Human Gene ZHX2 (ENST00000314393.6_4) from GENCODE V47lift37
Description: Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). (from UniProt Q9Y6X8) Gencode Transcript: ENST00000314393.6_4 Gencode Gene: ENSG00000178764.8_8 Transcript (Including UTRs) Position: hg19 chr8:123,793,894-123,986,750 Size: 192,857 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr8:123,963,751-123,966,264 Size: 2,514 Coding Exon Count: 1
ID:ZHX2_HUMAN DESCRIPTION: RecName: Full=Zinc fingers and homeoboxes protein 2; AltName: Full=Alpha-fetoprotein regulator 1; Short=AFP regulator 1; AltName: Full=Regulator of AFP; AltName: Full=Zinc finger and homeodomain protein 2; FUNCTION: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. SUBUNIT: Forms homodimer (via homeobox domain). Forms heterodimer with ZHX1 (via HD1 domain). Forms heterodimer with ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N- terminus). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in podocytes. SIMILARITY: Belongs to the ZHX family. SIMILARITY: Contains 2 C2H2-type zinc fingers. SIMILARITY: Contains 4 homeobox DNA-binding domains. SEQUENCE CAUTION: Sequence=BAA74877.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6X8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006402 mRNA catabolic process GO:0035019 somatic stem cell population maintenance GO:0045665 negative regulation of neuron differentiation GO:0045892 negative regulation of transcription, DNA-templated
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
