ID:RL5_HUMAN DESCRIPTION: RecName: Full=60S ribosomal protein L5; FUNCTION: Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA. INTERACTION: P43146:DCC; NbExp=7; IntAct=EBI-358018, EBI-1222919; Q63155:Dcc (xeno); NbExp=4; IntAct=EBI-358018, EBI-1798965; SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. DISEASE: Defects in RPL5 are the cause of Diamond-Blackfan anemia type 6 (DBA6) [MIM:612561]. DBA6 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. SIMILARITY: Belongs to the ribosomal protein L18P family. WEB RESOURCE: Name=Diamond-Blackfan Anemia mutation database; URL="http://www.dbagenes.unito.it/home.php?select_db=RPL5";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P46777
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000027 ribosomal large subunit assembly GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006364 rRNA processing GO:0006412 translation GO:0006413 translational initiation GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0010628 positive regulation of gene expression GO:0042273 ribosomal large subunit biogenesis GO:0045727 positive regulation of translation GO:0050821 protein stabilization GO:1901796 regulation of signal transduction by p53 class mediator GO:1904667 negative regulation of ubiquitin protein ligase activity GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000435 negative regulation of protein neddylation
KJ901710 - Synthetic construct Homo sapiens clone ccsbBroadEn_11104 RPL5 gene, encodes complete protein. AK092963 - Homo sapiens cDNA FLJ35644 fis, clone SPLEN2012525, highly similar to 60S RIBOSOMAL PROTEIN L5. AK314720 - Homo sapiens cDNA, FLJ95579, Homo sapiens ribosomal protein L5 (RPL5), mRNA. AK095815 - Homo sapiens cDNA FLJ38496 fis, clone FELIV1000137, highly similar to 60S RIBOSOMAL PROTEIN L5. AB055762 - Homo sapiens mRNA for ribosomal protein L5, partial cds. BC109370 - Homo sapiens ribosomal protein L5, mRNA (cDNA clone MGC:117339 IMAGE:5736022), complete cds. AF113210 - Homo sapiens MSTP030 mRNA, complete cds. BC132970 - Homo sapiens ribosomal protein L5, mRNA (cDNA clone MGC:164601 IMAGE:40146992), complete cds. BC132972 - Homo sapiens ribosomal protein L5, mRNA (cDNA clone MGC:164603 IMAGE:40146994), complete cds. BC001882 - Homo sapiens ribosomal protein L5, mRNA (cDNA clone IMAGE:3544216), complete cds. AK222604 - Homo sapiens mRNA for ribosomal protein L5 variant, clone: CAS05133. U14966 - Human ribosomal protein L5 mRNA, complete cds. AB208980 - Homo sapiens mRNA for ribosomal protein L5 variant protein. AB464162 - Synthetic construct DNA, clone: pF1KB3448, Homo sapiens RPL5 gene for ribosomal protein L5, without stop codon, in Flexi system. AX419933 - Sequence 270 from Patent WO0198537. JD027156 - Sequence 8180 from Patent EP1572962. JD035974 - Sequence 16998 from Patent EP1572962. BC012937 - Homo sapiens ribosomal protein L5, mRNA (cDNA clone IMAGE:3853527). JD022601 - Sequence 3625 from Patent EP1572962. JD022602 - Sequence 3626 from Patent EP1572962. JD023600 - Sequence 4624 from Patent EP1572962. JD026813 - Sequence 7837 from Patent EP1572962. JD035555 - Sequence 16579 from Patent EP1572962. CS330179 - Sequence 30 from Patent WO2006063356. CS330190 - Sequence 46 from Patent WO2006063356. U66590 - Human ribosomal protein L5 pseudogene mRNA, partial cds. JD035664 - Sequence 16688 from Patent EP1572962. U76609 - Human ribosomal L5 protein mRNA, partial cds. JD025417 - Sequence 6441 from Patent EP1572962. JD028290 - Sequence 9314 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P46777 (Reactome details) participates in the following event(s):
R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-156826 Dissociation of L13a from the 60s ribosomal subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-156827 L13a-mediated translation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72613 Eukaryotic Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
