ID:TNIK_HUMAN DESCRIPTION: RecName: Full=TRAF2 and NCK-interacting protein kinase; EC=2.7.11.1; FUNCTION: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1. INTERACTION: Q6F6B3:Tanc1 (xeno); NbExp=2; IntAct=EBI-1051794, EBI-2133582; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression. TISSUE SPECIFICITY: Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. PTM: Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 CNH domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAA25477.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UKE5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000185 activation of MAPKKK activity GO:0001934 positive regulation of protein phosphorylation GO:0006468 protein phosphorylation GO:0007010 cytoskeleton organization GO:0007256 activation of JNKK activity GO:0007346 regulation of mitotic cell cycle GO:0007399 nervous system development GO:0016055 Wnt signaling pathway GO:0016310 phosphorylation GO:0030033 microvillus assembly GO:0031532 actin cytoskeleton reorganization GO:0035556 intracellular signal transduction GO:0042981 regulation of apoptotic process GO:0046777 protein autophosphorylation GO:0048814 regulation of dendrite morphogenesis GO:0072659 protein localization to plasma membrane
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
