Human Gene SLC2A3 (ENST00000075120.12_7) from GENCODE V47lift37
  Description: solute carrier family 2 member 3 (from RefSeq NM_006931.3)
Gencode Transcript: ENST00000075120.12_7
Gencode Gene: ENSG00000059804.18_12
Transcript (Including UTRs)
   Position: hg19 chr12:8,071,826-8,088,783 Size: 16,958 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr12:8,074,009-8,088,630 Size: 14,622 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:8,071,826-8,088,783)mRNA (may differ from genome)Protein (496 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GTR3_HUMAN
DESCRIPTION: RecName: Full=Solute carrier family 2, facilitated glucose transporter member 3; AltName: Full=Glucose transporter type 3, brain; Short=GLUT-3;
FUNCTION: Facilitative glucose transporter. Probably a neuronal glucose transporter.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in brain. Expressed in many tissues.
SIMILARITY: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SLC2A3
Diseases sorted by gene-association score: huntington disease* (9), early onset absence epilepsy (6), krukenberg carcinoma (6), xanthogranulomatous cholecystitis (5), fetal macrosomia (5), persistent fetal circulation syndrome (5), diabetes mellitus, noninsulin-dependent (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 371.26 RPKM in Whole Blood
Total median expression: 1313.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.30153-0.231 Picture PostScript Text
3' UTR -639.602183-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002945 - Glc_transpt_3
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
IPR005828 - Sub_transporter
IPR003663 - Sugar/inositol_transpt
IPR005829 - Sugar_transporter_CS

Pfam Domains:
PF00083 - Sugar (and other) transporter
PF07690 - Major Facilitator Superfamily

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on P11169
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity
GO:0005355 glucose transmembrane transporter activity
GO:0005536 glucose binding
GO:0022857 transmembrane transporter activity
GO:0033300 dehydroascorbic acid transporter activity
GO:0055056 D-glucose transmembrane transporter activity

Biological Process:
GO:0005975 carbohydrate metabolic process
GO:0008643 carbohydrate transport
GO:0019852 L-ascorbic acid metabolic process
GO:0043312 neutrophil degranulation
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
GO:1904659 glucose transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030667 secretory granule membrane
GO:0035579 specific granule membrane
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane


-  Descriptions from all associated GenBank mRNAs
  JD294028 - Sequence 275052 from Patent EP1572962.
HV708953 - JP 2012506450-A/51: Methods for treating eye disorders.
LF384190 - JP 2014500723-A/191693: Polycomb-Associated Non-Coding RNAs.
AB209607 - Homo sapiens mRNA for solute carrier family 2 (facilitated glucose transporter), member 3 variant protein.
FW339985 - Screening.
LP895259 - Sequence 123 from Patent EP3253886.
M20681 - Human glucose transporter-like protein-III (GLUT3), complete cds.
AK074861 - Homo sapiens cDNA FLJ90380 fis, clone NT2RP2005027, highly similar to GLUCOSE TRANSPORTER TYPE 3, BRAIN.
LF365690 - JP 2014500723-A/173193: Polycomb-Associated Non-Coding RNAs.
LF365691 - JP 2014500723-A/173194: Polycomb-Associated Non-Coding RNAs.
JD078915 - Sequence 59939 from Patent EP1572962.
JD367047 - Sequence 348071 from Patent EP1572962.
JD258758 - Sequence 239782 from Patent EP1572962.
JD111273 - Sequence 92297 from Patent EP1572962.
JD404920 - Sequence 385944 from Patent EP1572962.
JD448241 - Sequence 429265 from Patent EP1572962.
JD205235 - Sequence 186259 from Patent EP1572962.
JD125531 - Sequence 106555 from Patent EP1572962.
JD055143 - Sequence 36167 from Patent EP1572962.
JD306267 - Sequence 287291 from Patent EP1572962.
JD169584 - Sequence 150608 from Patent EP1572962.
JD529357 - Sequence 510381 from Patent EP1572962.
JD494952 - Sequence 475976 from Patent EP1572962.
JD548738 - Sequence 529762 from Patent EP1572962.
JD395339 - Sequence 376363 from Patent EP1572962.
JD125530 - Sequence 106554 from Patent EP1572962.
JD169583 - Sequence 150607 from Patent EP1572962.
JD208603 - Sequence 189627 from Patent EP1572962.
JD158750 - Sequence 139774 from Patent EP1572962.
JD522410 - Sequence 503434 from Patent EP1572962.
JD288978 - Sequence 270002 from Patent EP1572962.
JD080424 - Sequence 61448 from Patent EP1572962.
JD320075 - Sequence 301099 from Patent EP1572962.
JD312935 - Sequence 293959 from Patent EP1572962.
JD255447 - Sequence 236471 from Patent EP1572962.
JD271756 - Sequence 252780 from Patent EP1572962.
JD500680 - Sequence 481704 from Patent EP1572962.
JD504629 - Sequence 485653 from Patent EP1572962.
LF365692 - JP 2014500723-A/173195: Polycomb-Associated Non-Coding RNAs.
BC039196 - Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 3, mRNA (cDNA clone MGC:21198 IMAGE:4396508), complete cds.
JD557790 - Sequence 538814 from Patent EP1572962.
JD474008 - Sequence 455032 from Patent EP1572962.
LF365698 - JP 2014500723-A/173201: Polycomb-Associated Non-Coding RNAs.
JD539567 - Sequence 520591 from Patent EP1572962.
JD507889 - Sequence 488913 from Patent EP1572962.
JD245368 - Sequence 226392 from Patent EP1572962.
LF365699 - JP 2014500723-A/173202: Polycomb-Associated Non-Coding RNAs.
JD549779 - Sequence 530803 from Patent EP1572962.
JD355268 - Sequence 336292 from Patent EP1572962.
LF365701 - JP 2014500723-A/173204: Polycomb-Associated Non-Coding RNAs.
JD295539 - Sequence 276563 from Patent EP1572962.
JD208472 - Sequence 189496 from Patent EP1572962.
LF365702 - JP 2014500723-A/173205: Polycomb-Associated Non-Coding RNAs.
LF207379 - JP 2014500723-A/14882: Polycomb-Associated Non-Coding RNAs.
JD541039 - Sequence 522063 from Patent EP1572962.
JD221742 - Sequence 202766 from Patent EP1572962.
JD267959 - Sequence 248983 from Patent EP1572962.
LF365704 - JP 2014500723-A/173207: Polycomb-Associated Non-Coding RNAs.
JD550857 - Sequence 531881 from Patent EP1572962.
JD310295 - Sequence 291319 from Patent EP1572962.
JD309637 - Sequence 290661 from Patent EP1572962.
LF365706 - JP 2014500723-A/173209: Polycomb-Associated Non-Coding RNAs.
JD292996 - Sequence 274020 from Patent EP1572962.
JD204897 - Sequence 185921 from Patent EP1572962.
JD299709 - Sequence 280733 from Patent EP1572962.
JD255402 - Sequence 236426 from Patent EP1572962.
LF365709 - JP 2014500723-A/173212: Polycomb-Associated Non-Coding RNAs.
AK304509 - Homo sapiens cDNA FLJ58410 complete cds, highly similar to Solute carrier family 2, facilitated glucosetransporter member 3.
JD329536 - Sequence 310560 from Patent EP1572962.
LF365711 - JP 2014500723-A/173214: Polycomb-Associated Non-Coding RNAs.
AK298673 - Homo sapiens cDNA FLJ57557 complete cds, highly similar to Solute carrier family 2, facilitated glucose transporter member 3.
DQ891118 - Synthetic construct clone IMAGE:100003748; FLH169470.01X; RZPDo839C0996D solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3) gene, encodes complete protein.
DQ894297 - Synthetic construct Homo sapiens clone IMAGE:100008757; FLH169466.01L; RZPDo839C0995D solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3) gene, encodes complete protein.
DQ894299 - Synthetic construct Homo sapiens clone IMAGE:100008759; FLH263686.01L; RZPDo839C1195D solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3) gene, encodes complete protein.
CR457413 - Homo sapiens full open reading frame cDNA clone RZPDo834A0914D for gene SLC2A3, solute carrier family 2 (facilitated glucose transporter), member 3; complete cds, incl. stopcodon.
AK312386 - Homo sapiens cDNA, FLJ92716, Homo sapiens solute carrier family 2 (facilitated glucosetransporter), member 3 (SLC2A3), mRNA.
KJ892147 - Synthetic construct Homo sapiens clone ccsbBroadEn_01541 SLC2A3 gene, encodes complete protein.
LF365713 - JP 2014500723-A/173216: Polycomb-Associated Non-Coding RNAs.
AY034634 - Homo sapiens glucose transporter-like protein III (GLUT3) mRNA, partial cds.
LF365716 - JP 2014500723-A/173219: Polycomb-Associated Non-Coding RNAs.
LF365717 - JP 2014500723-A/173220: Polycomb-Associated Non-Coding RNAs.
LF365719 - JP 2014500723-A/173222: Polycomb-Associated Non-Coding RNAs.
LF365722 - JP 2014500723-A/173225: Polycomb-Associated Non-Coding RNAs.
LF365723 - JP 2014500723-A/173226: Polycomb-Associated Non-Coding RNAs.
LF365724 - JP 2014500723-A/173227: Polycomb-Associated Non-Coding RNAs.
LF365726 - JP 2014500723-A/173229: Polycomb-Associated Non-Coding RNAs.
LF365730 - JP 2014500723-A/173233: Polycomb-Associated Non-Coding RNAs.
CU691674 - Synthetic construct Homo sapiens gateway clone IMAGE:100019674 5' read SLC2A3 mRNA.
LF365733 - JP 2014500723-A/173236: Polycomb-Associated Non-Coding RNAs.
LF365736 - JP 2014500723-A/173239: Polycomb-Associated Non-Coding RNAs.
LF365737 - JP 2014500723-A/173240: Polycomb-Associated Non-Coding RNAs.
LF365740 - JP 2014500723-A/173243: Polycomb-Associated Non-Coding RNAs.
LF365744 - JP 2014500723-A/173247: Polycomb-Associated Non-Coding RNAs.
JD479339 - Sequence 460363 from Patent EP1572962.
JD134218 - Sequence 115242 from Patent EP1572962.
JD447865 - Sequence 428889 from Patent EP1572962.
MA619767 - JP 2018138019-A/191693: Polycomb-Associated Non-Coding RNAs.
MA601267 - JP 2018138019-A/173193: Polycomb-Associated Non-Coding RNAs.
MA601268 - JP 2018138019-A/173194: Polycomb-Associated Non-Coding RNAs.
MA601269 - JP 2018138019-A/173195: Polycomb-Associated Non-Coding RNAs.
MA601275 - JP 2018138019-A/173201: Polycomb-Associated Non-Coding RNAs.
MA601276 - JP 2018138019-A/173202: Polycomb-Associated Non-Coding RNAs.
MA601278 - JP 2018138019-A/173204: Polycomb-Associated Non-Coding RNAs.
MA601279 - JP 2018138019-A/173205: Polycomb-Associated Non-Coding RNAs.
MA601281 - JP 2018138019-A/173207: Polycomb-Associated Non-Coding RNAs.
MA601283 - JP 2018138019-A/173209: Polycomb-Associated Non-Coding RNAs.
MA601286 - JP 2018138019-A/173212: Polycomb-Associated Non-Coding RNAs.
MA601288 - JP 2018138019-A/173214: Polycomb-Associated Non-Coding RNAs.
MA601290 - JP 2018138019-A/173216: Polycomb-Associated Non-Coding RNAs.
MA601293 - JP 2018138019-A/173219: Polycomb-Associated Non-Coding RNAs.
MA601294 - JP 2018138019-A/173220: Polycomb-Associated Non-Coding RNAs.
MA601296 - JP 2018138019-A/173222: Polycomb-Associated Non-Coding RNAs.
MA601299 - JP 2018138019-A/173225: Polycomb-Associated Non-Coding RNAs.
MA601300 - JP 2018138019-A/173226: Polycomb-Associated Non-Coding RNAs.
MA601301 - JP 2018138019-A/173227: Polycomb-Associated Non-Coding RNAs.
MA601303 - JP 2018138019-A/173229: Polycomb-Associated Non-Coding RNAs.
MA601307 - JP 2018138019-A/173233: Polycomb-Associated Non-Coding RNAs.
MA601310 - JP 2018138019-A/173236: Polycomb-Associated Non-Coding RNAs.
MA601313 - JP 2018138019-A/173239: Polycomb-Associated Non-Coding RNAs.
MA601314 - JP 2018138019-A/173240: Polycomb-Associated Non-Coding RNAs.
MA601317 - JP 2018138019-A/173243: Polycomb-Associated Non-Coding RNAs.
MA601321 - JP 2018138019-A/173247: Polycomb-Associated Non-Coding RNAs.
MA442956 - JP 2018138019-A/14882: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_vitCBPathway - Vitamin C in the Brain

Reactome (by CSHL, EBI, and GO)

Protein P11169 (Reactome details) participates in the following event(s):

R-HSA-6799350 Exocytosis of specific granule membrane proteins
R-HSA-6798747 Exocytosis of tertiary granule membrane proteins
R-HSA-6800426 Exocytosis of ficolin-rich granule membrane proteins
R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-8981564 GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol
R-HSA-198818 GLUT1/3 transports extracellular DHvitC to cytosol
R-HSA-6798695 Neutrophil degranulation
R-HSA-189200 Cellular hexose transport
R-HSA-196836 Vitamin C (ascorbate) metabolism
R-HSA-168249 Innate Immune System
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-168256 Immune System
R-HSA-382551 Transport of small molecules
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2R606, D3DUU6, ENST00000075120.1, ENST00000075120.10, ENST00000075120.11, ENST00000075120.2, ENST00000075120.3, ENST00000075120.4, ENST00000075120.5, ENST00000075120.6, ENST00000075120.7, ENST00000075120.8, ENST00000075120.9, GLUT3 , GTR3_HUMAN, NM_006931, P11169, Q6I9U2, Q9UG15, SLC2A3 , uc317cat.1, uc317cat.2
UCSC ID: ENST00000075120.12_7
RefSeq Accession: NM_006931.3
Protein: P11169 (aka GTR3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.