Human Gene TMEM68 (ENST00000334667.6_6) from GENCODE V47lift37
  Description: transmembrane protein 68, transcript variant 2 (from RefSeq NM_152417.3)
Gencode Transcript: ENST00000334667.6_6
Gencode Gene: ENSG00000167904.16_20
Transcript (Including UTRs)
   Position: hg19 chr8:56,651,317-56,685,966 Size: 34,650 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr8:56,652,691-56,675,518 Size: 22,828 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:56,651,317-56,685,966)mRNA (may differ from genome)Protein (257 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMM68_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 68;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.67 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 103.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.60253-0.271 Picture PostScript Text
3' UTR -301.801374-0.220 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002123 - Acyltransferase

Pfam Domains:
PF01553 - Acyltransferase

SCOP Domains:
69593 - Glycerol-3-phosphate (1)-acyltransferase

ModBase Predicted Comparative 3D Structure on Q96MH6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016746 transferase activity, transferring acyl groups

Biological Process:
GO:0008152 metabolic process

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ903799 - Synthetic construct Homo sapiens clone ccsbBroadEn_13193 TMEM68 gene, encodes complete protein.
BC043417 - Homo sapiens transmembrane protein 68, mRNA (cDNA clone IMAGE:5286539), complete cds.
AL832935 - Homo sapiens mRNA; cDNA DKFZp666D0510 (from clone DKFZp666D0510).
AK056932 - Homo sapiens cDNA FLJ32370 fis, clone PUAEN1000322.
JD415131 - Sequence 396155 from Patent EP1572962.
JD069827 - Sequence 50851 from Patent EP1572962.
JD514006 - Sequence 495030 from Patent EP1572962.
JD233513 - Sequence 214537 from Patent EP1572962.
JD188366 - Sequence 169390 from Patent EP1572962.
JD362554 - Sequence 343578 from Patent EP1572962.
BC071636 - Homo sapiens transmembrane protein 68, mRNA (cDNA clone MGC:87778 IMAGE:5193338), complete cds.
AK308247 - Homo sapiens cDNA, FLJ98195.
AF147306 - Homo sapiens full length insert cDNA clone YA80D10.
BC020835 - Homo sapiens transmembrane protein 68, mRNA (cDNA clone MGC:23925 IMAGE:4806471), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: DIESL_HUMAN, ENST00000334667.1, ENST00000334667.2, ENST00000334667.3, ENST00000334667.4, ENST00000334667.5, NM_152417, Q658X6, Q8WUD2, Q96MH6, TMEM68 , uc317uax.1, uc317uax.2
UCSC ID: ENST00000334667.6_6
RefSeq Accession: NM_152417.3
Protein: Q96MH6 (aka TMM68_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.