Human Gene ULK4 (ENST00000301831.9_7) from GENCODE V47lift37
  Description: unc-51 like kinase 4, transcript variant 4 (from RefSeq NR_136342.2)
Gencode Transcript: ENST00000301831.9_7
Gencode Gene: ENSG00000168038.11_11
Transcript (Including UTRs)
   Position: hg19 chr3:41,288,090-42,003,595 Size: 715,506 Total Exon Count: 37 Strand: -
Coding Region
   Position: hg19 chr3:41,288,420-41,996,251 Size: 707,832 Coding Exon Count: 36 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:41,288,090-42,003,595)mRNA (may differ from genome)Protein (1275 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ULK4_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase ULK4; EC=2.7.11.1; AltName: Full=Unc-51-like kinase 4;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
DOMAIN: The protein kinase domain is predicted to be catalytically inactive.
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
SIMILARITY: Contains 5 HEAT repeats.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=BAA91270.1; Type=Frameshift; Positions=489;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ULK4
Diseases sorted by gene-association score: schizophrenia (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.48 RPKM in Testis
Total median expression: 63.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.40136-0.260 Picture PostScript Text
3' UTR -106.10330-0.322 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain
48464 - ENTH/VHS domain
47954 - Cyclin-like
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q96C45
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000226 microtubule cytoskeleton organization
GO:0006468 protein phosphorylation
GO:0010975 regulation of neuron projection development
GO:0016310 phosphorylation
GO:0043408 regulation of MAPK cascade
GO:0046328 regulation of JNK cascade
GO:0090036 regulation of protein kinase C signaling
GO:1900744 regulation of p38MAPK cascade
GO:2001222 regulation of neuron migration


-  Descriptions from all associated GenBank mRNAs
  AK304341 - Homo sapiens cDNA FLJ56804 complete cds, weakly similar to Serine/threonine-protein kinase 36 (EC 2.7.11.1).
BC160098 - Synthetic construct Homo sapiens clone IMAGE:100064130, MGC:193213 unc-51-like kinase 4 (C. elegans) (ULK4) mRNA, encodes complete protein.
AK000581 - Homo sapiens cDNA FLJ20574 fis, clone REC01035.
BC014794 - Homo sapiens unc-51-like kinase 4 (C. elegans), mRNA (cDNA clone IMAGE:4343362), complete cds.
KJ902735 - Synthetic construct Homo sapiens clone ccsbBroadEn_12129 ULK4 gene, encodes complete protein.
KJ905489 - Synthetic construct Homo sapiens clone ccsbBroadEn_15087 ULK4 gene, encodes complete protein.
AK093396 - Homo sapiens cDNA FLJ36077 fis, clone TESTI2019854.
AX748099 - Sequence 1624 from Patent EP1308459.
BC040739 - Homo sapiens unc-51-like kinase 4 (C. elegans), mRNA (cDNA clone IMAGE:5743829), partial cds.
AL133104 - Homo sapiens mRNA; cDNA DKFZp434E1822 (from clone DKFZp434E1822).
BC018795 - Homo sapiens cDNA clone IMAGE:2967282.
JD259762 - Sequence 240786 from Patent EP1572962.
JD561891 - Sequence 542915 from Patent EP1572962.
JD556120 - Sequence 537144 from Patent EP1572962.
JD428906 - Sequence 409930 from Patent EP1572962.
JD403972 - Sequence 384996 from Patent EP1572962.
JD104718 - Sequence 85742 from Patent EP1572962.
JD277546 - Sequence 258570 from Patent EP1572962.
JD084273 - Sequence 65297 from Patent EP1572962.
JD063048 - Sequence 44072 from Patent EP1572962.
JD536304 - Sequence 517328 from Patent EP1572962.
JD231308 - Sequence 212332 from Patent EP1572962.
JD056019 - Sequence 37043 from Patent EP1572962.
JD326426 - Sequence 307450 from Patent EP1572962.
JD289115 - Sequence 270139 from Patent EP1572962.
JD201011 - Sequence 182035 from Patent EP1572962.
JD241264 - Sequence 222288 from Patent EP1572962.
JD266700 - Sequence 247724 from Patent EP1572962.
JD309199 - Sequence 290223 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NF15, B3KSE5, B4E2M4, ENST00000301831.1, ENST00000301831.2, ENST00000301831.3, ENST00000301831.4, ENST00000301831.5, ENST00000301831.6, ENST00000301831.7, ENST00000301831.8, NR_136342, Q8IW79, Q96C45, Q9NWV6, Q9UF96, uc317mxa.1, uc317mxa.2, ULK4_HUMAN
UCSC ID: ENST00000301831.9_7
RefSeq Accession: NM_017886.4
Protein: Q96C45 (aka ULK4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.