Human Gene TNS2 (ENST00000314250.11_8) from GENCODE V47lift37
  Description: tensin 2, transcript variant 2 (from RefSeq NM_170754.4)
Gencode Transcript: ENST00000314250.11_8
Gencode Gene: ENSG00000111077.18_14
Transcript (Including UTRs)
   Position: hg19 chr12:53,443,849-53,458,163 Size: 14,315 Total Exon Count: 29 Strand: +
Coding Region
   Position: hg19 chr12:53,443,970-53,457,666 Size: 13,697 Coding Exon Count: 29 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:53,443,849-53,458,163)mRNA (may differ from genome)Protein (1409 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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-  Comments and Description Text from UniProtKB
  ID: TENC1_HUMAN
DESCRIPTION: RecName: Full=Tensin-like C1 domain-containing phosphatase; EC=3.1.3.-; AltName: Full=C1 domain-containing phosphatase and tensin homolog; Short=C1-TEN; AltName: Full=Tensin-2;
FUNCTION: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.
SUBUNIT: Interacts with AXL.
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the end of actin stress fibers.
TISSUE SPECIFICITY: Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.
SIMILARITY: Contains 1 C2 tensin-type domain.
SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger.
SIMILARITY: Contains 1 phosphatase tensin-type domain.
SIMILARITY: Contains 1 SH2 domain.
SEQUENCE CAUTION: Sequence=AAI29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI29830.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI31504.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA83027.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH56176.1; Type=Miscellaneous discrepancy; Note=Intron retention;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 138.82 RPKM in Adipose - Subcutaneous
Total median expression: 2957.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.60121-0.435 Picture PostScript Text
3' UTR -176.70497-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR011993 - PH_like_dom
IPR014019 - Phosphatase_tensin-typ
IPR002219 - Prot_Kinase_C-like_PE/DAG-bd
IPR013625 - PTB
IPR006020 - PTyr_interaction_dom
IPR000980 - SH2
IPR014020 - Tensin_phosphatase_C2-dom

Pfam Domains:
PF00017 - SH2 domain
PF08416 - Phosphotyrosine-binding domain
PF10409 - C2 domain of PTEN tumour-suppressor protein

SCOP Domains:
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
52799 - (Phosphotyrosine protein) phosphatases II
55550 - SH2 domain
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2DKQ - NMR MuPIT 2KNO - NMR MuPIT 2L6K - NMR MuPIT 2LOZ - NMR MuPIT 3HQC - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q63HR2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0019900 kinase binding
GO:0046872 metal ion binding

Biological Process:
GO:0001822 kidney development
GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0014850 response to muscle activity
GO:0019725 cellular homeostasis
GO:0032963 collagen metabolic process
GO:0035264 multicellular organism growth
GO:0035556 intracellular signal transduction
GO:0048871 multicellular organismal homeostasis

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030054 cell junction


-  Descriptions from all associated GenBank mRNAs
  AF417490 - Homo sapiens tensin2 mRNA, complete cds.
AF518728 - Homo sapiens C1 domain-containing phosphatase and tensin-like protein splice variant 2 (C1-TEN) mRNA, complete cds; alternatively spliced.
BC131503 - Homo sapiens tensin like C1 domain containing phosphatase (tensin 2), mRNA (cDNA clone IMAGE:40082477), partial cds.
AK172747 - Homo sapiens cDNA FLJ23908 fis, clone ADSU00701.
AB028998 - Homo sapiens KIAA1075 mRNA for KIAA1075 protein.
BC150259 - Homo sapiens tensin like C1 domain containing phosphatase (tensin 2), mRNA (cDNA clone MGC:166823 IMAGE:9007193), complete cds.
AF518729 - Homo sapiens C1 domain-containing phosphatase and tensin-like protein splice variant 1 (C1-TEN) mRNA, complete cds; alternatively spliced.
CR936725 - Homo sapiens mRNA; cDNA DKFZp686D13244 (from clone DKFZp686D13244).
BX647126 - Homo sapiens mRNA; cDNA DKFZp686B19149 (from clone DKFZp686B19149).
AK131320 - Homo sapiens cDNA FLJ16320 fis, clone SPLEN2036702, highly similar to Homo sapiens tensin like C1 domain containing phosphatase (tensin 2) (TENC1), transcript variant 2, mRNA.
BC142668 - Homo sapiens tensin like C1 domain containing phosphatase (tensin 2), mRNA (cDNA clone MGC:164929 IMAGE:40148166), complete cds.
BC142712 - Homo sapiens tensin like C1 domain containing phosphatase (tensin 2), mRNA (cDNA clone MGC:165058 IMAGE:40148847), complete cds.
JD075888 - Sequence 56912 from Patent EP1572962.
JD191323 - Sequence 172347 from Patent EP1572962.
JD393418 - Sequence 374442 from Patent EP1572962.
JD365584 - Sequence 346608 from Patent EP1572962.
AB384104 - Synthetic construct DNA, clone: pF1KSDA1075, Homo sapiens TENC1 gene for tensin-like C1 domain-containing phosphatase, complete cds, without stop codon, in Flexi system.
BC129828 - Homo sapiens tensin like C1 domain containing phosphatase (tensin 2), mRNA (cDNA clone MGC:149324 IMAGE:40114077), complete cds.
BC129829 - Homo sapiens tensin like C1 domain containing phosphatase (tensin 2), mRNA (cDNA clone MGC:149325 IMAGE:40114082), complete cds.
BC110854 - Homo sapiens tensin like C1 domain containing phosphatase (tensin 2), mRNA (cDNA clone IMAGE:6527696), partial cds.
BC054099 - Homo sapiens tensin like C1 domain containing phosphatase (tensin 2), mRNA (cDNA clone IMAGE:5287762), partial cds.
AL137564 - Homo sapiens mRNA; cDNA DKFZp434D098 (from clone DKFZp434D098).
JD192262 - Sequence 173286 from Patent EP1572962.
JD253681 - Sequence 234705 from Patent EP1572962.
JD391031 - Sequence 372055 from Patent EP1572962.
JD393220 - Sequence 374244 from Patent EP1572962.
JD329344 - Sequence 310368 from Patent EP1572962.
JD552039 - Sequence 533063 from Patent EP1572962.
JD178581 - Sequence 159605 from Patent EP1572962.
JD347140 - Sequence 328164 from Patent EP1572962.
JD454549 - Sequence 435573 from Patent EP1572962.
JD111107 - Sequence 92131 from Patent EP1572962.
JD084717 - Sequence 65741 from Patent EP1572962.
JD355448 - Sequence 336472 from Patent EP1572962.
JD474321 - Sequence 455345 from Patent EP1572962.
JD446050 - Sequence 427074 from Patent EP1572962.
JD068986 - Sequence 50010 from Patent EP1572962.
JD084579 - Sequence 65603 from Patent EP1572962.
JD200037 - Sequence 181061 from Patent EP1572962.
JD207335 - Sequence 188359 from Patent EP1572962.
JD498643 - Sequence 479667 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2VDF2, A2VDF3, A2VDI8, A5PKY4, ENST00000314250.1, ENST00000314250.10, ENST00000314250.2, ENST00000314250.3, ENST00000314250.4, ENST00000314250.5, ENST00000314250.6, ENST00000314250.7, ENST00000314250.8, ENST00000314250.9, KIAA1075, NM_170754, Q2NL80, Q63HR2, Q76MW6, Q7Z5T9, Q8NFF9, Q8NFG0, Q96P25, Q9NT29, Q9UPS7, TENC1, TENS2_HUMAN, uc317pot.1, uc317pot.2
UCSC ID: ENST00000314250.11_8
RefSeq Accession: NM_170754.4
Protein: Q63HR2 (aka TENC1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.