ▸ EEF2 ▸ EFNA1 ▸ EFNB2 ▸ EGF ▸
EGFR ▸ EGR1 ▸ EHMT1 ▸ EIF2AK1 ▸ EIF4EBP1 ▸ EIF5A ▸ EIF5A2 ▸
EIF5AL1 ▸ ELAVL1 ▸ ENO1 ▸ ENY2 ▸ EPB41L1 ▸ EPHB1 ▸ EPHB4 ▸
EPO ▸ EPS8 ▸ ERBB2 ▸ ERBB4 ▸ ERH ▸ ESR1 ▸ ESR2 ▸
F11R ▸ F2RL1 ▸ FAS ▸ FASLG ▸ FBL ▸ FCER1A ▸ FCER1G ▸
FCGR1A ▸ FCGR3A ▸ FCGR3B ▸ FES ▸ FGA ▸ FGB ▸ FGF1 ▸
FGF10 ▸ FGF11 ▸ FGF12 ▸ FGF13 ▸ FGF14 ▸ FGF16 ▸ FGF17 ▸
FGF18 ▸ FGF19 ▸ FGF2 ▸ FGF20 ▸ FGF21 ▸ FGF22 ▸ FGF23 ▸
FGF3 ▸ FGF4 ▸ FGF5 ▸ FGF6 ▸ FGF7 ▸ FGF8 ▸ FGF9 ▸
FGFR1OP ▸ FGFR1OP2 ▸ FGFR2 ▸ FGG ▸ FGR ▸ FIGF ▸ FLNB ▸
FLT1 ▸ FLT3 ▸ FOS ▸ FOSL1 ▸ FOXO1 ▸ FOXO3 ▸ FOXO4 ▸
FOXO6 ▸ FOXP3 ▸ FRS2 ▸ FTL ▸ FUS ▸ FYN ▸ GAB1 ▸
GAB2 ▸ GABRB1 ▸ GAPDH ▸ GDF15 ▸ GDNF ▸ GFRA1 ▸ GH1 ▸
GHR ▸ GJA1 ▸ GNA11 ▸ GNA14 ▸ GNA15 ▸ GNAI1 ▸ GNAI2 ▸
GNAI3 ▸ GNAO1 ▸ GNAQ ▸ GNB1 ▸ GNB2 ▸ GNB3 ▸ GNB4 ▸
GNB5 ▸ GNE ▸ GNG10 ▸ GNG11 ▸ GNG12 ▸ GNG13 ▸ GNG2 ▸
GNG3 ▸ GNG4 ▸ GNG5 ▸ GNG7 ▸ GNG8 ▸ GNGT1 ▸ GNGT2 ▸
GPER1 ▸ GPR1 ▸ GPR101 ▸ GPR107 ▸ GPR108 ▸ GPR110 ▸ GPR111 ▸
GPR112 ▸ GPR113 ▸ GPR114 ▸ GPR115 ▸ GPR116 ▸ GPR119 ▸ GPR12 ▸
GPR123 ▸ GPR124 ▸ GPR125 ▸ GPR126 ▸ GPR128 ▸ GPR132 ▸ GPR133 ▸
GPR135 ▸ GPR137 ▸ GPR139 ▸ GPR141 ▸ GPR142 ▸ GPR143 ▸ GPR144 ▸
GPR146 ▸ GPR148 ▸ GPR149 ▸ GPR15 ▸ GPR150 ▸ GPR151 ▸ GPR152 ▸
GPR153 ▸ GPR155 ▸ GPR156 ▸ GPR157 ▸ GPR158 ▸ GPR160 ▸ GPR161 ▸
GPR162 ▸ GPR17 ▸ GPR171 ▸ GPR173 ▸ GPR174 ▸ GPR176 ▸ GPR179 ▸
GPR18 ▸ GPR180 ▸ GPR182 ▸ GPR183 ▸ GPR19 ▸ GPR20 ▸ GPR21 ▸
GPR22 ▸ GPR25 ▸ GPR26 ▸ GPR27 ▸ GPR3 ▸ GPR31 ▸ GPR32 ▸
GPR33 ▸ GPR34 ▸ GPR35 ▸ GPR36 ▸ GPR37 ▸ GPR39 ▸ GPR4 ▸
GPR42 ▸ GPR45 ▸ GPR50 ▸ GPR52 ▸ GPR55 ▸ GPR56 ▸ GPR6 ▸
GPR61 ▸ GPR62 ▸ GPR63 ▸ GPR64 ▸ GPR65 ▸ GPR68 ▸ GPR75 ▸
GPR78 ▸ GPR79 ▸ GPR82 ▸ GPR83 ▸ GPR84 ▸ GPR85 ▸ GPR87 ▸
GPR88 ▸ GPR97 ▸ GPR98 ▸ GPS2 ▸ GRAP2 ▸ GRB2 ▸ GRIN2B ▸
GRP ▸ GSK3A ▸ GSK3B ▸ GSN ▸ GTPBP1 ▸ GYS1 ▸ GYS2 ▸
H2AFJ ▸ H2BFS ▸ HBEGF ▸ HCST ▸ HDAC1 ▸ HDAC2 ▸ HDAC3 ▸
HGF ▸ HIF1A ▸ HIST1H1A ▸ HIST1H1T ▸ HIST1H2AB ▸ HIST1H2AC ▸ HIST1H2AD ▸
HIST1H2AE ▸ HIST1H2AG ▸ HIST1H2AH ▸ HIST1H2AJ ▸ HIST1H2BB ▸ HIST1H2BD ▸ HIST1H2BH ▸
HIST1H2BJ ▸ HIST1H2BK ▸ HIST1H2BL ▸ HIST1H2BM ▸ HIST1H2BN ▸ HIST1H2BO ▸ HIST1H4A ▸
HIST2H2AA3 ▸ HIST2H2AA4 ▸ HIST2H2AC ▸ HIST2H2BE ▸ HIST2H2BF ▸ HIST3H2A ▸ HIST3H2BB ▸
HLA-A ▸ HLA-B ▸ HLA-DRA ▸ HLA-DRB1 ▸ HLA-E ▸ HMGB1 ▸ HMOX1 ▸
HNRNPA0 ▸ HNRNPA1 ▸ HNRNPA2B1 ▸ HNRNPA3 ▸ HNRNPAB ▸ HNRNPC ▸ HNRNPD ▸
HNRNPDL ▸ HNRNPF ▸ HNRNPH1 ▸ HNRNPH2 ▸ HNRNPH3 ▸ HNRNPK ▸ HNRNPL ▸
HNRNPR ▸ HNRNPU ▸ HNRNPUL1 ▸ HRAS ▸ HRG ▸ HRNR ▸ HSP90AA1 ▸
HSP90AB1 ▸ HSPB1 ▸ HSPG2 ▸ ICAM1 ▸ ICOS ▸ IFI27 ▸ IFNB1 ▸
IFNG ▸ IFNGR1 ▸ IGF1R ▸ IGF2 ▸ IGF2BP1 ▸ IGF2BP2 ▸ IGF2BP3 ▸
IGFBP3 ▸ IGHE ▸ IGHG1 ▸ IGHG2 ▸ IGHG3 ▸ IGHG4 ▸ IGKC ▸
IGKV1-5 ▸ IGKV4-1 ▸ IGLC1 ▸ IGLC2 ▸ IGLC3 ▸ IGLC6 ▸ IGLC7 ▸
IKBKB ▸ IKBKG ▸ IL10 ▸ IL11 ▸ IL12A ▸ IL12B ▸ IL12RB1 ▸
IL13 ▸ IL15 ▸ IL16 ▸ IL17A ▸ IL18 ▸ IL19 ▸ IL1A ▸
IL1B ▸ IL1R1 ▸ IL1RAP ▸ IL1RN ▸ IL2 ▸ IL20 ▸ IL21 ▸
IL22 ▸ IL23A ▸ IL23R ▸ IL24 ▸ IL25 ▸ IL26 ▸ IL27 ▸
IL2RB ▸ IL2RG ▸ IL3 ▸ IL31 ▸ IL32 ▸ IL33 ▸ IL34 ▸
IL37 ▸ IL3RA ▸ IL4 ▸ IL4R ▸ IL5 ▸ IL5RA ▸ IL6 ▸
IL6ST ▸ IL7 ▸ IL8 ▸ IL9 ▸ ILF2 ▸ ILF3 ▸ ILK ▸
INPP5B ▸ INPP5E ▸ INS-IGF2 ▸ INSR ▸ INSRR ▸ IRF1 ▸ IRF6 ▸
IRS1 ▸ IRS2 ▸ IRS4 ▸ ITGA5 ▸ ITGA6 ▸ ITGAV ▸ ITGB1 ▸
ITGB2 ▸ ITGB3 ▸ ITGB4 ▸ ITIH1 ▸ ITIH4 ▸ ITK ▸ Il7r ▸
JAK1 ▸ JAK2 ▸ JAK3 ▸ JUN ▸ JUP ▸ KHDRBS1 ▸ KIRREL ▸
KIT ▸ KITLG ▸ KL ▸ KLB ▸ KLRC2 ▸ KLRD1 ▸ KLRK1 ▸
KRAS ▸ LAT ▸ LAT2 ▸ LCK ▸ LDHB ▸ LDLR ▸ LEP ▸
LGALS3 ▸ LGALS3BP ▸ LIF ▸ LPA ▸ LRPPRC ▸ LTB ▸ LYN ▸
MAP2K1 ▸ MAP2K2 ▸ MAP3K5 ▸ MAP3K7 ▸ MARCKS ▸ MASP1 ▸ MATR3 ▸
MCL1 ▸ MDH2 ▸ MDM2 ▸ MET ▸ MIF ▸ MLST8 ▸ MMP1 ▸
MMP10 ▸ MMP11 ▸ MMP12 ▸ MMP13 ▸ MMP14 ▸ MMP15 ▸ MMP16 ▸
MMP17 ▸ MMP19 ▸ MMP2 ▸ MMP20 ▸ MMP21 ▸ MMP24 ▸ MMP25 ▸
MMP26 ▸ MMP27 ▸ MMP28 ▸ MMP3 ▸ MMP7 ▸ MMP8 ▸ MMP9 ▸
MOK ▸ MOV10 ▸ MRAS ▸ MRE11A ▸ MRPL12 ▸ MRPS14 ▸ MRPS17 ▸
MRPS18B ▸ MRPS22 ▸ MRPS23 ▸ MRPS25 ▸ MRPS26 ▸ MRPS27 ▸ MRPS28 ▸
MRPS34 ▸ MS4A2 ▸ MSC ▸ MT3 ▸ MUC1 ▸ MUC8 ▸ MYC ▸
MYCN ▸ MYD88 ▸ MYH10 ▸ MYH14 ▸ MYH9 ▸ MYL6 ▸ MYLIP ▸
MYO1C ▸ MYOG ▸ NA ▸ NANOG ▸ NBPF8 ▸ NCF1 ▸ NCF4 ▸
NCOR1 ▸ NEDD9 ▸ NEFH ▸ NFAT5 ▸ NFE2L2 ▸ NFKBIA ▸ NGF ▸
NGFB ▸ NKRF ▸ NM ▸ NOS1 ▸ NOS2 ▸ NOS3 ▸ NOTCH1 ▸
NOX1 ▸ NOX3 ▸ NOX4 ▸ NOX5 ▸ NPHS1 ▸ NPHS2 ▸ NPM1 ▸
NPY4R ▸ NR3C1 ▸ NRAS ▸ NRG1 ▸ NTF3 ▸ NTRK1 ▸ NTRK2 ▸
NTRK3 ▸ OCRL ▸ ODC1 ▸ PABPC1 ▸ PABPC4 ▸ PABPN1 ▸ PAICS ▸
PAK1 ▸ PAK2 ▸ PAK3 ▸ PAK4 ▸ PAK6 ▸ PAK7 ▸ PARP1 ▸
PBK ▸ PCBP1 ▸ PCBP2 ▸ PCBP3 ▸ PCID2 ▸ PCNA ▸ PDE3B ▸
PDE4D ▸ PDGFB ▸ PDGFRA ▸ PDGFRB ▸ PDK1 ▸ PDLIM7 ▸ PDPK1 ▸
PDX1 ▸ PGAM1 ▸ PGAM2 ▸ PGAM4 ▸ PGF ▸ PGK1 ▸ PGP ▸
PGR ▸ PHKA2 ▸ PHLDA1 ▸ PI3 ▸ PIK3AP1 ▸ PIK3C2A ▸ PIK3C2B ▸
PIK3C2G ▸ PIK3CB ▸ PIK3CD ▸ PIK3CG ▸ PIK3IP1 ▸ PIK3R1 ▸ PIK3R2 ▸
PIK3R3 ▸ PIK3R4 ▸ PIK3R5 ▸ PIK3R6 ▸ PIP ▸ PIP4K2A ▸ PIP4K2C ▸
PIP5K1A ▸ PIP5K1B ▸ PIP5K1C ▸ PKD1 ▸ PKD2 ▸ PKD3 ▸ PLA2G1B ▸
PLA2G4A ▸ PLAT ▸ PLAU ▸ PLCB1 ▸ PLCB2 ▸ PLCB3 ▸ PLCB4 ▸
PLCD1 ▸ PLCD3 ▸ PLCD4 ▸ PLCE1 ▸ PLCG1 ▸ PLCG2 ▸ PLCZ1 ▸
PLD1 ▸ PLD2 ▸ PLD3 ▸ PLD4 ▸ PLD5 ▸ PLD6 ▸ PLEK ▸
PON2 ▸ POT1 ▸ POTEKP ▸ PPARG ▸ PPIA ▸ PPP1CA ▸ PPP1CB ▸
PPP1CC ▸ PPP1R3A ▸ PRDX2 ▸ PRDX6 ▸ PREX1 ▸ PRKAA1 ▸ PRKAA2 ▸
PRKAB1 ▸ PRKAB2 ▸ PRKACB ▸ PRKACG ▸ PRKAG1 ▸ PRKAG2 ▸ PRKAR1A ▸
PRKAR1B ▸ PRKAR2A ▸ PRKAR2B ▸ PRKCA ▸ PRKCI ▸ PRKCZ ▸ PRKRA ▸
PRL ▸ PSEN1 ▸ PTBP1 ▸ PTCD3 ▸ PTGES ▸ PTGS2 ▸ PTH ▸
PTK2 ▸ PTK6 ▸ PTK7 ▸ PTMA ▸ PTPN1 ▸ PTPN11 ▸ PTTG1 ▸
RAB5A ▸ RAC1 ▸ RAC2 ▸ RAC3 ▸ RAD50 ▸ RAE1 ▸ RAF1 ▸
RALY ▸ RASD2 ▸ RASGRP3 ▸ RBBP4 ▸ RBBP7 ▸ RBL2 ▸ RBMX ▸
RHEB ▸ RHOA ▸ RHOG ▸ RICTOR ▸ RLN1 ▸ RLN2 ▸ RLN3 ▸
RNF19A ▸ RPL17 ▸ RPL22 ▸ RPL23 ▸ RPL28 ▸ RPLP0 ▸ RPLP0P6 ▸
RPLP1 ▸ RPS10 ▸ RPS11 ▸ RPS12 ▸ RPS18 ▸ RPS2 ▸ RPS20 ▸
RPS24 ▸ RPS3 ▸ RPS4X ▸ RPS5 ▸ RPS6KB1 ▸ RPSA ▸ RPTOR ▸
RRAS2 ▸ RTCB ▸ RUNX2 ▸ RUVBL1 ▸ RUVBL2 ▸ S100A10 ▸ SEMG1 ▸
SEMG2 ▸ SERPINE1 ▸ SETD2 ▸ SGK1 ▸ SGK2 ▸ SGK3 ▸ SH2D2A ▸
SH3KBP1 ▸ SHANK3 ▸ SHC1 ▸ SHC2 ▸ SHC3 ▸ SIRT1 ▸ SKP2 ▸
SLC22A3 ▸ SLC25A16 ▸ SLC25A3 ▸ SLC25A31 ▸ SLC25A4 ▸ SLC25A5 ▸ SLC2A1 ▸
SLC2A4 ▸ SLC9A1 ▸ SLC9A3R1 ▸ SLPI ▸ SMAD1 ▸ SMAD2 ▸ SMAD3 ▸
SMAD4 ▸ SMAD5 ▸ SMAD6 ▸ SMAD7 ▸ SMAD9 ▸ SMN1 ▸ SMO ▸
SNAI2 ▸ SNRPD3 ▸ SNRPF ▸ SOAT1 ▸ SOCS3 ▸ SOS1 ▸ SP1 ▸
SPP1 ▸ SPTA1 ▸ SQSTM1 ▸ SRC ▸ SREBF1 ▸ SSR1 ▸ SST ▸
STAT1 ▸ STAT3 ▸ STAT5B ▸ STAT6 ▸ STAU1 ▸ STK10 ▸ STK11 ▸
STK16 ▸ STK19 ▸ STK24 ▸ STK25 ▸ STK3 ▸ STK31 ▸ STK33 ▸
STK35 ▸ STK36 ▸ STK38 ▸ STK39 ▸ STK4 ▸ STK40 ▸ SYK ▸
SYNCRIP ▸ SYNJ1 ▸ SYNJ2 ▸ SYT1 ▸ TAT ▸ TBL1X ▸ TBL1XR1 ▸
TCF12 ▸ TCF15 ▸ TCF19 ▸ TCF20 ▸ TCF21 ▸ TCF23 ▸ TCF24 ▸
TCF25 ▸ TCF3 ▸ TCF4 ▸ TCF7 ▸ TEK ▸ TERF1 ▸ TERF2 ▸
TERF2IP ▸ TFRC ▸ TGFB1 ▸ TGFB2 ▸ TGFB3 ▸ TIAM2 ▸ TIMM50 ▸
TINF2 ▸ TLR1 ▸ TLR10 ▸ TLR2 ▸ TLR3 ▸ TLR4 ▸ TLR5 ▸
TLR6 ▸ TLR7 ▸ TLR8 ▸ TLR9 ▸ TMED7 ▸ TNF ▸ TNFSF10 ▸
TNFSF13B ▸ TP53 ▸ TPI1 ▸ TPO ▸ TRA@ ▸ TRAT1 ▸ TRB@ ▸
TREM2 ▸ TRIM21 ▸ TRIM24 ▸ TRNAE1 ▸ TSC2 ▸ TUBA1A ▸ TUBA1C ▸
TUBA4A ▸ TUBB ▸ TUBB4B ▸ TXK ▸ TYR ▸ TYROBP ▸ UBC ▸
UBTF ▸ UCN ▸ UFD1L ▸ UNC5B ▸ UPF1 ▸ UVRAG ▸ VARS2 ▸
VAV1 ▸ VAV2 ▸ VAV3 ▸ VCAM1 ▸ VEGF ▸ VEGFC ▸ VLDLR ▸
WDR5 ▸ WDR6 ▸ WNK1 ▸ WNT1 ▸ WNT11 ▸ WNT16 ▸ WNT2 ▸
WNT3 ▸ WNT4 ▸ WNT6 ▸ XIAP ▸ XRCC5 ▸ XRCC6 ▸ XRN2 ▸
YBX3 ▸ YES1 ▸ YWHAE ▸ YWHAG ▸ YWHAH ▸ YWHAQ ▸ YWHAZ ▸
ZAP70 ▸ ZGLP1 ▸ ZMYM2 ▸
Data information
Please see the Gene Interactions Track Manual.