ID:FL2D_HUMAN DESCRIPTION: RecName: Full=Pre-mRNA-splicing regulator WTAP; AltName: Full=Female-lethal(2)D homolog; Short=hFL(2)D; AltName: Full=WT1-associated protein; AltName: Full=Wilms tumor 1-associating protein; FUNCTION: Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation. SUBUNIT: Interacts with WT1. SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Ubiquitously expressed. INDUCTION: In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the fl(2)d family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15007
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
