Human Gene SLC25A18 (ENST00000327451.11_4) from GENCODE V47lift37
  Description: solute carrier family 25 member 18, transcript variant 1 (from RefSeq NM_031481.3)
Gencode Transcript: ENST00000327451.11_4
Gencode Gene: ENSG00000182902.14_7
Transcript (Including UTRs)
   Position: hg19 chr22:18,043,198-18,073,761 Size: 30,564 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr22:18,062,711-18,073,002 Size: 10,292 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:18,043,198-18,073,761)mRNA (may differ from genome)Protein (315 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GHC2_HUMAN
DESCRIPTION: RecName: Full=Mitochondrial glutamate carrier 2; Short=GC-2; AltName: Full=Glutamate/H(+) symporter 2; AltName: Full=Solute carrier family 25 member 18;
FUNCTION: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SLC25A18
Diseases sorted by gene-association score: cat eye syndrome (2), phencyclidine abuse (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 54.99 RPKM in Brain - Amygdala
Total median expression: 554.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -164.10479-0.343 Picture PostScript Text
3' UTR -246.30759-0.325 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q9H1K4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005280 hydrogen:amino acid symporter activity
GO:0005314 high-affinity glutamate transmembrane transporter activity
GO:0005515 protein binding
GO:0015293 symporter activity

Biological Process:
GO:0003333 amino acid transmembrane transport
GO:0006811 ion transport
GO:0006839 mitochondrial transport
GO:0015813 L-glutamate transport
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AJ428203 - Homo sapiens partial mRNA for mitochondrial glutamate carrier (GC2 gene), isoform 2.
AY008285 - Homo sapiens solute carrier (SLC25A18) mRNA, complete cds; nuclear gene for mitochondrial product.
BC031644 - Homo sapiens solute carrier family 25 (mitochondrial carrier), member 18, mRNA (cDNA clone MGC:34115 IMAGE:5179038), complete cds.
AK308974 - Homo sapiens cDNA, FLJ99015.
AK095706 - Homo sapiens cDNA FLJ38387 fis, clone FEBRA2004219.
AK309110 - Homo sapiens cDNA, FLJ99151.
JD194233 - Sequence 175257 from Patent EP1572962.
JD126195 - Sequence 107219 from Patent EP1572962.
JD453414 - Sequence 434438 from Patent EP1572962.
JD108926 - Sequence 89950 from Patent EP1572962.
JD468792 - Sequence 449816 from Patent EP1572962.
JD436929 - Sequence 417953 from Patent EP1572962.
JD247836 - Sequence 228860 from Patent EP1572962.
CR456578 - Homo sapiens SLC25A18 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.SLC25A18).
JD538621 - Sequence 519645 from Patent EP1572962.
JD057898 - Sequence 38922 from Patent EP1572962.
JD187363 - Sequence 168387 from Patent EP1572962.
CU689216 - Synthetic construct Homo sapiens gateway clone IMAGE:100018861 5' read SLC25A18 mRNA.
KJ894899 - Synthetic construct Homo sapiens clone ccsbBroadEn_04293 SLC25A18 gene, encodes complete protein.
AB528235 - Synthetic construct DNA, clone: pF1KE0543, Homo sapiens SLC25A18 gene for solute carrier family 25 (mitochondrial carrier), member 18, without stop codon, in Flexi system.
CU013467 - Homo sapiens SLC25A18, mRNA (cDNA clone IMAGE:100000437), complete cds, without stop codon, in Gateway system.
DQ895659 - Synthetic construct Homo sapiens clone IMAGE:100010119; FLH186413.01L; RZPDo839E0461D solute carrier family 25 (mitochondrial carrier), member 18 (SLC25A18) gene, encodes complete protein.
CU013179 - Homo sapiens SLC25A18, mRNA (cDNA clone IMAGE:100000533), complete cds, with stop codon, in Gateway system.
DQ893660 - Synthetic construct clone IMAGE:100006290; FLH186417.01X; RZPDo839E0471D solute carrier family 25 (mitochondrial carrier), member 18 (SLC25A18) gene, encodes complete protein.
JD312564 - Sequence 293588 from Patent EP1572962.
JD343649 - Sequence 324673 from Patent EP1572962.
JD526804 - Sequence 507828 from Patent EP1572962.
JD487716 - Sequence 468740 from Patent EP1572962.
JD227131 - Sequence 208155 from Patent EP1572962.
JD258009 - Sequence 239033 from Patent EP1572962.
JD176737 - Sequence 157761 from Patent EP1572962.
JD313607 - Sequence 294631 from Patent EP1572962.
JD184560 - Sequence 165584 from Patent EP1572962.
JD261799 - Sequence 242823 from Patent EP1572962.
JD292317 - Sequence 273341 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_rhodopsinPathway - Visual Signal Transduction

Reactome (by CSHL, EBI, and GO)

Protein Q9H1K4 (Reactome details) participates in the following event(s):

R-HSA-8875623 SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix
R-HSA-428643 Organic anion transporters
R-HSA-425374 Amino acid and oligopeptide SLC transporters
R-HSA-425393 Metabolism of nitrogenous molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000327451.1, ENST00000327451.10, ENST00000327451.2, ENST00000327451.3, ENST00000327451.4, ENST00000327451.5, ENST00000327451.6, ENST00000327451.7, ENST00000327451.8, ENST00000327451.9, GC2, GHC2_HUMAN, NM_031481, Q9H1K4, SLC25A18 , uc317shc.1, uc317shc.2
UCSC ID: ENST00000327451.11_4
RefSeq Accession: NM_031481.3
Protein: Q9H1K4 (aka GHC2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.