ID:SPTB2_HUMAN DESCRIPTION: RecName: Full=Spectrin beta chain, non-erythrocytic 1; AltName: Full=Beta-II spectrin; AltName: Full=Fodrin beta chain; AltName: Full=Spectrin, non-erythroid beta chain 1; FUNCTION: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. SUBUNIT: Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers. The short form cannot bind to the axonal protein fodaxin. Interacts with ANK2. INTERACTION: Q9NRI5:DISC1; NbExp=3; IntAct=EBI-351561, EBI-529989; P02549:SPTA1; NbExp=3; IntAct=EBI-351561, EBI-375617; Q13813:SPTAN1; NbExp=7; IntAct=EBI-351561, EBI-351450; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, M line (By similarity). Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes (By similarity). SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). TISSUE SPECIFICITY: Isoform 2 is present in brain, lung and kidney (at protein level). PTM: Isoform 2 is phosphorylated on Ser-8 and Ser-10 (By similarity). SIMILARITY: Belongs to the spectrin family. SIMILARITY: Contains 2 CH (calponin-homology) domains. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 17 spectrin repeats. SEQUENCE CAUTION: Sequence=BAD92985.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01082
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0000281 mitotic cytokinesis GO:0006888 ER to Golgi vesicle-mediated transport GO:0007009 plasma membrane organization GO:0007010 cytoskeleton organization GO:0007182 common-partner SMAD protein phosphorylation GO:0007411 axon guidance GO:0043001 Golgi to plasma membrane protein transport GO:0051693 actin filament capping GO:0060390 regulation of SMAD protein import into nucleus GO:0071709 membrane assembly GO:0072659 protein localization to plasma membrane GO:1900042 positive regulation of interleukin-2 secretion GO:1903076 regulation of protein localization to plasma membrane GO:1903078 positive regulation of protein localization to plasma membrane
BioCarta from NCI Cancer Genome Anatomy Project h_PDZsPathway - Synaptic Proteins at the Synaptic Junction
Reactome (by CSHL, EBI, and GO)
Protein Q01082 (Reactome details) participates in the following event(s):
R-HSA-451403 Interaction of nephrin with adherens junction-associated proteins R-HSA-391868 Dephosphorylation of NCAM1 bound pFyn R-NUL-420388 Dephosphorylation of NCAM1 bound pFyn R-HSA-391865 Recruitment of FAK to NCAM1:Fyn in lipid rafts R-HSA-391871 Autophosphorylation of NCAM1 bound Fyn R-HSA-392751 L1 linked to actin cytoskeleton by ankyrin R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-NUL-420398 Autophosphorylation of NCAM1 bound Fyn R-HSA-391866 Phosphorylation of FAK by Src kinase R-HSA-392051 Recruitment of Grb2 to pFAK:NCAM1 R-HSA-392053 SOS binds Grb2 bound to pFAK:NCAM1 R-HSA-373739 Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-392054 NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange R-HSA-373753 Nephrin family interactions R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-1500931 Cell-Cell communication R-HSA-445095 Interaction between L1 and Ankyrins R-HSA-6807878 COPI-mediated anterograde transport R-HSA-422475 Axon guidance R-HSA-373760 L1CAM interactions R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-1266738 Developmental Biology R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-597592 Post-translational protein modification R-HSA-5683057 MAPK family signaling cascades R-HSA-392499 Metabolism of proteins R-HSA-162582 Signal Transduction
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
