Human Gene SEMG2 (ENST00000372769.4_4) from GENCODE V47lift37
  Description: semenogelin 2 (from RefSeq NM_003008.3)
Gencode Transcript: ENST00000372769.4_4
Gencode Gene: ENSG00000124157.7_7
Transcript (Including UTRs)
   Position: hg19 chr20:43,850,014-43,853,099 Size: 3,086 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr20:43,850,031-43,852,022 Size: 1,992 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:43,850,014-43,853,099)mRNA (may differ from genome)Protein (582 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SEMG2_HUMAN
DESCRIPTION: RecName: Full=Semenogelin-2; AltName: Full=Semenogelin II; Short=SGII; Flags: Precursor;
FUNCTION: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
SUBUNIT: Interacts with SERPINA5.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Seminal vesicles, and to a much lesser extent, epididymis.
PTM: Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide.
SIMILARITY: Belongs to the semenogelin family.
WEB RESOURCE: Name=Protein Spotlight; Note=Shackled sperm - Issue 62 of September 2005; URL="http://web.expasy.org/spotlight/back_issues/sptlt062.shtml";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.40 RPKM in Prostate
Total median expression: 0.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00170.000 Picture PostScript Text
3' UTR -51.90212-0.245 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008836 - Semenogelin

Pfam Domains:
PF05474 - Semenogelin

ModBase Predicted Comparative 3D Structure on Q02383
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0019731 antibacterial humoral response
GO:0050817 coagulation
GO:0051291 protein heterooligomerization
GO:1900005 positive regulation of serine-type endopeptidase activity
GO:1901318 negative regulation of flagellated sperm motility

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK291811 - Homo sapiens cDNA FLJ78262 complete cds, highly similar to Homo sapiens semenogelin II (SEMG2), mRNA.
BC005262 - Homo sapiens semenogelin II, mRNA (cDNA clone IMAGE:3951184), partial cds.
M81652 - Homo sapiens semenogelin II mRNA, complete cds.
BC056675 - Homo sapiens semenogelin II, mRNA (cDNA clone IMAGE:6667862), partial cds.
AK312932 - Homo sapiens cDNA, FLJ93383, highly similar to Homo sapiens semenogelin II (SEMG2), mRNA.
AX772816 - Sequence 13 from Patent WO03046180.
BC070306 - Homo sapiens semenogelin II, mRNA (cDNA clone MGC:88306 IMAGE:4356587), complete cds.
AB464703 - Synthetic construct DNA, clone: pF1KB7055, Homo sapiens SEMG2 gene for semenogelin II, without stop codon, in Flexi system.
KJ897538 - Synthetic construct Homo sapiens clone ccsbBroadEn_06932 SEMG2 gene, encodes complete protein.
JD043004 - Sequence 24028 from Patent EP1572962.
JD040841 - Sequence 21865 from Patent EP1572962.
JD050786 - Sequence 31810 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000372769.1, ENST00000372769.2, ENST00000372769.3, NM_003008, Q02383, Q53ZU2, Q6X2M5, Q6X2M6, SEMG2_HUMAN, uc318keu.1, uc318keu.2
UCSC ID: ENST00000372769.4_4
RefSeq Accession: NM_003008.3
Protein: Q02383 (aka SEMG2_HUMAN or SEM2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.