ID:RL23_HUMAN DESCRIPTION: RecName: Full=60S ribosomal protein L23; AltName: Full=60S ribosomal protein L17; SIMILARITY: Belongs to the ribosomal protein L14P family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62829
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001223 transcription coactivator binding GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0005515 protein binding GO:0031625 ubiquitin protein ligase binding GO:0070180 large ribosomal subunit rRNA binding GO:1990948 ubiquitin ligase inhibitor activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006412 translation GO:0006413 translational initiation GO:0006610 ribosomal protein import into nucleus GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008284 positive regulation of cell proliferation GO:0010628 positive regulation of gene expression GO:0032986 protein-DNA complex disassembly GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050821 protein stabilization GO:0071157 negative regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0072717 cellular response to actinomycin D GO:1901798 positive regulation of signal transduction by p53 class mediator GO:1904667 negative regulation of ubiquitin protein ligase activity GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
JD281314 - Sequence 262338 from Patent EP1572962. JD281315 - Sequence 262339 from Patent EP1572962. JD160686 - Sequence 141710 from Patent EP1572962. JD152912 - Sequence 133936 from Patent EP1572962. JD557431 - Sequence 538455 from Patent EP1572962. JD564084 - Sequence 545108 from Patent EP1572962. JD517566 - Sequence 498590 from Patent EP1572962. JD344641 - Sequence 325665 from Patent EP1572962. JD489815 - Sequence 470839 from Patent EP1572962. JD501352 - Sequence 482376 from Patent EP1572962. JD176409 - Sequence 157433 from Patent EP1572962. JD138408 - Sequence 119432 from Patent EP1572962. X55954 - Human mRNA for HL23 ribosomal protein homologue. E01932 - cDNA encoding human ribosomal protein. BC003518 - Homo sapiens, Similar to ribosomal protein L23, clone IMAGE:3606198, mRNA, partial cds. AK024749 - Homo sapiens cDNA: FLJ21096 fis, clone CAS03926. BC104651 - Homo sapiens ribosomal protein L23, mRNA (cDNA clone MGC:111167 IMAGE:6736195), complete cds. X52839 - Human mRNA for ribosomal protein L17. BC034378 - Homo sapiens ribosomal protein L23, mRNA (cDNA clone IMAGE:5186030), with apparent retained intron. BC062716 - Homo sapiens ribosomal protein L23, mRNA (cDNA clone MGC:72008 IMAGE:4094608), complete cds. KJ892752 - Synthetic construct Homo sapiens clone ccsbBroadEn_02146 RPL23 gene, encodes complete protein. KJ898003 - Synthetic construct Homo sapiens clone ccsbBroadEn_07397 RPL23 gene, encodes complete protein. DQ893218 - Synthetic construct clone IMAGE:100005848; FLH195338.01X; RZPDo839B04152D ribosomal protein L23 (RPL23) gene, encodes complete protein. DQ896547 - Synthetic construct Homo sapiens clone IMAGE:100011007; FLH195334.01L; RZPDo839B04151D ribosomal protein L23 (RPL23) gene, encodes complete protein. AB528571 - Synthetic construct DNA, clone: pF1KB3444, Homo sapiens RPL23 gene for ribosomal protein L23, without stop codon, in Flexi system. AK095288 - Homo sapiens cDNA FLJ37969 fis, clone CTONG2009938. D28349 - Homo sapiens mRNA for ribosomal protein L23, partial cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P62829 (Reactome details) participates in the following event(s):
R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-156826 Dissociation of L13a from the 60s ribosomal subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-156827 L13a-mediated translation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72613 Eukaryotic Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
