Human Gene SORBS2 (ENST00000695409.1_6) from GENCODE V47lift37
  Description: sorbin and SH3 domain containing 2, transcript variant 42 (from RefSeq NM_001395207.1)
Gencode Transcript: ENST00000695409.1_6
Gencode Gene: ENSG00000154556.20_20
Transcript (Including UTRs)
   Position: hg19 chr4:186,506,677-186,733,348 Size: 226,672 Total Exon Count: 27 Strand: -
Coding Region
   Position: hg19 chr4:186,508,781-186,611,725 Size: 102,945 Coding Exon Count: 24 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:186,506,677-186,733,348)mRNA (may differ from genome)Protein (1300 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SORBS2
Diseases sorted by gene-association score: facioscapulohumeral muscular dystrophy 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -264.90767-0.345 Picture PostScript Text
3' UTR -544.802104-0.259 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  AK225812 - Homo sapiens mRNA for Arg/Abl-interacting protein 2 isoform 1 variant, clone: FCC129E07.
BC011883 - Homo sapiens sorbin and SH3 domain containing 2, mRNA (cDNA clone MGC:20120 IMAGE:3677070), complete cds.
AK225327 - Homo sapiens mRNA for Arg/Abl-interacting protein 2 isoform 1 variant, clone: HEP12372.
AK293400 - Homo sapiens cDNA FLJ56051 complete cds, highly similar to Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 1, mRNA.
AK056628 - Homo sapiens cDNA FLJ32066 fis, clone OCBBF1000091, highly similar to Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 2, mRNA.
AB018320 - Homo sapiens KIAA0777 mRNA for KIAA0777 protein.
AF049884 - Homo sapiens Arg/Abl-interacting protein ArgBP2a (ArgBP2a) mRNA, complete cds.
AF049885 - Homo sapiens Arg/Abl-interacting protein ArgBP2b (ArgBP2b) mRNA, partial cds.
AK295742 - Homo sapiens cDNA FLJ55213 complete cds, highly similar to Rattus norvegicus Arg/Abl-interacting protein ArgBP2 (Argbp2), mRNA.
AK304653 - Homo sapiens cDNA FLJ54581 complete cds, highly similar to Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 1, mRNA.
AK296461 - Homo sapiens cDNA FLJ53348 complete cds, highly similar to Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 2, mRNA.
EU832635 - Synthetic construct Homo sapiens clone HAIB:100067664; DKFZo008D0731 sorbin and SH3 domain containing 2 protein (SORBS2) gene, encodes complete protein.
EU832711 - Synthetic construct Homo sapiens clone HAIB:100067740; DKFZo004D0732 sorbin and SH3 domain containing 2 protein (SORBS2) gene, encodes complete protein.
AM392889 - Synthetic construct Homo sapiens clone IMAGE:100002930 for hypothetical protein (SORBS2 gene).
AM393034 - Synthetic construct Homo sapiens clone IMAGE:100002931 for hypothetical protein (SORBS2 gene).
AM393056 - Synthetic construct Homo sapiens clone IMAGE:100002927 for hypothetical protein (SORBS2 gene).
AM393172 - Synthetic construct Homo sapiens clone IMAGE:100002932 for hypothetical protein (SORBS2 gene).
AM393267 - Synthetic construct Homo sapiens clone IMAGE:100002920 for hypothetical protein (SORBS2 gene).
AM393367 - Synthetic construct Homo sapiens clone IMAGE:100002925 for hypothetical protein (SORBS2 gene).
AM393650 - Synthetic construct Homo sapiens clone IMAGE:100002933 for hypothetical protein (SORBS2 gene).
AM393834 - Synthetic construct Homo sapiens clone IMAGE:100002928 for hypothetical protein (SORBS2 gene).
AM392656 - Synthetic construct Homo sapiens clone IMAGE:100002924 for hypothetical protein (SORBS2 gene).
AM392793 - Synthetic construct Homo sapiens clone IMAGE:100002921 for hypothetical protein (SORBS2 gene).
AM392850 - Synthetic construct Homo sapiens clone IMAGE:100002923 for hypothetical protein (SORBS2 gene).
AM392855 - Synthetic construct Homo sapiens clone IMAGE:100002936 for hypothetical protein (SORBS2 gene).
AM392933 - Synthetic construct Homo sapiens clone IMAGE:100002929 for hypothetical protein (SORBS2 gene).
AM393012 - Synthetic construct Homo sapiens clone IMAGE:100002935 for hypothetical protein (SORBS2 gene).
AM393636 - Synthetic construct Homo sapiens clone IMAGE:100002922 for hypothetical protein (SORBS2 gene).
AM393127 - Synthetic construct Homo sapiens clone IMAGE:100002926 for hypothetical protein (SORBS2 gene).
AM393190 - Synthetic construct Homo sapiens clone IMAGE:100002934 for hypothetical protein (SORBS2 gene).
AB384525 - Synthetic construct DNA, clone: pF1KA0777, Homo sapiens SORBS2 gene for sorbin and SH3 domain-containing protein 2, complete cds, without stop codon, in Flexi system.
AM392558 - Synthetic construct Homo sapiens clone IMAGE:100002690 for hypothetical protein (SORBS2 gene).
AM392985 - Synthetic construct Homo sapiens clone IMAGE:100002685 for hypothetical protein (SORBS2 gene).
AM393706 - Synthetic construct Homo sapiens clone IMAGE:100002681 for hypothetical protein (SORBS2 gene).
AM392618 - Synthetic construct Homo sapiens clone IMAGE:100002684 for hypothetical protein (SORBS2 gene).
AM392766 - Synthetic construct Homo sapiens clone IMAGE:100002686 for hypothetical protein (SORBS2 gene).
AM393014 - Synthetic construct Homo sapiens clone IMAGE:100002688 for hypothetical protein (SORBS2 gene).
AM393054 - Synthetic construct Homo sapiens clone IMAGE:100002683 for hypothetical protein (SORBS2 gene).
AM393221 - Synthetic construct Homo sapiens clone IMAGE:100002687 for hypothetical protein (SORBS2 gene).
AM393501 - Synthetic construct Homo sapiens clone IMAGE:100002689 for hypothetical protein (SORBS2 gene).
AM393693 - Synthetic construct Homo sapiens clone IMAGE:100002682 for hypothetical protein (SORBS2 gene).
BC035329 - Homo sapiens sorbin and SH3 domain containing 2, mRNA (cDNA clone IMAGE:5194874).
AK094603 - Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590.
JD302779 - Sequence 283803 from Patent EP1572962.
JD207840 - Sequence 188864 from Patent EP1572962.
JD162194 - Sequence 143218 from Patent EP1572962.
JD345504 - Sequence 326528 from Patent EP1572962.
JD354424 - Sequence 335448 from Patent EP1572962.
JD049041 - Sequence 30065 from Patent EP1572962.
JD363366 - Sequence 344390 from Patent EP1572962.
JD409901 - Sequence 390925 from Patent EP1572962.
JD409902 - Sequence 390926 from Patent EP1572962.
AK056758 - Homo sapiens cDNA FLJ32196 fis, clone PLACE6002668, highly similar to Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 1, mRNA.
EF139852 - Homo sapiens clone 2-3 sorbin and SH3 domain containing 2 splice variant (SORBS2) mRNA, partial sequence; alternatively spliced.
AK000782 - Homo sapiens cDNA FLJ20775 fis, clone COL06005.
BC122526 - Homo sapiens sorbin and SH3 domain containing 2, mRNA (cDNA clone IMAGE:40017087), **** WARNING: chimeric clone ****.
JD354919 - Sequence 335943 from Patent EP1572962.
JD171934 - Sequence 152958 from Patent EP1572962.
JD494801 - Sequence 475825 from Patent EP1572962.
JD134179 - Sequence 115203 from Patent EP1572962.
JD283035 - Sequence 264059 from Patent EP1572962.
JD344455 - Sequence 325479 from Patent EP1572962.
JD186723 - Sequence 167747 from Patent EP1572962.
JD106713 - Sequence 87737 from Patent EP1572962.
JD510615 - Sequence 491639 from Patent EP1572962.
JD204625 - Sequence 185649 from Patent EP1572962.
JD338646 - Sequence 319670 from Patent EP1572962.
JD363537 - Sequence 344561 from Patent EP1572962.
JD453045 - Sequence 434069 from Patent EP1572962.
JD552674 - Sequence 533698 from Patent EP1572962.
JD563720 - Sequence 544744 from Patent EP1572962.
JD303592 - Sequence 284616 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A8Q3WKK4, A0A8Q3WKK4_HUMAN, NM_001395207, SORBS2 , uc330zmu.1, uc330zmu.2
UCSC ID: ENST00000695409.1_6
RefSeq Accession: NM_001395207.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.