Human Gene TIPRL (ENST00000367833.7_4) from GENCODE V47lift37
  Description: TOR signaling pathway regulator, transcript variant 1 (from RefSeq NM_152902.5)
Gencode Transcript: ENST00000367833.7_4
Gencode Gene: ENSG00000143155.13_7
Transcript (Including UTRs)
   Position: hg19 chr1:168,148,200-168,171,347 Size: 23,148 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr1:168,148,316-168,169,284 Size: 20,969 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:168,148,200-168,171,347)mRNA (may differ from genome)Protein (272 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TIPRL_HUMAN
DESCRIPTION: RecName: Full=TIP41-like protein; AltName: Full=Putative MAPK-activating protein PM10; AltName: Full=Type 2A-interacting protein; Short=TIP;
FUNCTION: May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
SUBUNIT: Isoform 1 interacts with PPP2CA. Isoform 2 does not interact with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):alpha-4 complex.
INTERACTION: P60510:PPP4C; NbExp=2; IntAct=EBI-1054735, EBI-1046072;
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the TIP41 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.57 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 530.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.10116-0.432 Picture PostScript Text
3' UTR -522.802063-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007303 - TIP41-like

Pfam Domains:
PF04176 - TIP41-like family

ModBase Predicted Comparative 3D Structure on O75663
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0000077 DNA damage checkpoint
GO:0032515 negative regulation of phosphoprotein phosphatase activity

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK313520 - Homo sapiens cDNA, FLJ94078.
AL049670 - Human gene from PAC 69E11, chromosome 1.
AB097034 - Homo sapiens mRNA for putative MAPK activating protein, complete cds, clone: PM10.
JD241636 - Sequence 222660 from Patent EP1572962.
JD476247 - Sequence 457271 from Patent EP1572962.
JD458870 - Sequence 439894 from Patent EP1572962.
JD166075 - Sequence 147099 from Patent EP1572962.
BC009506 - Homo sapiens TIP41, TOR signaling pathway regulator-like (S. cerevisiae), mRNA (cDNA clone MGC:3794 IMAGE:3532344), complete cds.
KJ900533 - Synthetic construct Homo sapiens clone ccsbBroadEn_09927 TIPRL gene, encodes complete protein.
BX648646 - Homo sapiens mRNA; cDNA DKFZp686C19117 (from clone DKFZp686C19117).
JD060266 - Sequence 41290 from Patent EP1572962.
JD039754 - Sequence 20778 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R8V3, ENST00000367833.1, ENST00000367833.2, ENST00000367833.3, ENST00000367833.4, ENST00000367833.5, ENST00000367833.6, NM_152902, O75663, Q5HYB2, Q8IZ86, TIPRL_HUMAN, uc318gfv.1, uc318gfv.2
UCSC ID: ENST00000367833.7_4
RefSeq Accession: NM_152902.5
Protein: O75663 (aka TIPRL_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.