Human Gene THRAP3 (ENST00000354618.10_6) from GENCODE V47lift37
  Description: thyroid hormone receptor associated protein 3, transcript variant 1 (from RefSeq NM_005119.4)
Gencode Transcript: ENST00000354618.10_6
Gencode Gene: ENSG00000054118.15_10
Transcript (Including UTRs)
   Position: hg19 chr1:36,690,044-36,770,958 Size: 80,915 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr1:36,748,165-36,769,618 Size: 21,454 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:36,690,044-36,770,958)mRNA (may differ from genome)Protein (955 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TR150_HUMAN
DESCRIPTION: RecName: Full=Thyroid hormone receptor-associated protein 3; AltName: Full=Thyroid hormone receptor-associated protein complex 150 kDa component; Short=Trap150;
FUNCTION: Plays a role in transcriptional coactivation.
SUBUNIT: Subunit of the large multiprotein complex TRAP.
SUBCELLULAR LOCATION: Nucleus (Potential).
TISSUE SPECIFICITY: Ubiquitous.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SEQUENCE CAUTION: Sequence=AAH37554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.22 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1412.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.30197-0.276 Picture PostScript Text
3' UTR -400.101340-0.299 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026667 - THRAP3

Pfam Domains:
PF15440 - THRAP3/BCLAF1 family

ModBase Predicted Comparative 3D Structure on Q9Y2W1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0038023 signaling receptor activity
GO:0042809 vitamin D receptor binding
GO:0046966 thyroid hormone receptor binding
GO:0051219 phosphoprotein binding

Biological Process:
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0007623 circadian rhythm
GO:0008380 RNA splicing
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0042753 positive regulation of circadian rhythm
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0048255 mRNA stabilization
GO:0048511 rhythmic process

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016592 mediator complex
GO:0016607 nuclear speck
GO:0070062 extracellular exosome
GO:0035145 exon-exon junction complex


-  Descriptions from all associated GenBank mRNAs
  BC065519 - Homo sapiens thyroid hormone receptor associated protein 3, mRNA (cDNA clone IMAGE:5787102), partial cds.
BC010997 - Homo sapiens thyroid hormone receptor associated protein 3, mRNA (cDNA clone IMAGE:3956862), partial cds.
BC002501 - Homo sapiens thyroid hormone receptor associated protein 3, mRNA (cDNA clone IMAGE:3050423), partial cds.
AF117756 - Homo sapiens thyroid hormone receptor-associated protein complex component TRAP150 mRNA, complete cds.
BC019076 - Homo sapiens thyroid hormone receptor associated protein 3, mRNA (cDNA clone IMAGE:3834482), partial cds.
BC112330 - Homo sapiens thyroid hormone receptor associated protein 3, mRNA (cDNA clone MGC:133082 IMAGE:40012311), complete cds.
BC112350 - Homo sapiens thyroid hormone receptor associated protein 3, mRNA (cDNA clone MGC:133083 IMAGE:40012315), complete cds.
JD480590 - Sequence 461614 from Patent EP1572962.
BC054046 - Homo sapiens thyroid hormone receptor associated protein 3, mRNA (cDNA clone IMAGE:6147798), partial cds.
BC037554 - Homo sapiens thyroid hormone receptor associated protein 3, mRNA (cDNA clone IMAGE:4939866), partial cds.
EU446755 - Synthetic construct Homo sapiens clone IMAGE:100070363; IMAGE:100011964; FLH258380.01L thyroid hormone receptor associated protein 3 (THRAP3) gene, encodes complete protein.
KJ892884 - Synthetic construct Homo sapiens clone ccsbBroadEn_02278 THRAP3 gene, encodes complete protein.
JD021115 - Sequence 2139 from Patent EP1572962.
JD032741 - Sequence 13765 from Patent EP1572962.
AK025735 - Homo sapiens cDNA: FLJ22082 fis, clone HEP14032, highly similar to AF117756 Homo sapiens thyroid hormone receptor-associated protein complex component TRAP150 mRNA.
JD183603 - Sequence 164627 from Patent EP1572962.
JD065854 - Sequence 46878 from Patent EP1572962.
JD484665 - Sequence 465689 from Patent EP1572962.
JD057087 - Sequence 38111 from Patent EP1572962.
JD278606 - Sequence 259630 from Patent EP1572962.
JD082088 - Sequence 63112 from Patent EP1572962.
JD552113 - Sequence 533137 from Patent EP1572962.
JD024192 - Sequence 5216 from Patent EP1572962.
JD032448 - Sequence 13472 from Patent EP1572962.
AK025408 - Homo sapiens cDNA: FLJ21755 fis, clone COLF6647.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y2W1 (Reactome details) participates in the following event(s):

R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: BCLAF2 , D3DPS5, ENST00000354618.1, ENST00000354618.2, ENST00000354618.3, ENST00000354618.4, ENST00000354618.5, ENST00000354618.6, ENST00000354618.7, ENST00000354618.8, ENST00000354618.9, NM_005119, Q5VTK6, Q9Y2W1, THRAP3 , TR150_HUMAN, TRAP150, uc317ysg.1, uc317ysg.2
UCSC ID: ENST00000354618.10_6
RefSeq Accession: NM_005119.4
Protein: Q9Y2W1 (aka TR150_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.