ID:PERT_HUMAN DESCRIPTION: RecName: Full=Thyroid peroxidase; Short=TPO; EC=1.11.1.8; Flags: Precursor; FUNCTION: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). CATALYTIC ACTIVITY: 2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O. COFACTOR: Binds 1 calcium ion per heterodimer (By similarity). COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer (By similarity). PATHWAY: Hormone biosynthesis; thyroid hormone biosynthesis. SUBUNIT: Interacts with DUOX1, DUOX2 and CYBA. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 3: Cell surface. PTM: Glycosylated. PTM: Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface. PTM: Cleaved in its N-terminal part. DISEASE: Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease. DISEASE: Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]. A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. SIMILARITY: Belongs to the peroxidase family. XPO subfamily. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 Sushi (CCP/SCR) domain. WEB RESOURCE: Name=Wikipedia; Note=Thyroid peroxidase entry; URL="http://en.wikipedia.org/wiki/Thyroid_peroxidase";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P07202
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
