ID:UBR3_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase UBR3; EC=6.3.2.-; AltName: Full=N-recognin-3; AltName: Full=Ubiquitin-protein ligase E3-alpha-3; AltName: Full=Ubiquitin-protein ligase E3-alpha-III; AltName: Full=Zinc finger protein 650; FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with UBE2A and UBE2B (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the UBR1 family. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 UBR-type zinc finger. SEQUENCE CAUTION: Sequence=BAC23120.1; Type=Erroneous initiation; Sequence=BAC86783.1; Type=Erroneous initiation; Sequence=BAC87032.1; Type=Erroneous initiation; Sequence=BAG64179.1; Type=Erroneous initiation; Sequence=CAD38857.1; Type=Erroneous termination; Positions=1525; Note=Translated as Gln;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZT12
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0008270 zinc ion binding GO:0016740 transferase activity GO:0046872 metal ion binding GO:0061630 ubiquitin protein ligase activity
Biological Process: GO:0001701 in utero embryonic development GO:0001967 suckling behavior GO:0006511 ubiquitin-dependent protein catabolic process GO:0007608 sensory perception of smell GO:0009792 embryo development ending in birth or egg hatching GO:0016567 protein ubiquitination GO:0042048 olfactory behavior GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
