ID:SNX17_HUMAN DESCRIPTION: RecName: Full=Sorting nexin-17; FUNCTION: May be involved in several stages of intracellular protein trafficking. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)). SUBUNIT: Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus). INTERACTION: P16333:NCK1; NbExp=3; IntAct=EBI-1752620, EBI-389883; P19174:PLCG1; NbExp=2; IntAct=EBI-1752620, EBI-79387; SUBCELLULAR LOCATION: Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. DOMAIN: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes. SIMILARITY: Belongs to the sorting nexin family. SIMILARITY: Contains 1 PX (phox homology) domain. SIMILARITY: Contains 1 Ras-associating domain. SEQUENCE CAUTION: Sequence=BAA06542.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15036
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003279 cardiac septum development GO:0006707 cholesterol catabolic process GO:0006886 intracellular protein transport GO:0006898 receptor-mediated endocytosis GO:0007165 signal transduction GO:0015031 protein transport GO:0016197 endosomal transport GO:0030100 regulation of endocytosis GO:0035904 aorta development GO:0060976 coronary vasculature development GO:1990126 retrograde transport, endosome to plasma membrane
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
