Human Gene TRAF3IP3 (ENST00000367025.8_10) from GENCODE V47lift37
  Description: TRAF3 interacting protein 3, transcript variant 1 (from RefSeq NM_025228.4)
Gencode Transcript: ENST00000367025.8_10
Gencode Gene: ENSG00000009790.15_14
Transcript (Including UTRs)
   Position: hg19 chr1:209,929,398-209,955,655 Size: 26,258 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr1:209,933,385-209,955,493 Size: 22,109 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:209,929,398-209,955,655)mRNA (may differ from genome)Protein (551 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T3JAM_HUMAN
DESCRIPTION: RecName: Full=TRAF3-interacting JNK-activating modulator; AltName: Full=TRAF3-interacting protein 3;
FUNCTION: May function as an adapter molecule that regulates TRAF3-mediated JNK activation (By similarity).
SUBUNIT: Binds to the isoleucine zipper of TRAF3 via its coiled- coil domain (By similarity).
INTERACTION: Q5VSL9:FAM40A; NbExp=2; IntAct=EBI-765817, EBI-1773588; Q9Y3A3:MOB4; NbExp=2; IntAct=EBI-765817, EBI-713935; Q9BRV8:SIKE1; NbExp=2; IntAct=EBI-765817, EBI-1773646; Q9Y6E0:STK24; NbExp=2; IntAct=EBI-765817, EBI-740175; O43815:STRN; NbExp=2; IntAct=EBI-765817, EBI-1046642; Q13033:STRN3; NbExp=2; IntAct=EBI-765817, EBI-1053857;
SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.43 RPKM in Spleen
Total median expression: 112.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.60416-0.357 Picture PostScript Text
3' UTR -29.10162-0.180 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  SCOP Domains:
58042 - Outer membrane lipoprotein
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on Q9Y228
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK122792 - Homo sapiens cDNA FLJ16356 fis, clone THYMU2003891, weakly similar to Oryctolagus cuniculus sarcolemmal associated protein-3 mRNA.
BX648450 - Homo sapiens mRNA; cDNA DKFZp686C0363 (from clone DKFZp686C0363).
BC110302 - Homo sapiens TRAF3 interacting protein 3, mRNA (cDNA clone MGC:117354 IMAGE:5219542), complete cds.
AK300555 - Homo sapiens cDNA FLJ52976 complete cds, highly similar to TRAF3-interacting JNK-activating modulator.
AK312755 - Homo sapiens cDNA, FLJ93165.
AK225762 - Homo sapiens mRNA for TRAF3-interacting JNK-activating modulator variant, clone: FCC134D12.
AL049667 - Human gene from PAC 434O14, chromosome 1.
JD183743 - Sequence 164767 from Patent EP1572962.
JD038620 - Sequence 19644 from Patent EP1572962.
JD431807 - Sequence 412831 from Patent EP1572962.
AK125601 - Homo sapiens cDNA FLJ43613 fis, clone SPLEN2015679, highly similar to TRAF3-interacting JNK-activating modulator.
BC130417 - Homo sapiens TRAF3 interacting protein 3, mRNA (cDNA clone MGC:163289 IMAGE:40146448), complete cds.
BC144139 - Homo sapiens TRAF3 interacting protein 3, mRNA (cDNA clone MGC:177676 IMAGE:9052659), complete cds.
JD539328 - Sequence 520352 from Patent EP1572962.
KJ903303 - Synthetic construct Homo sapiens clone ccsbBroadEn_12697 TRAF3IP3 gene, encodes complete protein.
KJ899639 - Synthetic construct Homo sapiens clone ccsbBroadEn_09033 TRAF3IP3 gene, encodes complete protein.
HQ258296 - Synthetic construct Homo sapiens clone IMAGE:100072605 Unknown protein gene, encodes complete protein.
KP890302 - Homo sapiens isolate WY-2015305 TRAF3 interacting protein 3 (TRAF3IP3) mRNA, complete cds.
AK126139 - Homo sapiens cDNA FLJ44151 fis, clone THYMU2031218.
AK092905 - Homo sapiens cDNA FLJ35586 fis, clone SPLEN2007326.
JD095582 - Sequence 76606 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A1L464, A6NIU9, ENST00000367025.1, ENST00000367025.2, ENST00000367025.3, ENST00000367025.4, ENST00000367025.5, ENST00000367025.6, ENST00000367025.7, NM_025228, Q2YDB5, Q4VY06, Q7Z706, Q9Y228, T3JAM, T3JAM_HUMAN, uc318fok.1, uc318fok.2
UCSC ID: ENST00000367025.8_10
RefSeq Accession: NM_025228.4
Protein: Q9Y228 (aka T3JAM_HUMAN or TJAM_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.