ID:RL4_HUMAN DESCRIPTION: RecName: Full=60S ribosomal protein L4; AltName: Full=60S ribosomal protein L1; SUBUNIT: May bind IPO9 with low affinity. Interacts with RBM3 (By similarity). SIMILARITY: Belongs to the ribosomal protein L4P family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P36578
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC009888 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone MGC:16528 IMAGE:4025800), complete cds. BC010151 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone MGC:19674 IMAGE:3353592), complete cds. BC001365 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone MGC:2201 IMAGE:3051487), complete cds. BC018840 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone IMAGE:3051153). AK291117 - Homo sapiens cDNA FLJ78445 complete cds, highly similar to Homo sapiens ribosomal protein L4 (RPL4), mRNA. BC014653 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone MGC:20247 IMAGE:4636179), complete cds. BC095427 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone MGC:110964 IMAGE:30711782), complete cds. BC066925 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone MGC:87190 IMAGE:5259747), complete cds. AK298224 - Homo sapiens cDNA FLJ51018 complete cds, highly similar to 60S ribosomal protein L4. L20868 - Homo sapiens ribosomal protein L4 (RPL4) mRNA, complete cds. BC007996 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone MGC:15373 IMAGE:3546003), complete cds. BC007259 - Homo sapiens cDNA clone IMAGE:3050317, **** WARNING: chimeric clone ****. AK297490 - Homo sapiens cDNA FLJ50996 complete cds, highly similar to 60S ribosomal protein L4. AK125772 - Homo sapiens cDNA FLJ43784 fis, clone TESTI2051867, highly similar to 60S ribosomal protein L4. BC030000 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone IMAGE:5110884). AK223057 - Homo sapiens mRNA for ribosomal protein L4 variant, clone: KAT00378. BC005817 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone MGC:11073 IMAGE:3688641), complete cds. BC001010 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone IMAGE:2961234). BC040610 - Homo sapiens ribosomal protein L4, mRNA (cDNA clone IMAGE:3897039). BC002450 - Homo sapiens cDNA clone IMAGE:3344612, **** WARNING: chimeric clone ****. AK297484 - Homo sapiens cDNA FLJ50994 complete cds, moderately similar to 60S ribosomal protein L4. AB208977 - Homo sapiens mRNA for ribosomal protein L4 variant protein. AK130784 - Homo sapiens cDNA FLJ27274 fis, clone TMS00767, highly similar to 60S ribosomal protein L4. AK291859 - Homo sapiens cDNA FLJ78454 complete cds, highly similar to Homo sapiens ribosomal protein L4 (RPL4), mRNA. D23660 - Homo sapiens mRNA for ribosomal protein, complete cds. DQ892189 - Synthetic construct clone IMAGE:100004819; FLH183868.01X; RZPDo839H06142D ribosomal protein L4 (RPL4) gene, encodes complete protein. KJ892022 - Synthetic construct Homo sapiens clone ccsbBroadEn_01416 RPL4 gene, encodes complete protein. DQ895383 - Synthetic construct Homo sapiens clone IMAGE:100009843; FLH183864.01L; RZPDo839H06141D ribosomal protein L4 (RPL4) gene, encodes complete protein. AB463231 - Synthetic construct DNA, clone: pF1KB3433, Homo sapiens RPL4 gene for ribosomal protein L4, without stop codon, in Flexi system. DQ570914 - Homo sapiens piRNA piR-31026, complete sequence. AK294113 - Homo sapiens cDNA FLJ56689 complete cds, highly similar to 60S ribosomal protein L4. DQ578787 - Homo sapiens piRNA piR-46899, complete sequence. CU675891 - Synthetic construct Homo sapiens gateway clone IMAGE:100019347 5' read RPL4 mRNA. JD544472 - Sequence 525496 from Patent EP1572962. JD180811 - Sequence 161835 from Patent EP1572962. JD420874 - Sequence 401898 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P36578 (Reactome details) participates in the following event(s):
R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-156826 Dissociation of L13a from the 60s ribosomal subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-156827 L13a-mediated translation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72613 Eukaryotic Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
