Human Gene SFXN4 (ENST00000355697.7_8) from GENCODE V47lift37
  Description: sideroflexin 4, transcript variant 2 (from RefSeq NR_110305.1)
Gencode Transcript: ENST00000355697.7_8
Gencode Gene: ENSG00000183605.17_10
Transcript (Including UTRs)
   Position: hg19 chr10:120,900,279-120,925,226 Size: 24,948 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr10:120,900,754-120,925,159 Size: 24,406 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:120,900,279-120,925,226)mRNA (may differ from genome)Protein (337 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SFXN4_HUMAN
DESCRIPTION: RecName: Full=Sideroflexin-4; AltName: Full=Breast cancer resistance marker 1;
FUNCTION: Potential iron transporter (By similarity).
SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the sideroflexin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SFXN4
Diseases sorted by gene-association score: combined oxidative phosphorylation deficiency 18* (1369), macrocytic anemia (44)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.28 RPKM in Adrenal Gland
Total median expression: 530.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.9067-0.416 Picture PostScript Text
3' UTR -158.40475-0.333 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004686 - Mtc

Pfam Domains:
PF03820 - Sideroflexins

ModBase Predicted Comparative 3D Structure on Q6P4A7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015075 ion transmembrane transporter activity

Biological Process:
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
GO:0055072 iron ion homeostasis
GO:0055085 transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC050475 - Homo sapiens sideroflexin 4, mRNA (cDNA clone IMAGE:5723583), partial cds.
AF336980 - Homo sapiens breast cancer resistance marker 1 (BCRM1) mRNA, complete cds.
AY269785 - Homo sapiens sideroflexin mRNA, complete cds.
BC063562 - Homo sapiens sideroflexin 4, mRNA (cDNA clone MGC:70957 IMAGE:4996745), complete cds.
JD152796 - Sequence 133820 from Patent EP1572962.
JD176002 - Sequence 157026 from Patent EP1572962.
JD531573 - Sequence 512597 from Patent EP1572962.
JD174956 - Sequence 155980 from Patent EP1572962.
JD261582 - Sequence 242606 from Patent EP1572962.
JD374111 - Sequence 355135 from Patent EP1572962.
JD440404 - Sequence 421428 from Patent EP1572962.
JD315501 - Sequence 296525 from Patent EP1572962.
HQ448063 - Synthetic construct Homo sapiens clone IMAGE:100071442; CCSB012060_01 sideroflexin 4 (SFXN4) gene, encodes complete protein.
KJ895344 - Synthetic construct Homo sapiens clone ccsbBroadEn_04738 SFXN4 gene, encodes complete protein.
CU687762 - Synthetic construct Homo sapiens gateway clone IMAGE:100021721 5' read SFXN4 mRNA.
JD253785 - Sequence 234809 from Patent EP1572962.
AK095295 - Homo sapiens cDNA FLJ37976 fis, clone CTONG2010148.

-  Other Names for This Gene
  Alternate Gene Symbols: BCRM1 , ENST00000355697.1, ENST00000355697.2, ENST00000355697.3, ENST00000355697.4, ENST00000355697.5, ENST00000355697.6, NR_110305, Q6P4A7, Q6WSU4, Q86TD9, SFXN4 , SFXN4_HUMAN, uc317zfc.1, uc317zfc.2
UCSC ID: ENST00000355697.7_8
RefSeq Accession: NM_213649.2
Protein: Q6P4A7 (aka SFXN4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.