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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Immunity 2000, PMID: 10933394

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.

Fujimoto, M; Fujimoto, Y; Poe, J C; Jansen, P J; Lowell, C A; DeFranco, A L; Tedder, T F

CD19 regulates constitutive and antigen receptor-induced signaling thresholds in B lymphocytes through its unique cytoplasmic domain. Herein, we demonstrate a novel molecular mechanism where interactions between CD19 and Lyn amplify basal and antigen receptor-induced Src family kinase activation. Lyn expression was required for CD19 tyrosine phosphorylation in primary B cells. Experiments with purified proteins demonstrated that CD19-Y513 was Lyn's initial phosphorylation and binding site. This led to processive phosphorylation of CD19-Y482, which recruited a second Lyn molecule, allowing for transphosphorylation and amplification of Lyn activation. In vivo, CD19 deficiency impaired, and CD19 overexpression enhanced, Lyn kinase activity. Thus, CD19 functions as a specialized adapter protein for the amplification of Src family kinases that is crucial for intrinsic and antigen receptor-induced signal transduction.

Document information provided by NCBI PubMed

Text Mining Data

Src → CD19: " CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification "

protein tyrosine kinase → CD19: " CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification "

CD19 → Lyn: " Lyn expression was required for CD19 tyrosine phosphorylation in primary B cells "

Lyn ⊣ CD19: " In vivo, CD19 deficiency impaired, and CD19 overexpression enhanced , Lyn kinase activity "

Manually curated Databases

  • IRef Hprd Interaction: LYN — CD19 (in vitro)
  • IRef Hprd Interaction: LYN — CD19 (in vivo)
  • Reactome Reaction: CD79B → NCK1 (indirect_complex)
  • Reactome Reaction: SYK → SHC1 (indirect_complex)
  • Reactome Reaction: IGHM → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → CBLB (indirect_complex)
  • Reactome Reaction: CD79B → DAPP1 (indirect_complex)
  • Reactome Reaction: PLCG2 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: PIK3CD → PIK3AP1 (indirect_complex)
  • Reactome Reaction: BTK → IGHM (indirect_complex)
  • Reactome Reaction: IGKV4-1 → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG1 → BLNK (indirect_complex)
  • Reactome Reaction: IGKV1-5 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGHM → PLCG1 (indirect_complex)
  • Reactome Reaction: BTK → IGKV1-5 (indirect_complex)
  • Reactome Reaction: PIK3CD → VAV1 (indirect_complex)
  • Reactome Reaction: PIK3R1 → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG2 → BLNK (indirect_complex)
  • Reactome Reaction: SOS1 → VAV1 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC3 (indirect_complex)
  • Reactome Reaction: SYK → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → SHC1 (direct_complex)
  • Reactome Reaction: GRB2 → DAPP1 (indirect_complex)
  • Reactome Reaction: SYK → NCK1 (indirect_complex)
  • Reactome Reaction: BTK → SYK (indirect_complex)
  • Reactome Reaction: CD79A → SHC1 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC6 (indirect_complex)
  • Reactome Reaction: NCK1 → PLCG2 (indirect_complex)
  • Reactome Reaction: PIK3R1 → PIK3AP1 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC6 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC7 (indirect_complex)
  • Reactome Reaction: BTK → IGKV4-1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → PLCG2 (indirect_complex)
  • Reactome Reaction: CD79A → PLCG2 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC3 (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC1 (indirect_complex)
  • Reactome Reaction: IGHD → VAV1 (indirect_complex)
  • Reactome Reaction: DAPP1 → SHC1 (indirect_complex)
  • Reactome Reaction: SYK → VAV1 (indirect_complex)
  • Reactome Reaction: SHC1 → BLNK (indirect_complex)
  • Reactome Reaction: CD79B → VAV1 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC3 (indirect_complex)
  • Reactome Reaction: BTK → IGLC1 (indirect_complex)
  • Reactome Reaction: IGKC → PLCG1 (indirect_complex)
  • Reactome Reaction: PLCG2 → SHC1 (indirect_complex)
  • Reactome Reaction: BTK → IGKC (indirect_complex)
  • Reactome Reaction: BTK → NCK1 (indirect_complex)
  • Reactome Reaction: NCK1 → PLCG1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC7 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC6 (indirect_complex)
  • Reactome Reaction: PLCG1 → VAV1 (indirect_complex)
  • Reactome Reaction: SHC1 → CBLB (indirect_complex)
  • Reactome Reaction: VAV1 → BLNK (indirect_complex)
  • Reactome Reaction: GRB2 → VAV1 (indirect_complex)
  • Reactome Reaction: CBL → PLCG2 (indirect_complex)
  • Reactome Reaction: PLCG1 → DAPP1 (indirect_complex)
  • Reactome Reaction: BTK → SHC1 (indirect_complex)
  • Reactome Reaction: GRB2 → PIK3R1 (indirect_complex)
  • Reactome Reaction: GRB2 → SHC1 (indirect_complex)
  • Reactome Reaction: IGKC → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → SOS1 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC2 (indirect_complex)
  • Reactome Reaction: BTK → CBL (indirect_complex)
  • Reactome Reaction: GRB2 → NCK1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → NCK1 (indirect_complex)
  • Reactome Reaction: PLCG1 → SOS1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC2 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC2 (indirect_complex)
  • Reactome Reaction: NCK1 → VAV1 (direct_complex)
  • Reactome Reaction: PLCG2 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGHD → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC7 (indirect_complex)
  • Reactome Reaction: BTK → CD79B (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC1 (indirect_complex)
  • Reactome Reaction: PLCG1 → CBLB (indirect_complex)
  • Reactome Reaction: BTK → PLCG1 (indirect_complex)
  • Reactome Reaction: BTK → BLNK (indirect_complex)
  • Reactome Reaction: PLCG2 → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG2 → SOS1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → PLCG1 (indirect_complex)
  • Reactome Reaction: IGHM → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC6 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC7 (indirect_complex)
  • Reactome Reaction: IGHM → NCK1 (indirect_complex)
  • Reactome Reaction: CD79A → DAPP1 (indirect_complex)
  • Reactome Reaction: GRB2 → PIK3CD (indirect_complex)
  • Reactome Reaction: IGHD → NCK1 (indirect_complex)
  • Reactome Reaction: DAPP1 → BLNK (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC7 (indirect_complex)
  • Reactome Reaction: BTK → PLCG2 (indirect_complex)
  • Reactome Reaction: DAPP1 → CBLB (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC2 (indirect_complex)
  • Reactome Reaction: BTK → CD79A (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC2 (indirect_complex)
  • Reactome Reaction: IGHD → SHC1 (indirect_complex)
  • Reactome Reaction: IGKC → SHC1 (indirect_complex)
  • Reactome Reaction: SOS1 → DAPP1 (indirect_complex)
  • Reactome Reaction: VAV1 → CBLB (indirect_complex)
  • Reactome Reaction: CD19 → PIK3R1 (indirect_complex)
  • Reactome Reaction: CD19 → PIK3CD (indirect_complex)
  • Reactome Reaction: GRB2 → VAV1 (direct_complex)
  • Reactome Reaction: PLCG2 → IGLC7 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC1 (indirect_complex)
  • Reactome Reaction: IGHD → PLCG1 (indirect_complex)
  • Reactome Reaction: PLCG2 → CBLB (indirect_complex)
  • Reactome Reaction: IGKC → PLCG2 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → NCK1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → PLCG1 (indirect_complex)
  • Reactome Reaction: CD19 → GRB2 (direct_complex)
  • Reactome Reaction: CBL → DAPP1 (indirect_complex)
  • Reactome Reaction: SYK → PLCG1 (indirect_complex)
  • Reactome Reaction: CD79A → PLCG1 (indirect_complex)
  • Reactome Reaction: CD79A → VAV1 (indirect_complex)
  • Reactome Reaction: NCK1 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: PLCG1 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC7 (indirect_complex)
  • Reactome Reaction: SYK → PLCG2 (indirect_complex)
  • Reactome Reaction: BTK → VAV1 (indirect_complex)
  • Reactome Reaction: SOS1 → SHC1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → VAV1 (indirect_complex)
  • Reactome Reaction: BTK → CBLB (indirect_complex)
  • Reactome Reaction: BTK → GRB2 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC6 (indirect_complex)
  • Reactome Reaction: CBL → VAV1 (indirect_complex)
  • Reactome Reaction: IGHD → PLCG2 (indirect_complex)
  • Reactome Reaction: NCK1 → BLNK (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC1 (indirect_complex)
  • Reactome Reaction: CBL → NCK1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC3 (indirect_complex)
  • Reactome Reaction: VAV1 → SHC1 (direct_complex)
  • Reactome Reaction: IGHM → PLCG2 (indirect_complex)
  • Reactome Reaction: CBL → SHC1 (indirect_complex)
  • Reactome Reaction: SH3KBP1 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGKC → VAV1 (indirect_complex)
  • Reactome Reaction: CD79A → NCK1 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC2 (indirect_complex)
  • Reactome Reaction: NCK1 → DAPP1 (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC3 (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC6 (indirect_complex)
  • Reactome Reaction: BTK → SH3KBP1 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC6 (indirect_complex)
  • Reactome Reaction: IGKC → NCK1 (indirect_complex)
  • Reactome Reaction: CD79B → PLCG1 (indirect_complex)
  • Reactome Reaction: VAV1 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → SHC1 (indirect_complex)
  • Reactome Reaction: BTK → SOS1 (indirect_complex)
  • Reactome Reaction: CBL → PLCG1 (indirect_complex)
  • Reactome Reaction: CD19 → VAV1 (direct_complex)
  • Reactome Reaction: NCK1 → IGLC3 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC3 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC2 (indirect_complex)
  • Reactome Reaction: BTK → DAPP1 (indirect_complex)
  • Reactome Reaction: CD79B → PLCG2 (indirect_complex)
  • Reactome Reaction: PLCG1 → SHC1 (indirect_complex)
  • Reactome Reaction: IGHM → SHC1 (indirect_complex)
  • Reactome Reaction: VAV1 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → SHC1 (indirect_complex)
  • Reactome Reaction: BTK → IGHD (indirect_complex)
  • Reactome Reaction: CD79B → SHC1 (indirect_complex)
  • Reactome Reaction: GRB2 → PLCG1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → PLCG2 (indirect_complex)
  • Reactome Reaction: GRB2 → PLCG2 (indirect_complex)
  • Reactome Reaction: SH3KBP1 → SHC1 (indirect_complex)
In total, 164 gene pairs are associated to this article in curated databases