Human Gene ATP5MK (ENST00000309579.7_6) from GENCODE V47lift37
  Description: ATP synthase membrane subunit k, transcript variant 1 (from RefSeq NM_001206426.2)
Gencode Transcript: ENST00000309579.7_6
Gencode Gene: ENSG00000173915.16_11
Transcript (Including UTRs)
   Position: hg19 chr10:105,148,807-105,156,223 Size: 7,417 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr10:105,151,951-105,152,214 Size: 264 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:105,148,807-105,156,223)mRNA (may differ from genome)Protein (58 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: USMG5_HUMAN
DESCRIPTION: RecName: Full=Up-regulated during skeletal muscle growth protein 5; AltName: Full=Diabetes-associated protein in insulin-sensitive tissues; AltName: Full=HCV F-transactivated protein 2;
FUNCTION: Plays a critical role in maintaining the ATP synthase population in mitochondria.
SUBUNIT: Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).
SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein (By similarity).
INDUCTION: Transactivated by SBP1.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 115.72 RPKM in Heart - Left Ventricle
Total median expression: 2645.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.7067-0.264 Picture PostScript Text
3' UTR -16.40120-0.137 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009125 - DAPIT

Pfam Domains:
PF14960 - ATP synthase regulation

ModBase Predicted Comparative 3D Structure on Q96IX5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005739 mitochondrion
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane


-  Descriptions from all associated GenBank mRNAs
  AL110185 - Homo sapiens mRNA; cDNA DKFZp566D211 (from clone DKFZp566D211).
BC091507 - Homo sapiens up-regulated during skeletal muscle growth 5 homolog (mouse), mRNA (cDNA clone MGC:111165 IMAGE:30417704), complete cds.
BC072683 - Homo sapiens up-regulated during skeletal muscle growth 5 homolog (mouse), mRNA (cDNA clone MGC:87882 IMAGE:6056764), complete cds.
AJ272056 - Homo sapiens mRNA for hypothetical protein (PD04912).
BC007087 - Homo sapiens up-regulated during skeletal muscle growth 5 homolog (mouse), mRNA (cDNA clone MGC:14697 IMAGE:4245636), complete cds.
AY740522 - Homo sapiens HCV F-transactivated protein 2 mRNA, complete cds.
AK311888 - Homo sapiens cDNA, FLJ92154, Homo sapiens upregulated during skeletal muscle growth 5 (USMG5),mRNA.
KJ895035 - Synthetic construct Homo sapiens clone ccsbBroadEn_04429 USMG5 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: ATP5MD, ATP5MK , ATPMK_HUMAN, B2R4N2, D3DR92, DAPIT, ENST00000309579.1, ENST00000309579.2, ENST00000309579.3, ENST00000309579.4, ENST00000309579.5, ENST00000309579.6, HCVFTP2, NM_001206426, PD04912, Q96IX5, uc317oof.1, uc317oof.2, USMG5
UCSC ID: ENST00000309579.7_6
RefSeq Accession: NM_001206426.2
Protein: Q96IX5 (aka USMG5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.