ID:SEC13_HUMAN DESCRIPTION: RecName: Full=Protein SEC13 homolog; AltName: Full=SEC13-like protein 1; AltName: Full=SEC13-related protein; FUNCTION: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. SUBUNIT: At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. At the COPII coat complex: interacts with SEC31A and SEC31B. INTERACTION: P49687:NUP145 (xeno); NbExp=9; IntAct=EBI-1046596, EBI-11730; SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC. SIMILARITY: Belongs to the WD repeat SEC13 family. SIMILARITY: Contains 6 WD repeats. SEQUENCE CAUTION: Sequence=AAH02634.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55735
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005198 structural molecule activity GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0006886 intracellular protein transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0032008 positive regulation of TOR signaling GO:0048208 COPII vesicle coating GO:0051028 mRNA transport GO:0090110 cargo loading into COPII-coated vesicle GO:0090114 COPII-coated vesicle budding GO:1904263 positive regulation of TORC1 signaling
AF052155 - Homo sapiens clone 24761 mRNA sequence. L09260 - Human (chromosome 3p25) membrane protein mRNA. BC002634 - Homo sapiens SEC13 homolog (S. cerevisiae), mRNA (cDNA clone MGC:4272 IMAGE:3605545), complete cds. BC091506 - Homo sapiens SEC13 homolog (S. cerevisiae), mRNA (cDNA clone MGC:111109 IMAGE:30408210), complete cds. AK095629 - Homo sapiens cDNA FLJ38310 fis, clone FCBBF3019839, highly similar to SEC13-RELATED PROTEIN. AB209554 - Homo sapiens mRNA for SEC13-like 1 isoform b variant protein. AK223019 - Homo sapiens mRNA for SEC13-like 1 isoform b variant, clone: HSI15861. AK301999 - Homo sapiens cDNA FLJ56334 complete cds, highly similar to SEC13-related protein. KJ892122 - Synthetic construct Homo sapiens clone ccsbBroadEn_01516 SEC13 gene, encodes complete protein. AB528650 - Synthetic construct DNA, clone: pF1KB6539, Homo sapiens SEC13L1 gene for SEC13 homolog, without stop codon, in Flexi system. CU678078 - Synthetic construct Homo sapiens gateway clone IMAGE:100018915 5' read SEC13 mRNA. EF036494 - Homo sapiens SEC13-like 1 isoform mRNA, partial cds. AK294662 - Homo sapiens cDNA FLJ59881 complete cds, highly similar to SEC13-related protein. EU789555 - Homo sapiens clone UIS231 SEC13 splice variant mRNA, partial cds, alternatively spliced. BC006167 - Homo sapiens SEC13 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3959959), partial cds. DQ574620 - Homo sapiens piRNA piR-42732, complete sequence. JD118166 - Sequence 99190 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P55735 (Reactome details) participates in the following event(s):
R-HSA-983425 Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle R-HSA-983422 Disassembly of COPII coated vesicle R-HSA-204008 SEC31:SEC13 and v-SNARE recruitment R-HSA-5694441 CSNK1D phosphorylates SEC23 R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-203973 Vesicle budding R-HSA-2130731 Formation of COPII vesicle R-HSA-2213243 Fusion of COPII vesicle with Golgi complex R-HSA-983424 Budding of COPII coated vesicle R-HSA-5694439 COPII coat binds TRAPPCII and RAB1:GDP R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-5694418 RAB1:GTP binds USO1 and GORASP1:GOLGA2 R-HSA-5694409 Nucleotide exchange on RAB1 R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-204005 COPII-mediated vesicle transport R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-1280218 Adaptive Immune System R-HSA-2132295 MHC class II antigen presentation R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-168256 Immune System R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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Common Gene Haplotype Alleles 
