Human Gene TAGLN2 (ENST00000368097.9_7) from GENCODE V47lift37
  Description: transgelin 2, transcript variant 2 (from RefSeq NM_003564.3)
Gencode Transcript: ENST00000368097.9_7
Gencode Gene: ENSG00000158710.15_11
Transcript (Including UTRs)
   Position: hg19 chr1:159,887,901-159,895,297 Size: 7,397 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr1:159,888,590-159,890,299 Size: 1,710 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:159,887,901-159,895,297)mRNA (may differ from genome)Protein (199 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TAGL2_HUMAN
DESCRIPTION: RecName: Full=Transgelin-2; AltName: Full=Epididymis tissue protein Li 7e; AltName: Full=SM22-alpha homolog;
INTERACTION: P60709:ACTB; NbExp=3; IntAct=EBI-1056740, EBI-353944;
TISSUE SPECIFICITY: Expressed in epididymis (at protein level).
SIMILARITY: Belongs to the calponin family.
SIMILARITY: Contains 1 calponin-like repeat.
SIMILARITY: Contains 1 CH (calponin-homology) domain.
SEQUENCE CAUTION: Sequence=AAG01993.1; Type=Erroneous initiation; Sequence=BAA04802.2; Type=Erroneous initiation; Sequence=CAI14604.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 413.61 RPKM in Whole Blood
Total median expression: 5588.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.1086-0.187 Picture PostScript Text
3' UTR -245.00689-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000557 - Calponin_repeat
IPR001715 - CH-domain
IPR003096 - SM22_calponin
IPR001061 - TAGLN

Pfam Domains:
PF00307 - Calponin homology (CH) domain
PF00402 - Calponin family repeat

SCOP Domains:
47576 - Calponin-homology domain, CH-domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1WYM - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P37802
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0045296 cadherin binding

Biological Process:
GO:0002576 platelet degranulation
GO:0030855 epithelial cell differentiation

Cellular Component:
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0031982 vesicle
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF205472 - JP 2014500723-A/12975: Polycomb-Associated Non-Coding RNAs.
AY007127 - Homo sapiens clone CDABP0035 mRNA sequence.
BC009357 - Homo sapiens transgelin 2, mRNA (cDNA clone MGC:15279 IMAGE:4301018), complete cds.
D21261 - Homo sapiens KIAA0120 mRNA.
GU727636 - Homo sapiens epididymis tissue sperm binding protein Li 7e mRNA, complete cds.
LF320833 - JP 2014500723-A/128336: Polycomb-Associated Non-Coding RNAs.
JD119723 - Sequence 100747 from Patent EP1572962.
JD218965 - Sequence 199989 from Patent EP1572962.
JD045705 - Sequence 26729 from Patent EP1572962.
JD410756 - Sequence 391780 from Patent EP1572962.
JD497615 - Sequence 478639 from Patent EP1572962.
JD162835 - Sequence 143859 from Patent EP1572962.
JD498053 - Sequence 479077 from Patent EP1572962.
LF320832 - JP 2014500723-A/128335: Polycomb-Associated Non-Coding RNAs.
JD392030 - Sequence 373054 from Patent EP1572962.
JD071288 - Sequence 52312 from Patent EP1572962.
LF320831 - JP 2014500723-A/128334: Polycomb-Associated Non-Coding RNAs.
AK291562 - Homo sapiens cDNA FLJ76411 complete cds, highly similar to Homo sapiens transgelin 2 (TAGLN2), mRNA.
JD525319 - Sequence 506343 from Patent EP1572962.
JD465807 - Sequence 446831 from Patent EP1572962.
JD422993 - Sequence 404017 from Patent EP1572962.
AJ844624 - Homo sapiens mRNA for transgelin 2 (TAGLN2 gene), 3'UTR.
JD180453 - Sequence 161477 from Patent EP1572962.
JD206085 - Sequence 187109 from Patent EP1572962.
JD481940 - Sequence 462964 from Patent EP1572962.
JD357896 - Sequence 338920 from Patent EP1572962.
DL491942 - Novel nucleic acids.
DL490501 - Novel nucleic acids.
JD500084 - Sequence 481108 from Patent EP1572962.
JD532673 - Sequence 513697 from Patent EP1572962.
JD401176 - Sequence 382200 from Patent EP1572962.
JD157705 - Sequence 138729 from Patent EP1572962.
LF320830 - JP 2014500723-A/128333: Polycomb-Associated Non-Coding RNAs.
BC002616 - Homo sapiens transgelin 2, mRNA (cDNA clone MGC:2989 IMAGE:3143116), complete cds.
JD266411 - Sequence 247435 from Patent EP1572962.
JD524343 - Sequence 505367 from Patent EP1572962.
JD386997 - Sequence 368021 from Patent EP1572962.
JD252290 - Sequence 233314 from Patent EP1572962.
LF320829 - JP 2014500723-A/128332: Polycomb-Associated Non-Coding RNAs.
JD076173 - Sequence 57197 from Patent EP1572962.
JD057183 - Sequence 38207 from Patent EP1572962.
JD100440 - Sequence 81464 from Patent EP1572962.
CR542126 - Homo sapiens full open reading frame cDNA clone RZPDo834B0923D for gene TAGLN2, transgelin 2; complete cds, incl. stopcodon.
GQ891348 - Homo sapiens clone HEL-S-119d epididymis secretory sperm binding protein mRNA, complete cds.
KJ897841 - Synthetic construct Homo sapiens clone ccsbBroadEn_07235 TAGLN2 gene, encodes complete protein.
KJ897842 - Synthetic construct Homo sapiens clone ccsbBroadEn_07236 TAGLN2 gene, encodes complete protein.
AB383755 - Synthetic construct DNA, clone: pF1KSDA0120, Homo sapiens TAGLN2 gene for transgelin-2, complete cds, without stop codon, in Flexi system.
DQ891915 - Synthetic construct clone IMAGE:100004545; FLH181381.01X; RZPDo839C10136D transgelin 2 (TAGLN2) gene, encodes complete protein.
DQ895100 - Synthetic construct Homo sapiens clone IMAGE:100009560; FLH181377.01L; RZPDo839C10135D transgelin 2 (TAGLN2) gene, encodes complete protein.
CR542136 - Homo sapiens full open reading frame cDNA clone RZPDo834E0123D for gene TAGLN2, transgelin 2; complete cds, without stopcodon.
LF320828 - JP 2014500723-A/128331: Polycomb-Associated Non-Coding RNAs.
CU679319 - Synthetic construct Homo sapiens gateway clone IMAGE:100017574 5' read TAGLN2 mRNA.
AK298654 - Homo sapiens cDNA FLJ57759 complete cds, moderately similar to Transgelin-2.
LF320825 - JP 2014500723-A/128328: Polycomb-Associated Non-Coding RNAs.
JD375807 - Sequence 356831 from Patent EP1572962.
JD515887 - Sequence 496911 from Patent EP1572962.
MA441049 - JP 2018138019-A/12975: Polycomb-Associated Non-Coding RNAs.
MA556410 - JP 2018138019-A/128336: Polycomb-Associated Non-Coding RNAs.
MA556409 - JP 2018138019-A/128335: Polycomb-Associated Non-Coding RNAs.
MA556408 - JP 2018138019-A/128334: Polycomb-Associated Non-Coding RNAs.
MA556407 - JP 2018138019-A/128333: Polycomb-Associated Non-Coding RNAs.
MA556406 - JP 2018138019-A/128332: Polycomb-Associated Non-Coding RNAs.
MA556405 - JP 2018138019-A/128331: Polycomb-Associated Non-Coding RNAs.
MA556402 - JP 2018138019-A/128328: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P37802 (Reactome details) participates in the following event(s):

R-HSA-482772 Release of platelet cytosolic components
R-HSA-114608 Platelet degranulation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: CDABP0035, E9KL39, ENST00000368097.1, ENST00000368097.2, ENST00000368097.3, ENST00000368097.4, ENST00000368097.5, ENST00000368097.6, ENST00000368097.7, ENST00000368097.8, KIAA0120, NM_003564, P37802, Q5JRQ6, Q5JRQ7, Q6FGI1, Q9BUH5, Q9H4P0, TAGL2_HUMAN, uc318glw.1, uc318glw.2
UCSC ID: ENST00000368097.9_7
RefSeq Accession: NM_003564.3
Protein: P37802 (aka TAGL2_HUMAN or TAG2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.