Human Gene TAPBPL (ENST00000266556.8_4) from GENCODE V47lift37
  Description: TAP binding protein like, transcript variant 6 (from RefSeq NR_147129.2)
Gencode Transcript: ENST00000266556.8_4
Gencode Gene: ENSG00000139192.12_8
Transcript (Including UTRs)
   Position: hg19 chr12:6,561,208-6,571,482 Size: 10,275 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr12:6,561,415-6,571,315 Size: 9,901 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:6,561,208-6,571,482)mRNA (may differ from genome)Protein (468 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TPSNR_HUMAN
DESCRIPTION: RecName: Full=Tapasin-related protein; Short=TAPASIN-R; AltName: Full=TAP-binding protein-like; AltName: Full=TAP-binding protein-related protein; Short=TAPBP-R; AltName: Full=Tapasin-like; Flags: Precursor;
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Probable). Endoplasmic reticulum membrane; Single-pass type I membrane protein (Probable). Microsome membrane; Single- pass type I membrane protein (Probable). Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface.
SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.23 RPKM in Thyroid
Total median expression: 364.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.90207-0.367 Picture PostScript Text
3' UTR -26.10167-0.156 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003006 - Ig/MHC_CS
IPR003597 - Ig_C1-set
IPR003599 - Ig_sub
IPR013106 - Ig_V-set
IPR008056 - Tapasin

Pfam Domains:
PF07654 - Immunoglobulin C1-set domain
PF07686 - Immunoglobulin V-set domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q9BX59
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0044877 macromolecular complex binding

Biological Process:
GO:0002376 immune system process
GO:0002590 negative regulation of antigen processing and presentation of peptide antigen via MHC class I

Cellular Component:
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031090 organelle membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  LF207398 - JP 2014500723-A/14901: Polycomb-Associated Non-Coding RNAs.
MA442975 - JP 2018138019-A/14901: Polycomb-Associated Non-Coding RNAs.
LF207400 - JP 2014500723-A/14903: Polycomb-Associated Non-Coding RNAs.
LF365926 - JP 2014500723-A/173429: Polycomb-Associated Non-Coding RNAs.
BC015017 - Homo sapiens TAP binding protein-like, mRNA (cDNA clone MGC:8836 IMAGE:3916213), complete cds.
AK223163 - Homo sapiens mRNA for TAP binding protein-like variant, clone: LNG04547.
JD434043 - Sequence 415067 from Patent EP1572962.
JD302474 - Sequence 283498 from Patent EP1572962.
JD080019 - Sequence 61043 from Patent EP1572962.
JD256429 - Sequence 237453 from Patent EP1572962.
AK001005 - Homo sapiens cDNA FLJ10143 fis, clone HEMBA1003281, weakly similar to POLIOVIRUS RECEPTOR PRECURSOR.
AK222956 - Homo sapiens mRNA for TAP binding protein-like variant, clone: HSI00801.
AK002056 - Homo sapiens cDNA FLJ11194 fis, clone PLACE1007632, weakly similar to POLIOVIRUS RECEPTOR PRECURSOR.
JD036982 - Sequence 18006 from Patent EP1572962.
JD130017 - Sequence 111041 from Patent EP1572962.
JD341846 - Sequence 322870 from Patent EP1572962.
AK098035 - Homo sapiens cDNA FLJ40716 fis, clone THYMU2027975.
JD177027 - Sequence 158051 from Patent EP1572962.
HQ258015 - Synthetic construct Homo sapiens clone IMAGE:100072324 TAP binding protein-like (TAPBPL) gene, encodes complete protein.
KJ904791 - Synthetic construct Homo sapiens clone ccsbBroadEn_14185 TAPBPL gene, encodes complete protein.
JD334697 - Sequence 315721 from Patent EP1572962.
JD293897 - Sequence 274921 from Patent EP1572962.
MA601503 - JP 2018138019-A/173429: Polycomb-Associated Non-Coding RNAs.
MA442977 - JP 2018138019-A/14903: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000266556.1, ENST00000266556.2, ENST00000266556.3, ENST00000266556.4, ENST00000266556.5, ENST00000266556.6, ENST00000266556.7, NR_147129, Q9BX59, Q9NWB8, TPSNR_HUMAN, uc317ihn.1, uc317ihn.2
UCSC ID: ENST00000266556.8_4
RefSeq Accession: NM_018009.5
Protein: Q9BX59 (aka TPSNR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.