ID:ZMYM2_HUMAN DESCRIPTION: RecName: Full=Zinc finger MYM-type protein 2; AltName: Full=Fused in myeloproliferative disorders protein; AltName: Full=Rearranged in atypical myeloproliferative disorder protein; AltName: Full=Zinc finger protein 198; FUNCTION: May function as a transcription factor. SUBUNIT: May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. SUBCELLULAR LOCATION: Nucleus (Potential). DISEASE: Note=A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. SIMILARITY: Contains 9 MYM-type zinc fingers. SEQUENCE CAUTION: Sequence=AAB88464.1; Type=Frameshift; Positions=330, 966, 1009, 1017; Sequence=AAC23591.1; Type=Frameshift; Positions=330; Sequence=CAA73875.1; Type=Frameshift; Positions=388, 403, 406, 409, 418; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ZNF198ID114.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBW7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0004713 protein tyrosine kinase activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0031624 ubiquitin conjugating enzyme binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007010 cytoskeleton organization GO:0007275 multicellular organism development GO:0008150 biological_process GO:0018108 peptidyl-tyrosine phosphorylation GO:0022604 regulation of cell morphogenesis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
