The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60906
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004767 sphingomyelin phosphodiesterase activity GO:0016787 hydrolase activity GO:0046872 metal ion binding
Biological Process: GO:0006629 lipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006684 sphingomyelin metabolic process GO:0009612 response to mechanical stimulus GO:0035556 intracellular signal transduction GO:0046513 ceramide biosynthetic process GO:2000304 positive regulation of ceramide biosynthetic process
BioCarta from NCI Cancer Genome Anatomy Project h_edg1Pathway - Phospholipids as signalling intermediaries
Reactome (by CSHL, EBI, and GO)
Protein O60906 (Reactome details) participates in the following event(s):
R-HSA-193672 Sphingomyelinase is activated by the NGF:p75NTR complex R-HSA-5626981 TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 R-HSA-193706 Production of ceramide which can activate JNK and other targets R-HSA-1606273 Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) R-HSA-193681 Ceramide signalling R-HSA-5626978 TNFR1-mediated ceramide production R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-75893 TNF signaling R-HSA-73887 Death Receptor Signalling R-HSA-1660662 Glycosphingolipid metabolism R-HSA-162582 Signal Transduction R-HSA-428157 Sphingolipid metabolism R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
