Human Gene TUBG2 (ENST00000251412.8_4) from GENCODE V47lift37
  Description: tubulin gamma 2, transcript variant 2 (from RefSeq NM_016437.3)
Gencode Transcript: ENST00000251412.8_4
Gencode Gene: ENSG00000037042.9_7
Transcript (Including UTRs)
   Position: hg19 chr17:40,811,302-40,819,024 Size: 7,723 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr17:40,811,522-40,818,818 Size: 7,297 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:40,811,302-40,819,024)mRNA (may differ from genome)Protein (451 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TBG2_HUMAN
DESCRIPTION: RecName: Full=Tubulin gamma-2 chain; AltName: Full=Gamma-2-tubulin;
FUNCTION: Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome (Probable).
PTM: Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
SIMILARITY: Belongs to the tubulin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 90.02 RPKM in Brain - Cortex
Total median expression: 1561.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -93.40220-0.425 Picture PostScript Text
3' UTR -34.90206-0.169 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002454 - Gamma_tubulin
IPR008280 - Tub_FtsZ_C
IPR000217 - Tubulin
IPR018316 - Tubulin/FtsZ_2-layer-sand-dom
IPR023123 - Tubulin_C
IPR017975 - Tubulin_CS
IPR003008 - Tubulin_FtsZ_GTPase

Pfam Domains:
PF00091 - Tubulin/FtsZ family, GTPase domain
PF03953 - Tubulin C-terminal domain

SCOP Domains:
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9NRH3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
     Gene Details
     Gene Sorter
     SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005198 structural molecule activity
GO:0005525 GTP binding

Biological Process:
GO:0007017 microtubule-based process
GO:0007020 microtubule nucleation
GO:0031122 cytoplasmic microtubule organization

Cellular Component:
GO:0000242 pericentriolar material
GO:0000930 gamma-tubulin complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0005881 cytoplasmic microtubule
GO:0015630 microtubule cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  BC108739 - Homo sapiens tubulin, gamma 2, mRNA (cDNA clone MGC:131994 IMAGE:5242733), complete cds.
AK225134 - Homo sapiens mRNA for tubulin, gamma 2 variant, clone: CBL03241.
AF225971 - Homo sapiens gamma-tubulin (TUBG2) mRNA, complete cds.
BC051890 - Homo sapiens tubulin, gamma 2, mRNA (cDNA clone MGC:60302 IMAGE:5726689), complete cds.
BC052283 - Homo sapiens tubulin, gamma 2, mRNA (cDNA clone IMAGE:5458158), containing frame-shift errors.
AK022324 - Homo sapiens cDNA FLJ12262 fis, clone MAMMA1001576, highly similar to Human gamma-tubulin mRNA.
BC009670 - Homo sapiens tubulin, gamma 2, mRNA (cDNA clone MGC:8716 IMAGE:3891214), complete cds.
AK295569 - Homo sapiens cDNA FLJ53044 complete cds, highly similar to Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15).
CU679431 - Synthetic construct Homo sapiens gateway clone IMAGE:100017299 5' read TUBG2 mRNA.
KJ893607 - Synthetic construct Homo sapiens clone ccsbBroadEn_03001 TUBG2 gene, encodes complete protein.
AB464326 - Synthetic construct DNA, clone: pF1KB8127, Homo sapiens TUBG2 gene for tubulin, gamma 2, without stop codon, in Flexi system.
LC047806 - Homo sapiens TUBG2 mRNA for tubulin gamma 2 chain, complete cds.
AK310562 - Homo sapiens cDNA, FLJ17604.
LF327902 - JP 2014500723-A/135405: Polycomb-Associated Non-Coding RNAs.
LF327903 - JP 2014500723-A/135406: Polycomb-Associated Non-Coding RNAs.
LF327904 - JP 2014500723-A/135407: Polycomb-Associated Non-Coding RNAs.
LF327905 - JP 2014500723-A/135408: Polycomb-Associated Non-Coding RNAs.
LF327906 - JP 2014500723-A/135409: Polycomb-Associated Non-Coding RNAs.
LF327896 - JP 2014500723-A/135399: Polycomb-Associated Non-Coding RNAs.
LF327897 - JP 2014500723-A/135400: Polycomb-Associated Non-Coding RNAs.
LF327907 - JP 2014500723-A/135410: Polycomb-Associated Non-Coding RNAs.
JD109392 - Sequence 90416 from Patent EP1572962.
JD550926 - Sequence 531950 from Patent EP1572962.
JD419091 - Sequence 400115 from Patent EP1572962.
JD262308 - Sequence 243332 from Patent EP1572962.
MA563479 - JP 2018138019-A/135405: Polycomb-Associated Non-Coding RNAs.
MA563480 - JP 2018138019-A/135406: Polycomb-Associated Non-Coding RNAs.
MA563481 - JP 2018138019-A/135407: Polycomb-Associated Non-Coding RNAs.
MA563482 - JP 2018138019-A/135408: Polycomb-Associated Non-Coding RNAs.
MA563483 - JP 2018138019-A/135409: Polycomb-Associated Non-Coding RNAs.
MA563473 - JP 2018138019-A/135399: Polycomb-Associated Non-Coding RNAs.
MA563474 - JP 2018138019-A/135400: Polycomb-Associated Non-Coding RNAs.
MA563484 - JP 2018138019-A/135410: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NRH3 (Reactome details) participates in the following event(s):

R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
R-HSA-380508 Translocation of NuMA to the centrosomes
R-HSA-380316 Association of NuMA with microtubules
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-380287 Centrosome maturation
R-HSA-68877 Mitotic Prometaphase
R-HSA-69275 G2/M Transition
R-HSA-68886 M Phase
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: A6NDI4, ENST00000251412.1, ENST00000251412.2, ENST00000251412.3, ENST00000251412.4, ENST00000251412.5, ENST00000251412.6, ENST00000251412.7, NM_016437, Q32NB2, Q9NRH3, TBG2_HUMAN, uc317fea.1, uc317fea.2
UCSC ID: ENST00000251412.8_4
RefSeq Accession: NM_016437.3
Protein: Q9NRH3 (aka TBG2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.