Human Gene THEM6 (ENST00000336138.4_4) from GENCODE V47lift37
  Description: thioesterase superfamily member 6, transcript variant 1 (from RefSeq NM_016647.3)
Gencode Transcript: ENST00000336138.4_4
Gencode Gene: ENSG00000130193.8_7
Transcript (Including UTRs)
   Position: hg19 chr8:143,808,641-143,818,345 Size: 9,705 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr8:143,808,765-143,816,857 Size: 8,093 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:143,808,641-143,818,345)mRNA (may differ from genome)Protein (208 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: THEM6_HUMAN
DESCRIPTION: RecName: Full=UPF0670 protein THEM6; AltName: Full=Mesenchymal stem cell protein DSCD75; AltName: Full=Thioesterase superfamily member 6; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the UPF0670 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: THEM6
Diseases sorted by gene-association score: discharging ear (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.03 RPKM in Liver
Total median expression: 479.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.30124-0.478 Picture PostScript Text
3' UTR -713.501488-0.480 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF13279 - Thioesterase-like superfamily

SCOP Domains:
54637 - Thioesterase/thiol ester dehydrase-isomerase

ModBase Predicted Comparative 3D Structure on Q8WUY1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  KJ905471 - Synthetic construct Homo sapiens clone ccsbBroadEn_15064 C8orf55 gene, encodes complete protein.
LF212608 - JP 2014500723-A/20111: Polycomb-Associated Non-Coding RNAs.
BC001311 - Homo sapiens chromosome 8 open reading frame 55, mRNA (cDNA clone MGC:5515 IMAGE:3453935), complete cds.
LF210308 - JP 2014500723-A/17811: Polycomb-Associated Non-Coding RNAs.
AK301564 - Homo sapiens cDNA FLJ54968 complete cds.
AK315614 - Homo sapiens cDNA, FLJ96695, Homo sapiens mesenchymal stem cell protein DSCD75 (LOC51337), mRNA.
AF242773 - Homo sapiens mesenchymal stem cell protein DSCD75 mRNA, complete cds.
BC019104 - Homo sapiens chromosome 8 open reading frame 55, mRNA (cDNA clone MGC:29501 IMAGE:5021156), complete cds.
JD451985 - Sequence 433009 from Patent EP1572962.
AK075407 - Homo sapiens cDNA PSEC0098 fis, clone NT2RP2002695, highly similar to Mesenchymal stem cell protein DSCD75.
AK055140 - Homo sapiens cDNA FLJ30578 fis, clone BRAWH2006960.
LF210309 - JP 2014500723-A/17812: Polycomb-Associated Non-Coding RNAs.
LF337027 - JP 2014500723-A/144530: Polycomb-Associated Non-Coding RNAs.
JD271261 - Sequence 252285 from Patent EP1572962.
JD143595 - Sequence 124619 from Patent EP1572962.
JD544377 - Sequence 525401 from Patent EP1572962.
JD098144 - Sequence 79168 from Patent EP1572962.
JD385600 - Sequence 366624 from Patent EP1572962.
JD133853 - Sequence 114877 from Patent EP1572962.
JD117684 - Sequence 98708 from Patent EP1572962.
JD207345 - Sequence 188369 from Patent EP1572962.
JD277572 - Sequence 258596 from Patent EP1572962.
JD066472 - Sequence 47496 from Patent EP1572962.
JD130859 - Sequence 111883 from Patent EP1572962.
LF337028 - JP 2014500723-A/144531: Polycomb-Associated Non-Coding RNAs.
JD460221 - Sequence 441245 from Patent EP1572962.
JD401315 - Sequence 382339 from Patent EP1572962.
JD523846 - Sequence 504870 from Patent EP1572962.
JD367532 - Sequence 348556 from Patent EP1572962.
JD418341 - Sequence 399365 from Patent EP1572962.
JD266576 - Sequence 247600 from Patent EP1572962.
JD426155 - Sequence 407179 from Patent EP1572962.
JD483142 - Sequence 464166 from Patent EP1572962.
JD545703 - Sequence 526727 from Patent EP1572962.
JD492435 - Sequence 473459 from Patent EP1572962.
JD459142 - Sequence 440166 from Patent EP1572962.
JD408884 - Sequence 389908 from Patent EP1572962.
JD332965 - Sequence 313989 from Patent EP1572962.
JD354994 - Sequence 336018 from Patent EP1572962.
JD539397 - Sequence 520421 from Patent EP1572962.
JD431689 - Sequence 412713 from Patent EP1572962.
JD150445 - Sequence 131469 from Patent EP1572962.
JD150450 - Sequence 131474 from Patent EP1572962.
JD473510 - Sequence 454534 from Patent EP1572962.
JD220537 - Sequence 201561 from Patent EP1572962.
DQ576709 - Homo sapiens piRNA piR-44821, complete sequence.
JD354635 - Sequence 335659 from Patent EP1572962.
JD391212 - Sequence 372236 from Patent EP1572962.
JD338750 - Sequence 319774 from Patent EP1572962.
JD200248 - Sequence 181272 from Patent EP1572962.
JD291365 - Sequence 272389 from Patent EP1572962.
JD071644 - Sequence 52668 from Patent EP1572962.
JD465580 - Sequence 446604 from Patent EP1572962.
JD476260 - Sequence 457284 from Patent EP1572962.
JD443659 - Sequence 424683 from Patent EP1572962.
JD132759 - Sequence 113783 from Patent EP1572962.
JD146053 - Sequence 127077 from Patent EP1572962.
JD246570 - Sequence 227594 from Patent EP1572962.
JD372002 - Sequence 353026 from Patent EP1572962.
JD202784 - Sequence 183808 from Patent EP1572962.
JD387099 - Sequence 368123 from Patent EP1572962.
JD369090 - Sequence 350114 from Patent EP1572962.
JD149555 - Sequence 130579 from Patent EP1572962.
LF337029 - JP 2014500723-A/144532: Polycomb-Associated Non-Coding RNAs.
JD222042 - Sequence 203066 from Patent EP1572962.
JD337837 - Sequence 318861 from Patent EP1572962.
JD195180 - Sequence 176204 from Patent EP1572962.
JD193106 - Sequence 174130 from Patent EP1572962.
JD334644 - Sequence 315668 from Patent EP1572962.
JD405840 - Sequence 386864 from Patent EP1572962.
JD191888 - Sequence 172912 from Patent EP1572962.
LF337030 - JP 2014500723-A/144533: Polycomb-Associated Non-Coding RNAs.
JD119662 - Sequence 100686 from Patent EP1572962.
MA448185 - JP 2018138019-A/20111: Polycomb-Associated Non-Coding RNAs.
MA445885 - JP 2018138019-A/17811: Polycomb-Associated Non-Coding RNAs.
MA445886 - JP 2018138019-A/17812: Polycomb-Associated Non-Coding RNAs.
MA572604 - JP 2018138019-A/144530: Polycomb-Associated Non-Coding RNAs.
MA572605 - JP 2018138019-A/144531: Polycomb-Associated Non-Coding RNAs.
MA572606 - JP 2018138019-A/144532: Polycomb-Associated Non-Coding RNAs.
MA572607 - JP 2018138019-A/144533: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDN6, C8orf55, ENST00000336138.1, ENST00000336138.2, ENST00000336138.3, NM_016647, PSEC0098, Q8NBN2, Q8WUY1, Q9NYI2, THEM6_HUMAN, uc317ulm.1, uc317ulm.2
UCSC ID: ENST00000336138.4_4
RefSeq Accession: NM_016647.3
Protein: Q8WUY1 (aka THEM6_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.