ID:TPC1_HUMAN DESCRIPTION: RecName: Full=Two pore calcium channel protein 1; AltName: Full=Voltage-dependent calcium channel protein TPC1; FUNCTION: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. SUBUNIT: Dimer (Potential). INTERACTION: Self; NbExp=3; IntAct=EBI-5239895, EBI-5239895; Q8NHX9:TPCN2; NbExp=9; IntAct=EBI-5239895, EBI-5239949; SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highest expression found in the heart and kidney, and lowest expression found in the spleen. DOMAIN: Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity). SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. SEQUENCE CAUTION: Sequence=AK057414; Type=Frameshift; Positions=273; Sequence=BAA86483.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULQ1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005245 voltage-gated calcium channel activity GO:0005262 calcium channel activity GO:0005515 protein binding GO:0042802 identical protein binding GO:0072345 NAADP-sensitive calcium-release channel activity
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0010508 positive regulation of autophagy GO:0034220 ion transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0051209 release of sequestered calcium ion into cytosol GO:0055085 transmembrane transport GO:0070588 calcium ion transmembrane transport GO:0086010 membrane depolarization during action potential
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
