ID:UBE4B_HUMAN DESCRIPTION: RecName: Full=Ubiquitin conjugation factor E4 B; AltName: Full=Homozygously deleted in neuroblastoma 1; AltName: Full=Ubiquitin fusion degradation protein 2; FUNCTION: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 (By similarity). SUBUNIT: Interacts with VCP (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen. PTM: Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7. SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family. SIMILARITY: Contains 1 U-box domain. SEQUENCE CAUTION: Sequence=BAA31659.3; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95155
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0003222 ventricular trabecula myocardium morphogenesis GO:0006511 ubiquitin-dependent protein catabolic process GO:0006513 protein monoubiquitination GO:0008626 granzyme-mediated apoptotic signaling pathway GO:0009411 response to UV GO:0016567 protein ubiquitination GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0031175 neuron projection development GO:0034976 response to endoplasmic reticulum stress GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0044257 cellular protein catabolic process GO:0051865 protein autoubiquitination
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
