ID:TMM17_HUMAN DESCRIPTION: RecName: Full=Transmembrane protein 17; FUNCTION: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). SUBUNIT: Part of the tectonic-like complex (also named B9 complex) (By similarity). SUBCELLULAR LOCATION: Cell projection, cilium membrane; Multi-pass membrane protein (By similarity). Note=Localizes to the transition zone of primary cilia (By similarity). SIMILARITY: Belongs to the TMEM17 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09799 - Predicted membrane protein
ModBase Predicted Comparative 3D Structure on Q86X19
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
