ID:1433T_HUMAN DESCRIPTION: RecName: Full=14-3-3 protein theta; AltName: Full=14-3-3 protein T-cell; AltName: Full=14-3-3 protein tau; AltName: Full=Protein HS1; FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. SUBUNIT: Homodimer. Interacts with CDK16 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1. INTERACTION: Q9P0K1-3:ADAM22; NbExp=2; IntAct=EBI-359854, EBI-1567267; P49407:ARRB1; NbExp=3; IntAct=EBI-359854, EBI-743313; P32121:ARRB2; NbExp=3; IntAct=EBI-359854, EBI-714559; O94921:CDK14; NbExp=3; IntAct=EBI-359854, EBI-1043945; P00533:EGFR; NbExp=4; IntAct=EBI-359854, EBI-297353; P23945:FSHR; NbExp=3; IntAct=EBI-359854, EBI-848239; Q14678:KANK1; NbExp=2; IntAct=EBI-359854, EBI-2556221; Q14678-2:KANK1; NbExp=3; IntAct=EBI-359854, EBI-6173812; SUBCELLULAR LOCATION: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals. TISSUE SPECIFICITY: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. PTM: Ser-232 is probably phosphorylated by CK1. SIMILARITY: Belongs to the 14-3-3 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P27348
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0019904 protein domain specific binding GO:0042802 identical protein binding GO:0047485 protein N-terminus binding
Biological Process: GO:0021762 substantia nigra development GO:0045892 negative regulation of transcription, DNA-templated GO:0061024 membrane organization GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
