ID:WNT1_HUMAN DESCRIPTION: RecName: Full=Proto-oncogene Wnt-1; AltName: Full=Proto-oncogene Int-1 homolog; Flags: Precursor; FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. SUBUNIT: Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. PTM: Palmitoylation at Ser-224 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-93. Palmitoylation is necessary for proper trafficking to cell surface. SIMILARITY: Belongs to the Wnt family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04628
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF213374 - JP 2014500723-A/20877: Polycomb-Associated Non-Coding RNAs. LF212638 - JP 2014500723-A/20141: Polycomb-Associated Non-Coding RNAs. FW415541 - NUCLEIC ACID COMPOUNDS FOR INHIBITING WNT GENE EXPRESSION AND USES THEREOF. JA824049 - Sequence 1158 from Patent EP2471920. JD128746 - Sequence 109770 from Patent EP1572962. BC074798 - Homo sapiens wingless-type MMTV integration site family, member 1, mRNA (cDNA clone MGC:104071 IMAGE:30915522), complete cds. BC074799 - Homo sapiens wingless-type MMTV integration site family, member 1, mRNA (cDNA clone MGC:103919 IMAGE:30915309), complete cds. JD535262 - Sequence 516286 from Patent EP1572962. JD360913 - Sequence 341937 from Patent EP1572962. JD209726 - Sequence 190750 from Patent EP1572962. KJ892383 - Synthetic construct Homo sapiens clone ccsbBroadEn_01777 WNT1 gene, encodes complete protein. BT019429 - Homo sapiens wingless-type MMTV integration site family, member 1 mRNA, complete cds. JD522554 - Sequence 503578 from Patent EP1572962. JD174250 - Sequence 155274 from Patent EP1572962. JD121763 - Sequence 102787 from Patent EP1572962. JD389583 - Sequence 370607 from Patent EP1572962. JD254969 - Sequence 235993 from Patent EP1572962. JD117381 - Sequence 98405 from Patent EP1572962. JD311243 - Sequence 292267 from Patent EP1572962. JD394042 - Sequence 375066 from Patent EP1572962. JD535071 - Sequence 516095 from Patent EP1572962. JD475559 - Sequence 456583 from Patent EP1572962. JD515377 - Sequence 496401 from Patent EP1572962. JD488854 - Sequence 469878 from Patent EP1572962. JD102404 - Sequence 83428 from Patent EP1572962. JD168785 - Sequence 149809 from Patent EP1572962. JD372074 - Sequence 353098 from Patent EP1572962. JD460266 - Sequence 441290 from Patent EP1572962. JD307630 - Sequence 288654 from Patent EP1572962. JD245016 - Sequence 226040 from Patent EP1572962. JD363159 - Sequence 344183 from Patent EP1572962. JD290315 - Sequence 271339 from Patent EP1572962. JD433267 - Sequence 414291 from Patent EP1572962. MA448951 - JP 2018138019-A/20877: Polycomb-Associated Non-Coding RNAs. MA448215 - JP 2018138019-A/20141: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_hesPathway - Segmentation Clock h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages h_ps1Pathway - Presenilin action in Notch and Wnt signaling h_alkPathway - ALK in cardiac myocytes h_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2 h_wntPathway - WNT Signaling Pathway
Reactome (by CSHL, EBI, and GO)
Protein P04628 (Reactome details) participates in the following event(s):
R-NUL-209104 Frog CKIgamma further phosphorylates Human LRP6 in the receptor complex R-HSA-201708 Frizzled receptors bind Wnts R-HSA-3238694 PORCN palmitoleoylates N-glycosyl WNTs R-HSA-1458875 WNT binds to FZD and LRP5/6 R-HSA-3247843 secretion of WNT ligands R-HSA-3858491 WNTs bind the FZD receptor to initiate PCP pathway R-HSA-5323545 Canonical WNT signaling through the atypical receptor RYK R-HSA-3247840 WLS binds WNT ligands in the Golgi R-HSA-1504188 FZD recruits DVL to the receptor complex R-HSA-201691 Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI R-NUL-1458902 frog CK1gamma phosphorylates LRP5/6 R-HSA-201677 Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta R-HSA-3858482 DVL is recruited to the receptor R-HSA-3858480 WNT-dependent phosphorylation of DVL R-HSA-1504186 DVL recruits GSK3beta:AXIN1 to the receptor complex R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-3238698 WNT ligand biogenesis and trafficking R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-4086400 PCP/CE pathway R-HSA-500792 GPCR ligand binding R-HSA-195721 Signaling by WNT R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-3858494 Beta-catenin independent WNT signaling R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
