Human Gene TRRAP (ENST00000456197.2_13) from GENCODE V47lift37
  Description: transformation/transcription domain associated protein, transcript variant 3 (from RefSeq NM_001375524.1)
Gencode Transcript: ENST00000456197.2_13
Gencode Gene: ENSG00000196367.15_17
Transcript (Including UTRs)
   Position: hg19 chr7:98,476,155-98,610,864 Size: 134,710 Total Exon Count: 73 Strand: +
Coding Region
   Position: hg19 chr7:98,478,774-98,609,978 Size: 131,205 Coding Exon Count: 72 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:98,476,155-98,610,864)mRNA (may differ from genome)Protein (3873 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: H0Y4W2_HUMAN
DESCRIPTION: SubName: Full=Transformation/transcription domain-associated protein; Flags: Fragment;
SIMILARITY: Contains 1 FAT domain.
SIMILARITY: Contains 1 FATC domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TRRAP
Diseases sorted by gene-association score: lung large cell carcinoma (16), splenic marginal zone lymphoma (7), spinocerebellar ataxia 7 (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.14 RPKM in Pituitary
Total median expression: 299.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.20167-0.468 Picture PostScript Text
3' UTR -255.50886-0.288 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR003152 - FATC
IPR011009 - Kinase-like_dom
IPR000403 - PI3/4_kinase_cat_dom
IPR003151 - PIK-rel_kinase_FAT
IPR014009 - PIK_FAT
IPR011990 - TPR-like_helical

Pfam Domains:
PF00454 - Phosphatidylinositol 3- and 4-kinase
PF02259 - FAT domain

SCOP Domains:
48371 - ARM repeat
48452 - TPR-like
101447 - Formin homology 2 domain (FH2 domain)
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on H0Y4W2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  Ensembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0016310 phosphorylation
GO:0016573 histone acetylation

Cellular Component:
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus


-  Descriptions from all associated GenBank mRNAs
  AF076974 - Homo sapiens TRRAP protein (TRRAP) mRNA, complete cds.
AF110377 - Homo sapiens PCAF-associated factor 400 (PAF400) mRNA, complete cds.
AB209489 - Homo sapiens mRNA for Transformation/transcription domain-associated protein variant protein.
BC172895 - Synthetic construct Homo sapiens clone IMAGE:9094471 transformation/transcription domain-associated protein (TRRAP) gene, partial cds.
JD322491 - Sequence 303515 from Patent EP1572962.
BC172904 - Synthetic construct Homo sapiens clone IMAGE:9094480 transformation/transcription domain-associated protein (TRRAP) gene, partial cds.
DQ576258 - Homo sapiens piRNA piR-44370, complete sequence.
BC172896 - Synthetic construct Homo sapiens clone IMAGE:9094472 transformation/transcription domain-associated protein (TRRAP) gene, partial cds.
JD389901 - Sequence 370925 from Patent EP1572962.
JD170567 - Sequence 151591 from Patent EP1572962.
JD217555 - Sequence 198579 from Patent EP1572962.
AL050077 - Homo sapiens mRNA; cDNA DKFZp566G1746 (from clone DKFZp566G1746).
JD349574 - Sequence 330598 from Patent EP1572962.
JD555908 - Sequence 536932 from Patent EP1572962.
DQ593524 - Homo sapiens piRNA piR-33636, complete sequence.
JD160332 - Sequence 141356 from Patent EP1572962.
BC032759 - Homo sapiens transformation/transcription domain-associated protein, mRNA (cDNA clone IMAGE:3452385), partial cds.
JD317688 - Sequence 298712 from Patent EP1572962.
JD504836 - Sequence 485860 from Patent EP1572962.
JD484605 - Sequence 465629 from Patent EP1572962.
JD326647 - Sequence 307671 from Patent EP1572962.
JD494455 - Sequence 475479 from Patent EP1572962.
JD258636 - Sequence 239660 from Patent EP1572962.
JD202000 - Sequence 183024 from Patent EP1572962.
AK001533 - Homo sapiens cDNA FLJ10671 fis, clone NT2RP2006333.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000456197.1, H0Y4W2, H0Y4W2_HUMAN, NM_001375524, TRRAP , uc320xfc.1, uc320xfc.2
UCSC ID: ENST00000456197.2_13
RefSeq Accession: NM_001375524.1
Protein: H0Y4W2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.