Human Gene SHC3 (ENST00000375835.9_8) from GENCODE V47lift37
  Description: SHC adaptor protein 3 (from RefSeq NM_016848.6)
Gencode Transcript: ENST00000375835.9_8
Gencode Gene: ENSG00000148082.10_10
Transcript (Including UTRs)
   Position: hg19 chr9:91,620,686-91,793,733 Size: 173,048 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr9:91,628,362-91,793,375 Size: 165,014 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:91,620,686-91,793,733)mRNA (may differ from genome)Protein (594 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SHC3_HUMAN
DESCRIPTION: RecName: Full=SHC-transforming protein 3; AltName: Full=Neuronal Shc; Short=N-Shc; AltName: Full=Protein Rai; AltName: Full=SHC-transforming protein C; AltName: Full=Src homology 2 domain-containing-transforming protein C3; Short=SH2 domain protein C3;
FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
SUBUNIT: Interacts with the Trk receptors in a phosphotyrosine- dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.
INTERACTION: P05067:APP; NbExp=2; IntAct=EBI-79084, EBI-77613;
TISSUE SPECIFICITY: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
PTM: Tyrosine phosphorylated.
SIMILARITY: Contains 1 PID domain.
SIMILARITY: Contains 1 SH2 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SHC3
Diseases sorted by gene-association score: sarcomatous intrahepatic cholangiocarcinoma (7), sclerosing hepatic carcinoma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.46 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 65.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -160.50358-0.448 Picture PostScript Text
3' UTR -2611.607676-0.340 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR006019 - PID_domain
IPR006020 - PTyr_interaction_dom
IPR000980 - SH2

Pfam Domains:
PF00017 - SH2 domain
PF00640 - Phosphotyrosine interaction domain (PTB/PID)

SCOP Domains:
50729 - PH domain-like
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on Q92529
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001784 phosphotyrosine binding
GO:0004871 signal transducer activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding

Biological Process:
GO:0000165 MAPK cascade
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007611 learning or memory
GO:0035249 synaptic transmission, glutamatergic
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005575 cellular_component
GO:0005829 cytosol
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  BC026314 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 3, mRNA (cDNA clone MGC:26094 IMAGE:4819086), complete cds.
D84361 - Homo sapiens mRNA for p52 and p64 isoforms of N-Shc, complete cds.
KU176125 - Homo sapiens Shc3 p51 mRNA, complete cds.
DQ896663 - Synthetic construct Homo sapiens clone IMAGE:100011123; FLH196426.01L; RZPDo839D02155D SHC (Src homology 2 domain containing) transforming protein 3 (SHC3) gene, encodes complete protein.
BC042431 - Homo sapiens cDNA clone IMAGE:4821137.
BX538228 - Homo sapiens mRNA; cDNA DKFZp686H1544 (from clone DKFZp686H1544).
AK127258 - Homo sapiens cDNA FLJ45325 fis, clone BRHIP3006717.
BX641139 - Homo sapiens mRNA; cDNA DKFZp686E01148 (from clone DKFZp686E01148).
JD245620 - Sequence 226644 from Patent EP1572962.
JD384523 - Sequence 365547 from Patent EP1572962.
JD386496 - Sequence 367520 from Patent EP1572962.
JD336505 - Sequence 317529 from Patent EP1572962.
JD207143 - Sequence 188167 from Patent EP1572962.
JD261909 - Sequence 242933 from Patent EP1572962.
JD498326 - Sequence 479350 from Patent EP1572962.
JD408912 - Sequence 389936 from Patent EP1572962.
JD479844 - Sequence 460868 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q92529 (Reactome details) participates in the following event(s):

R-HSA-167056 SHC binds to the activated TrkA receptor
R-HSA-8855915 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors
R-HSA-5685366 GRB2-1:SOS1 binds p-Y-SHC
R-HSA-167217 Phospho-Shc dissociates from the TrkA receptor
R-HSA-167019 SHC, complexed with TrkA, is tyrosine-phosphorylated
R-HSA-5686071 GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-167044 Signalling to RAS
R-HSA-8853659 RET signaling
R-HSA-187687 Signalling to ERKs
R-HSA-422475 Axon guidance
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-1266738 Developmental Biology
R-HSA-166520 Signaling by NTRKs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-162582 Signal Transduction
R-HSA-5683057 MAPK family signaling cascades

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000375835.1, ENST00000375835.2, ENST00000375835.3, ENST00000375835.4, ENST00000375835.5, ENST00000375835.6, ENST00000375835.7, ENST00000375835.8, NM_016848, NSHC, Q5T7I7, Q8TAP2, Q92529, Q9UCX5, SHC3_HUMAN, SHCC, uc318mnv.1, uc318mnv.2
UCSC ID: ENST00000375835.9_8
RefSeq Accession: NM_016848.6
Protein: Q92529 (aka SHC3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.