ID:RRAGC_HUMAN DESCRIPTION: RecName: Full=Ras-related GTP-binding protein C; Short=Rag C; Short=RagC; AltName: Full=GTPase-interacting protein 2; AltName: Full=TIB929; FUNCTION: Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. SUBUNIT: Binds GTP. Forms a heterodimer with RRAGA, in a sequence- independent manner, and RRAGB. Heterodimerization stabilizes PPAG proteins. In complex with RRAGA or RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. It is regulated by amino acids, since amino acid stimulation of cells increase the GTP-loading of RRAGB. Interacts with NOL8. INTERACTION: Q7L523:RRAGA; NbExp=11; IntAct=EBI-752390, EBI-752376; Q5VZM2:RRAGB; NbExp=4; IntAct=EBI-752390, EBI-993049; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA. SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family. SEQUENCE CAUTION: Sequence=BAB14548.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00025 - ADP-ribosylation factor family PF04670 - Gtr1/RagA G protein conserved region PF09439 - Signal recognition particle receptor beta subunit
ModBase Predicted Comparative 3D Structure on Q9HB90
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
