Human Gene TMA16 (ENST00000358572.10_5) from GENCODE V47lift37
  Description: translation machinery associated 16 homolog (from RefSeq NM_018352.3)
Gencode Transcript: ENST00000358572.10_5
Gencode Gene: ENSG00000198498.10_8
Transcript (Including UTRs)
   Position: hg19 chr4:164,415,842-164,441,691 Size: 25,850 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr4:164,415,954-164,440,666 Size: 24,713 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:164,415,842-164,441,691)mRNA (may differ from genome)Protein (203 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMA16_HUMAN
DESCRIPTION: RecName: Full=Translation machinery-associated protein 16;
SIMILARITY: Belongs to the UPF0534 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.86 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 288.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.30112-0.485 Picture PostScript Text
3' UTR -211.801025-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021346 - DUF2962

Pfam Domains:
PF11176 - Translation machinery-associated protein 16

ModBase Predicted Comparative 3D Structure on Q96EY4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005840 ribosome


-  Descriptions from all associated GenBank mRNAs
  BC017418 - Homo sapiens chromosome 4 open reading frame 43, mRNA (cDNA clone IMAGE:4672457), containing frame-shift errors.
AK298235 - Homo sapiens cDNA FLJ52950 complete cds.
BC005204 - Homo sapiens chromosome 4 open reading frame 43, mRNA (cDNA clone IMAGE:3829877), containing frame-shift errors.
AK002046 - Homo sapiens cDNA FLJ11184 fis, clone PLACE1007507.
BC011842 - Homo sapiens chromosome 4 open reading frame 43, mRNA (cDNA clone MGC:19960 IMAGE:4110177), complete cds.
JD271752 - Sequence 252776 from Patent EP1572962.
JD531800 - Sequence 512824 from Patent EP1572962.
CU680078 - Synthetic construct Homo sapiens gateway clone IMAGE:100017583 5' read FLJ11184 mRNA.
HQ448694 - Synthetic construct Homo sapiens clone IMAGE:100072138; CCSB007055_04 hypothetical protein FLJ11184 (FLJ11184) gene, encodes complete protein.
KJ899121 - Synthetic construct Homo sapiens clone ccsbBroadEn_08515 TMA16 gene, encodes complete protein.
JD552446 - Sequence 533470 from Patent EP1572962.
JD531114 - Sequence 512138 from Patent EP1572962.
JD245351 - Sequence 226375 from Patent EP1572962.
JD158299 - Sequence 139323 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C4orf43, ENST00000358572.1, ENST00000358572.2, ENST00000358572.3, ENST00000358572.4, ENST00000358572.5, ENST00000358572.6, ENST00000358572.7, ENST00000358572.8, ENST00000358572.9, NM_018352, Q0P6E4, Q0P6J1, Q96EY4, Q9NUR7, TMA16_HUMAN, uc318apx.1, uc318apx.2
UCSC ID: ENST00000358572.10_5
RefSeq Accession: NM_018352.3
Protein: Q96EY4 (aka TMA16_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.