ID:SOS1_HUMAN DESCRIPTION: RecName: Full=Son of sevenless homolog 1; Short=SOS-1; FUNCTION: Promotes the exchange of Ras-bound GDP by GTP. SUBUNIT: Interacts with GRB2. Forms a complex with phosphorylated MUC1 and GRB2 (via its SH3 domains). Interacts with phosphorylated LAT2. Interacts with NCK1 and NCK2. INTERACTION: P46108:CRK; NbExp=2; IntAct=EBI-297487, EBI-886; P62993:GRB2; NbExp=9; IntAct=EBI-297487, EBI-401755; P01112:HRAS; NbExp=6; IntAct=EBI-297487, EBI-350145; P16333:NCK1; NbExp=5; IntAct=EBI-297487, EBI-389883; Q9UKS6:PACSIN3; NbExp=2; IntAct=EBI-297487, EBI-77926; P27986:PIK3R1; NbExp=2; IntAct=EBI-297487, EBI-79464; P19174:PLCG1; NbExp=2; IntAct=EBI-297487, EBI-79387; Q9Y5X1:SNX9; NbExp=2; IntAct=EBI-297487, EBI-77848; TISSUE SPECIFICITY: Expressed in gingival tissues. DISEASE: Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common. DISEASE: Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 N-terminal Ras-GEF domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 Ras-GEF domain. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SOS1"; WEB RESOURCE: Name=Wikipedia; Note=Son of sevenless entry; URL="http://en.wikipedia.org/wiki/Son_of_Sevenless";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q07889
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_insulinPathway - Insulin Signaling Pathway h_pyk2Pathway - Links between Pyk2 and Map Kinases h_trkaPathway - Trka Receptor Signaling Pathway h_egfPathway - EGF Signaling Pathway h_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis h_crebPathway - Transcription factor CREB and its extracellular signals h_tcrPathway - T Cell Receptor Signaling Pathway h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation h_il2Pathway - IL 2 signaling pathway h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation h_il3Pathway - IL 3 signaling pathway h_integrinPathway - Integrin Signaling Pathway h_metPathway - Signaling of Hepatocyte Growth Factor Receptor h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology h_tffPathway - Trefoil Factors Initiate Mucosal Healing h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_il6Pathway - IL 6 signaling pathway h_bcrPathway - BCR Signaling Pathway h_epoPathway - EPO Signaling Pathway h_erkPathway - Erk1/Erk2 Mapk Signaling pathway h_ghPathway - Growth Hormone Signaling Pathway h_ngfPathway - Nerve growth factor pathway (NGF) h_pdgfPathway - PDGF Signaling Pathway h_spryPathway - Sprouty regulation of tyrosine kinase signals h_HBxPathway - Calcium Signaling by HBx of Hepatitis B virus h_TPOPathway - TPO Signaling Pathway h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_igf1Pathway - IGF-1 Signaling Pathway
Reactome (by CSHL, EBI, and GO)
Protein Q07889 (Reactome details) participates in the following event(s):
R-HSA-109813 GRB2-1 binds SOS1 R-HSA-210974 Interaction of SOS-1 to Tie2 bound Grb2 R-HSA-354165 Interaction of SOS with GRB2 bound to FADK1 R-HSA-392053 SOS binds Grb2 bound to pFAK:NCAM1 R-HSA-8851859 Activated MET binds RANBP9 and SOS1 R-HSA-74736 GRB2-1:SOS1 binds p-IRS1,p-IRS2 R-HSA-74746 GRB2-1:SOS1 binds p-Y427-SHC1 R-HSA-177936 GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR R-HSA-177943 GRB2:SOS1 complex binds to EGF:EGFR complex R-HSA-186826 Grb2/Sos1 complex binds to the active receptor R-HSA-205286 GRB2:SOS interacts with p-KIT R-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1 R-HSA-1225950 Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants R-HSA-1225961 Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex R-HSA-1250380 Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers R-HSA-1250486 Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers R-HSA-1250488 GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer R-HSA-1306969 GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers R-HSA-2179415 GRB2:SOS1 binds to HBEGF:p-Y-EGFR R-HSA-2730844 Interaction of GRB2:SOS complex with p-SHC1 R-HSA-5637770 Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII R-HSA-5637798 Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1 R-HSA-5654416 Activated FGFR3:pFRS binds GRB2:SOS1 R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1 R-HSA-5654586 Activated FGFR1:p-FRS binds GRB2:SOS1 R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1 R-HSA-5654615 Activated FGFR2:pFRS binds GRB2:SOS1 R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1 R-HSA-5654664 Activated FGFR4:p-FRS binds GRB2:SOS1 R-HSA-5655233 Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 R-HSA-5655266 Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 R-HSA-5655295 Activated FGFR3 mutants:p-FRS2 binds GRB2-SOS1 R-HSA-5655348 Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 R-HSA-5685366 GRB2-1:SOS1 binds p-Y-SHC R-HSA-5686073 GRB2-1:SOS1 binds p-3Y-SHC1 R-HSA-8851804 Activated MET recruits GRB2-1:SOS1 R-HSA-8851900 SHC1-2 bound to MET recruits GRB2:SOS1 R-HSA-8853314 Activated FGFR3 fusions:p-FRS2 bind GRB2-SOS1 R-HSA-8853734 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 R-HSA-8854899 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 R-HSA-9028328 SHC1 bound to activated NTRK2 recruits GRB2:SOS1 R-HSA-983703 p-6Y-SYK phosphorylates BLNK (SLP65) R-HSA-428515 Recruitment of SOS to plasma membrane R-HSA-5686074 GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates R-HSA-5686315 GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates R-HSA-109822 MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 R-HSA-109823 MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 R-HSA-2396599 Recruitment of GRB2:SOS to p-5Y-LAT R-HSA-2730837 Recruitment of GRB2:SOS to p-10Y-NTAL R-HSA-210977 Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) R-HSA-8851877 RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET R-HSA-194913 GEFs activate Rho GTPase:GDP R-HSA-419166 GEFs activate RhoA,B,C R-HSA-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor R-HSA-109807 GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS R-HSA-109817 GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS R-HSA-177938 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) R-HSA-177945 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) R-HSA-186834 Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) R-HSA-205244 Recruitment of CBL to KIT R-HSA-1433471 Activation of RAS by p-KIT bound SOS1 R-HSA-1225957 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) R-HSA-1225951 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) R-HSA-1250383 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 R-HSA-1250463 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers R-HSA-1250498 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. R-HSA-1306972 RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers R-HSA-2179407 SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) R-HSA-2396561 Recruitment of GADS:SLP-76 to p-5Y-LAT R-HSA-2730848 Recruitment of GAB2 to PM and FCERI by binding to GRB2 R-HSA-5637806 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) R-HSA-5637808 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) R-HSA-5654392 Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5654413 Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5654663 Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5655277 Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5655326 Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5655347 Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5655241 Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-5686071 GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS R-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS R-HSA-8851827 RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 R-HSA-8851899 RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET R-HSA-8853307 FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange R-HSA-9026891 NTRK2 activates RAS signaling through SHC1 R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange R-HSA-392054 NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras R-HSA-428535 Activation of RAC1 by SOS R-HSA-2424485 Release of p-PLCG1 R-HSA-2424481 Recruitment of VAV and BTK to p-SLP-76 R-HSA-2730892 Recruitment of VAV to p-SLP-76 R-HSA-2396594 Phosphorylation of SLP-76 by p-SYK R-HSA-2730851 Phosphorylation of SLP-76 by p-SYK R-HSA-2396606 Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT R-HSA-2424477 SOS mediated nucleotide exchange of RAS (SHC) R-HSA-2730842 PI3K associates with phosphorylated GAB2 R-HSA-2730860 Phosphorylation of GAB2 by SYK/FYN R-HSA-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate R-HSA-2424487 Phosphorylation of PLC-gamma by p-BTK/p-SYK R-HSA-2424484 Phosphorylation of BTK by p-SYK R-HSA-2424486 Phosphorylation and activation of VAV2/VAV3 by SYK R-HSA-2730888 Phosphorylation of PLC-gamma R-HSA-2730858 Autophosphorylation of BTK/ITK R-HSA-2730840 Activation of RAC1 by VAV R-HSA-2730841 Phosphorylation and activation of VAV R-HSA-2730885 Recruitment of TEC kinases to p-SLP-76 R-HSA-2730833 Phosphorylation of TEC kinases by p-SYK R-HSA-2730889 Recruitment of PAK to the membrane by binding active RAC1 R-HSA-2730856 Autophosphorylation of PAK R-HSA-2424476 Activation of RAC1 by VAV2/3 R-HSA-2730847 Hydrolysis of PIP2 by PLCG R-HSA-2730870 Phosphorylation of PIP2 to PIP3 by PI3K R-HSA-74751 Insulin receptor signalling cascade R-HSA-179812 GRB2 events in EGFR signaling R-HSA-210993 Tie2 Signaling R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-8851805 MET activates RAS signaling R-HSA-112412 SOS-mediated signalling R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-1433557 Signaling by SCF-KIT R-HSA-912526 Interleukin receptor SHC signaling R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-2179392 EGFR Transactivation by Gastrin R-HSA-2871796 FCERI mediated MAPK activation R-HSA-5637810 Constitutive Signaling by EGFRvIII R-HSA-5654699 SHC-mediated cascade:FGFR2 R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654719 SHC-mediated cascade:FGFR4 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654688 SHC-mediated cascade:FGFR1 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654704 SHC-mediated cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-8853338 Signaling by FGFR3 point mutants in cancer R-HSA-5655291 Signaling by FGFR4 in disease R-HSA-167044 Signalling to RAS R-HSA-2428933 SHC-related events triggered by IGF1R R-HSA-8853334 Signaling by FGFR3 fusions in cancer R-HSA-8853659 RET signaling R-HSA-9026519 Activated NTRK2 signals through RAS R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-428540 Activation of RAC1 R-HSA-8983432 Interleukin-15 signaling R-HSA-74752 Signaling by Insulin receptor R-HSA-177929 Signaling by EGFR R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-354192 Integrin alphaIIb beta3 signaling R-HSA-422475 Axon guidance R-HSA-6806834 Signaling by MET R-HSA-74749 Signal attenuation R-HSA-2424491 DAP12 signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-112399 IRS-mediated signalling R-HSA-186797 Signaling by PDGF R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-451927 Interleukin-2 family signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-1236394 Signaling by ERBB4 R-HSA-1227986 Signaling by ERBB2 R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-5637812 Signaling by EGFRvIII in Cancer R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-1226099 Signaling by FGFR in disease R-HSA-5655332 Signaling by FGFR3 in disease R-HSA-187687 Signalling to ERKs R-HSA-2428924 IGF1R signaling cascade R-HSA-9006115 Signaling by NTRK2 (TRKB) R-HSA-983705 Signaling by the B Cell Receptor (BCR) R-HSA-376176 Signaling by ROBO receptors R-HSA-194840 Rho GTPase cycle R-HSA-416482 G alpha (12/13) signalling events R-HSA-193648 NRAGE signals death through JNK R-HSA-109582 Hemostasis R-HSA-76009 Platelet Aggregation (Plug Formation) R-HSA-9006921 Integrin signaling R-HSA-1266738 Developmental Biology R-HSA-1433559 Regulation of KIT signaling R-HSA-2172127 DAP12 interactions R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-162582 Signal Transduction R-HSA-449147 Signaling by Interleukins R-HSA-1643713 Signaling by EGFR in Cancer R-HSA-416476 G alpha (q) signalling events R-HSA-168249 Innate Immune System R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5663202 Diseases of signal transduction R-HSA-187037 Signaling by NTRK1 (TRKA) R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-166520 Signaling by NTRKs R-HSA-5673001 RAF/MAP kinase cascade R-HSA-1280218 Adaptive Immune System R-HSA-194315 Signaling by Rho GTPases R-HSA-388396 GPCR downstream signalling R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System R-HSA-190236 Signaling by FGFR R-HSA-1643685 Disease R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-372790 Signaling by GPCR R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-5683057 MAPK family signaling cascades R-HSA-73887 Death Receptor Signalling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
