Human Gene RNH1 (ENST00000354420.7_7) from GENCODE V47lift37
  Description: ribonuclease/angiogenin inhibitor 1, transcript variant 6 (from RefSeq NM_203387.3)
Gencode Transcript: ENST00000354420.7_7
Gencode Gene: ENSG00000023191.17_14
Transcript (Including UTRs)
   Position: hg19 chr11:494,515-507,242 Size: 12,728 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr11:494,691-502,162 Size: 7,472 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:494,515-507,242)mRNA (may differ from genome)Protein (461 aa)
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-  Comments and Description Text from UniProtKB
  ID: RINI_HUMAN
DESCRIPTION: RecName: Full=Ribonuclease inhibitor; AltName: Full=Placental ribonuclease inhibitor; Short=Placental RNase inhibitor; AltName: Full=Ribonuclease/angiogenin inhibitor 1; Short=RAI;
FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
SUBUNIT: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
INTERACTION: P03950:ANG; NbExp=2; IntAct=EBI-1237106, EBI-525291; P07998:RNASE1; NbExp=2; IntAct=EBI-1237106, EBI-2823523; P61823:RNASE1 (xeno); NbExp=3; IntAct=EBI-1237106, EBI-908364;
SUBCELLULAR LOCATION: Cytoplasm.
DOMAIN: The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNAses via a large protein interaction surface on its interior side.
PTM: The N-terminus is blocked.
PTM: At least 30 of the 32 cysteine residues are in the reduced form.
SIMILARITY: Contains 15 LRR (leucine-rich) repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RNH1
Diseases sorted by gene-association score: osteogenesis imperfecta, type v (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 65.53 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 1638.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -131.60390-0.337 Picture PostScript Text
3' UTR -39.40176-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003590 - Leu-rich_rpt_RNase_inh_sub-typ

Pfam Domains:
PF00560 - Leucine Rich Repeat
PF13516 - Leucine Rich repeat
PF18779 - Capping Ribonuclease inhibitor Leucine Rich Repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A4Y - X-ray MuPIT 1Z7X - X-ray MuPIT 2BEX - X-ray MuPIT 2Q4G - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P13489
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008428 ribonuclease inhibitor activity

Biological Process:
GO:0006402 mRNA catabolic process
GO:0043086 negative regulation of catalytic activity
GO:0045765 regulation of angiogenesis

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032311 angiogenin-PRI complex
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AL161967 - Homo sapiens mRNA; cDNA DKFZp434K249 (from clone DKFZp434K249).
LF384314 - JP 2014500723-A/191817: Polycomb-Associated Non-Coding RNAs.
AK057144 - Homo sapiens cDNA FLJ32582 fis, clone SPLEN2000310.
BC011186 - Homo sapiens ribonuclease/angiogenin inhibitor 1, mRNA (cDNA clone IMAGE:4151106), partial cds.
BC003506 - Homo sapiens ribonuclease/angiogenin inhibitor 1, mRNA (cDNA clone MGC:10457 IMAGE:2959514), complete cds.
BC024037 - Homo sapiens ribonuclease/angiogenin inhibitor 1, mRNA (cDNA clone MGC:10747 IMAGE:2959514), complete cds.
BC047730 - Homo sapiens ribonuclease/angiogenin inhibitor 1, mRNA (cDNA clone MGC:54054 IMAGE:5788220), complete cds.
BC003075 - Homo sapiens cDNA clone IMAGE:3506537, **** WARNING: chimeric clone ****.
BC000677 - Homo sapiens ribonuclease/angiogenin inhibitor 1, mRNA (cDNA clone MGC:844 IMAGE:3349381), complete cds.
BC014629 - Homo sapiens ribonuclease/angiogenin inhibitor 1, mRNA (cDNA clone MGC:4569 IMAGE:3029730), complete cds.
BC011500 - Homo sapiens ribonuclease/angiogenin inhibitor 1, mRNA (cDNA clone MGC:18200 IMAGE:4155804), complete cds.
AB209196 - Homo sapiens mRNA for ribonuclease/angiogenin inhibitor variant protein.
AK311379 - Homo sapiens cDNA, FLJ18421.
X13973 - Human mRNA for ribonuclease/angiogenin inhibitor (RAI).
M22414 - Human placental ribonuclease inhibitor mRNA, complete cds.
M36717 - Human ribonuclease/angiogenin inhibitor (RAI) mRNA, complete cds.
JD539653 - Sequence 520677 from Patent EP1572962.
JD319199 - Sequence 300223 from Patent EP1572962.
JD393420 - Sequence 374444 from Patent EP1572962.
HM005477 - Homo sapiens clone HTL-T-164 testicular tissue protein Li 164 mRNA, complete cds.
JD487274 - Sequence 468298 from Patent EP1572962.
JF432836 - Synthetic construct Homo sapiens clone IMAGE:100074156 ribonuclease/angiogenin inhibitor 1 (RNH1) gene, encodes complete protein.
KJ897476 - Synthetic construct Homo sapiens clone ccsbBroadEn_06870 RNH1 gene, encodes complete protein.
KJ897477 - Synthetic construct Homo sapiens clone ccsbBroadEn_06871 RNH1 gene, encodes complete protein.
LF370552 - JP 2014500723-A/178055: Polycomb-Associated Non-Coding RNAs.
DL492073 - Novel nucleic acids.
DL490619 - Novel nucleic acids.
AK027172 - Homo sapiens cDNA: FLJ23519 fis, clone LNG04908.
JD024986 - Sequence 6010 from Patent EP1572962.
JD027673 - Sequence 8697 from Patent EP1572962.
JD021884 - Sequence 2908 from Patent EP1572962.
JD030271 - Sequence 11295 from Patent EP1572962.
AK308340 - Homo sapiens cDNA, FLJ98288.
AK310173 - Homo sapiens cDNA, FLJ17215.
LF370554 - JP 2014500723-A/178057: Polycomb-Associated Non-Coding RNAs.
LF370555 - JP 2014500723-A/178058: Polycomb-Associated Non-Coding RNAs.
JD398065 - Sequence 379089 from Patent EP1572962.
JD143256 - Sequence 124280 from Patent EP1572962.
JD043298 - Sequence 24322 from Patent EP1572962.
MA619891 - JP 2018138019-A/191817: Polycomb-Associated Non-Coding RNAs.
MA606129 - JP 2018138019-A/178055: Polycomb-Associated Non-Coding RNAs.
MA606131 - JP 2018138019-A/178057: Polycomb-Associated Non-Coding RNAs.
MA606132 - JP 2018138019-A/178058: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000354420.1, ENST00000354420.2, ENST00000354420.3, ENST00000354420.4, ENST00000354420.5, ENST00000354420.6, NM_203387, P13489, PRI, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6, RINI_HUMAN, RNH, uc317ypq.1, uc317ypq.2
UCSC ID: ENST00000354420.7_7
RefSeq Accession: NM_203387.3
Protein: P13489 (aka RINI_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.