ID:UBS3B_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-associated and SH3 domain-containing protein B; EC=3.1.3.48; AltName: Full=Cbl-interacting protein p70; AltName: Full=Suppressor of T-cell receptor signaling 1; Short=STS-1; AltName: Full=T-cell ubiquitin ligand 2; Short=TULA-2; AltName: Full=Tyrosine-protein phosphatase STS1/TULA2; FUNCTION: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Homodimer (By similarity). Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (Potential). SIMILARITY: Contains 1 SH3 domain. SIMILARITY: Contains 1 UBA domain. SEQUENCE CAUTION: Sequence=AAL16953.1; Type=Erroneous initiation; Sequence=BAB85545.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TF42
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0005515 protein binding GO:0016787 hydrolase activity GO:0031625 ubiquitin protein ligase binding GO:0042802 identical protein binding GO:0051219 phosphoprotein binding
Biological Process: GO:0006469 negative regulation of protein kinase activity GO:0009968 negative regulation of signal transduction GO:0030168 platelet activation GO:0035335 peptidyl-tyrosine dephosphorylation GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway GO:0038065 collagen-activated signaling pathway GO:0043393 regulation of protein binding GO:0045670 regulation of osteoclast differentiation GO:0045671 negative regulation of osteoclast differentiation GO:0045779 negative regulation of bone resorption GO:0051279 regulation of release of sequestered calcium ion into cytosol GO:0070527 platelet aggregation GO:0090331 negative regulation of platelet aggregation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
