Human Gene TAS2R30 (ENST00000539585.1_6) from GENCODE V47lift37

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Human Gene TAS2R30 (ENST00000539585.1_6) from GENCODE V47lift37

Description: taste 2 receptor member 30 (from RefSeq NM_001097643.2)
Gencode Transcript: ENST00000539585.1_6
Gencode Gene: ENSG00000256188.3_8
Transcript (Including UTRs)
Position: hg19 chr12:11,285,557-11,287,243 Size: 1,687 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr12:11,285,884-11,286,843 Size: 960 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	Gene Alleles	RNA-Seq Expression
RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:11,285,557-11,287,243)			mRNA (may differ from genome)		Protein (319 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q50KG7_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 2; Flags: Fragment; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor T2R family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.06 RPKM in Brain - Cerebellum Total median expression: 0.70 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-82.00	400	-0.205	Picture	PostScript	Text
3' UTR	-58.30	327	-0.178	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007960 - TAS2_rcpt

Pfam Domains:
PF05296 - Taste receptor protein (TAS2R)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q50KG7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0050896 response to stimulus GO:0050909 sensory perception of taste Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	BC117421 - Homo sapiens taste receptor, type 2, member 44, mRNA (cDNA clone MGC:151030 IMAGE:40125972), complete cds. LP895864 - Sequence 728 from Patent EP3253886. BC156865 - Synthetic construct Homo sapiens clone IMAGE:100062591, MGC:190578 taste receptor, type 2, member 47 (TAS2R47) mRNA, encodes complete protein.

Other Names for This Gene


	Alternate Gene Symbols: Hosa(Biaka)-T2R47 , NM_001097643, Q50KG7, Q50KG7_HUMAN, uc324rlm.1, uc324rlm.2 UCSC ID: ENST00000539585.1_6 RefSeq Accession: NM_001097643.2 Protein: Q50KG7

Gene Model Information


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Methods, Credits, and Use Restrictions


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