Gene interactions and pathways from curated databases and text-mining
Development 2000, PMID: 10851137

The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation.

Bae, S; Bessho, Y; Hojo, M; Kageyama, R

We have isolated the basic helix-loop-helix (bHLH) gene Hes6, a novel member of the family of mammalian homologues of Drosophila hairy and Enhancer of split. Hes6 is expressed by both undifferentiated and differentiated cells, unlike Hes1, which is expressed only by the former cells. Hes6 alone does not bind to the DNA but suppresses Hes1 from repressing transcription. In addition, Hes6 suppresses Hes1 from inhibiting Mash1-E47 heterodimer and thereby enables Mash1 and E47 to upregulate transcription in the presence of Hes1. Furthermore, misexpression of Hes6 with retrovirus in the developing retina promotes rod photoreceptor differentiation, like Mash1, in sharp contrast to Hes1, which inhibits cell differentiation. These results suggest that Hes6 is an inhibitor of Hes1, supports Mash1 activity and promotes cell differentiation. Mutation analysis revealed that Hes1- and Hes6-specific functions are, at least in part, interchangeable by alteration of the loop region, suggesting that the loop is not simply a nonfunctional spacer but plays an important role in the specific functions.

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Text Mining Data

Hes1 ⊣ Hes6: " The bHLH gene Hes6 , an inhibitor of Hes1 , promotes neuronal differentiation "

neuronal differentiation → Hes6: " The bHLH gene Hes6 , an inhibitor of Hes1, promotes neuronal differentiation "

Hes1 ⊣ Hes6: " Hes6 alone does not bind to the DNA but suppresses Hes1 from repressing transcription "

Manually curated Databases

  • Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3)
  • IRef Hprd Interaction: HES6 — HES1 (in vivo)
  • IRef Hprd Interaction: HES6 — HES1 (in vitro)
  • NCI Pathway Database Notch-mediated HES/HEY network: HES1/TLE1/PARP1 complex (HES1-TLE1-PARP1) → MASH1 (ASCL1) (transcription, inhibits)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database Notch-mediated HES/HEY network: HES1/TLE1/PARP1 complex (HES1-TLE1-PARP1) → HES1/HES6 complex (HES1-HES6) (transcription, inhibits)
    Evidence: mutant phenotype, assay, physical interaction
  • NCI Pathway Database Notch-mediated HES/HEY network: HES6 (HES6) → HES1 (HES1) (modification, collaborate)
    Evidence: physical interaction
  • NCI Pathway Database Notch-mediated HES/HEY network: HES6 (HES6) → HES1/HES6 complex (HES1-HES6) (modification, collaborate)
    Evidence: physical interaction
  • NCI Pathway Database Notch-mediated HES/HEY network: HES1 (HES1) → HES1/HES6 complex (HES1-HES6) (modification, collaborate)
    Evidence: physical interaction
In total, 8012 gene pairs are associated to this article in curated databases