Human Gene TMEM175 (ENST00000264771.9_4) from GENCODE V47lift37
  Description: transmembrane protein 175, transcript variant 1 (from RefSeq NM_032326.4)
Gencode Transcript: ENST00000264771.9_4
Gencode Gene: ENSG00000127419.17_13
Transcript (Including UTRs)
   Position: hg19 chr4:926,248-952,444 Size: 26,197 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr4:941,528-952,284 Size: 10,757 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:926,248-952,444)mRNA (may differ from genome)Protein (504 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM175_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 175;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM175 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.48 RPKM in Brain - Cerebellum
Total median expression: 922.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.80112-0.436 Picture PostScript Text
3' UTR -52.50160-0.328 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010617 - DUF1211_TMEM175

Pfam Domains:
PF06736 - Endosomal/lysosomal potassium channel TMEM175

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains

ModBase Predicted Comparative 3D Structure on Q9BSA9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005267 potassium channel activity
GO:0022841 potassium ion leak channel activity

Biological Process:
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0035751 regulation of lysosomal lumen pH
GO:0071805 potassium ion transmembrane transport
GO:0090385 phagosome-lysosome fusion

Cellular Component:
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK293641 - Homo sapiens cDNA FLJ56657 complete cds.
AK090848 - Homo sapiens cDNA FLJ33529 fis, clone BRAMY2007244.
AX746646 - Sequence 171 from Patent EP1308459.
AK309132 - Homo sapiens cDNA, FLJ99173.
BC047738 - Homo sapiens transmembrane protein 175, mRNA (cDNA clone IMAGE:5755913), with apparent retained intron.
BC005158 - Homo sapiens transmembrane protein 175, mRNA (cDNA clone MGC:4618 IMAGE:3505819), complete cds.
BC063488 - Homo sapiens hypothetical protein MGC4618, mRNA (cDNA clone IMAGE:5240747), partial cds.
BC095416 - Homo sapiens transmembrane protein 175, mRNA (cDNA clone IMAGE:4799102), with apparent retained intron.
AL834199 - Homo sapiens mRNA; cDNA DKFZp547K246 (from clone DKFZp547K246).
DQ896164 - Synthetic construct Homo sapiens clone IMAGE:100010624; FLH190788.01L; RZPDo839E0166D hypothetical protein MGC4618 (MGC4618) gene, encodes complete protein.
DQ892915 - Synthetic construct clone IMAGE:100005545; FLH190792.01X; RZPDo839E0176D hypothetical protein MGC4618 (MGC4618) gene, encodes complete protein.
KJ894963 - Synthetic construct Homo sapiens clone ccsbBroadEn_04357 TMEM175 gene, encodes complete protein.
BC118552 - Homo sapiens hypothetical LOC285456, mRNA (cDNA clone IMAGE:40022352).
JD390947 - Sequence 371971 from Patent EP1572962.
JD189133 - Sequence 170157 from Patent EP1572962.
JD456721 - Sequence 437745 from Patent EP1572962.
JD104928 - Sequence 85952 from Patent EP1572962.
JD513305 - Sequence 494329 from Patent EP1572962.
JD470397 - Sequence 451421 from Patent EP1572962.
JD384057 - Sequence 365081 from Patent EP1572962.
JD046534 - Sequence 27558 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DVN4, ENST00000264771.1, ENST00000264771.2, ENST00000264771.3, ENST00000264771.4, ENST00000264771.5, ENST00000264771.6, ENST00000264771.7, ENST00000264771.8, NM_032326, Q8ND13, Q9BSA9, TM175_HUMAN, TMEM175 , uc317hvk.1, uc317hvk.2
UCSC ID: ENST00000264771.9_4
RefSeq Accession: NM_032326.4
Protein: Q9BSA9 (aka TM175_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.