ID:TF65_HUMAN DESCRIPTION: RecName: Full=Transcription factor p65; AltName: Full=Nuclear factor NF-kappa-B p65 subunit; AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; FUNCTION: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. SUBUNIT: Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-c-Rel complex. Homodimer; component of the NF- kappa-B p65-p65 complex. Component of the NF-kappa-B p65-p52 complex. May interact with ETHE1. Binds AES and TLE1. Interacts with TP53BP2. Binds to and is phosphorylated by the activated form of either RPS6KA4 or RPS6KA5. Interacts with ING4 and this interaction may be indirect. Interacts with CARM1, USP48 and UNC5CL. Interacts with IRAK1BP1 (By similarity).Interacts with NFKBID (By similarity). Interacts with NFKBIA. Interacts with GSK3B. Interacts with NFKBIB (By similarity). Interacts with NFKBIE. Interacts with NFKBIZ. Interacts with EHMT1 (via ANK repeats) (By similarity). Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HDAC3; HDAC3 mediates the deacetylation of RELA. Interacts with HDAC1; the interaction requires non-phosphorylated RELA. Interacts with CBP; the interaction requires phosphorylated RELA. Interacts (phosphorylated at 'Thr-254') with PIN1; the interaction inhibits p65 binding to NFKBIA. Interacts with SOCS1. Interacts with UXT. Interacts with MTDH and PHF11. Interacts with ARRB2. Interacts with human respiratory syncytial virus (HRSV) protein M2-1. Interacts with NFKBIA (when phosphorylated), the interaction is direct; phosphorylated NFKBIA is part of a SCF(BTRC)-like complex lacking CUL1. Interacts with RNF25. Interacts (via C-terminus) with DDX1. Interacts with UFL1 and COMMD1. Interacts with BRMS1; this promotes deacetylation of 'Lys- 310'. Interacts with NOTCH2 (By similarity). Directly interacts with MEN1; this interaction represses NFKB-mediated transactivation. Interacts with AKIP1, which promotes the phosphorylation and nuclear retention of RELA. Interacts (via the RHD) with GFI1; the interaction, after bacterial lipopolysaccharide (LPS) stimulation, inhibits the transcriptional activity by interfering with the DNA-binding activity to target gene promoter DNA. INTERACTION: Self; NbExp=3; IntAct=EBI-73886, EBI-73886; Q9NY61:AATF; NbExp=3; IntAct=EBI-73886, EBI-372428; P18847:ATF3; NbExp=4; IntAct=EBI-73886, EBI-712767; Q96JB5:CDK5RAP3; NbExp=4; IntAct=EBI-73886, EBI-718818; O15111:CHUK; NbExp=2; IntAct=EBI-73886, EBI-81249; Q8N668:COMMD1; NbExp=7; IntAct=EBI-73886, EBI-1550112; Q92793:CREBBP; NbExp=3; IntAct=EBI-73886, EBI-81215; Q08211:DHX9; NbExp=4; IntAct=EBI-73886, EBI-352022; Q9H9B1:EHMT1; NbExp=3; IntAct=EBI-73886, EBI-766087; P03372:ESR1; NbExp=7; IntAct=EBI-73886, EBI-78473; Q99684:GFI1; NbExp=2; IntAct=EBI-73886, EBI-949368; Q13547:HDAC1; NbExp=5; IntAct=EBI-73886, EBI-301834; Q14145:KEAP1; NbExp=4; IntAct=EBI-73886, EBI-751001; P25791:LMO2; NbExp=3; IntAct=EBI-73886, EBI-739696; P53779:MAPK10; NbExp=2; IntAct=EBI-73886, EBI-713543; P19838:NFKB1; NbExp=9; IntAct=EBI-73886, EBI-300010; P25963:NFKBIA; NbExp=12; IntAct=EBI-73886, EBI-307386; Q15653:NFKBIB; NbExp=6; IntAct=EBI-73886, EBI-352889; P0C774:P/V (xeno); NbExp=3; IntAct=EBI-73886, EBI-3650423; P23396:RPS3; NbExp=6; IntAct=EBI-73886, EBI-351193; Q96EB6:SIRT1; NbExp=4; IntAct=EBI-73886, EBI-1802965; Q8N6T7:SIRT6; NbExp=4; IntAct=EBI-73886, EBI-712415; P40763:STAT3; NbExp=4; IntAct=EBI-73886, EBI-518675; P21980:TGM2; NbExp=3; IntAct=EBI-73886, EBI-727668; Q13625-2:TP53BP2; NbExp=6; IntAct=EBI-73886, EBI-287091; Q9UBK9:UXT; NbExp=5; IntAct=EBI-73886, EBI-357355; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation. DOMAIN: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. PTM: Ubiquitinated, leading to its proteasomal degradation. Degradation is required for termination of NF-kappa-B response. PTM: Monomethylated at Lys-310 by SETD6. Monomethylation at Lys- 310 is recognized by the ANK repeats of EHMT1 and promotes the formation of repressed chromatin at target genes, leading to down- regulation of NF-kappa-B transcription factor activity. Phosphorylation at Ser-311 disrupts the interaction with EHMT1 without preventing monomethylation at Lys-310 and relieves the repression of target genes (By similarity). PTM: Phosphorylation at Ser-311 disrupts the interaction with EHMT1 and promotes transcription factor activity (By similarity). Phosphorylation on Ser-536 stimulates acetylation on Lys-310 and interaction with CBP; the phosphorylated and acetylated forms show enhanced transcriptional activity. Phosphorylation at Ser-276 by RPS6KA4 and RPS6KA5 promotes its transactivation and transcriptional activities. PTM: Reversibly acetylated; the acetylation seems to be mediated by CBP, the deacetylation by HDAC3 and SIRT2. Acetylation at Lys- 122 enhances DNA binding and impairs association with NFKBIA. Acetylation at Lys-310 is required for full transcriptional activity in the absence of effects on DNA binding and NFKBIA association. Acetylation can also lower DNA-binding and results in nuclear export. Interaction with BRMS1 promotes deacetylation of Lys-310. Lys-310 is deacetylated by SIRT2. PTM: S-nitrosylation of Cys-38 inactivates the enzyme activity (By similarity). PTM: Sulfhydration at Cys-38 mediates the anti-apoptotic activity by promoting the interaction with RPS3 and activating the transcription factor activity (By similarity). PTM: Sumoylation by PIAS3 negatively regulates DNA-bound activated NF-kappa-B. SIMILARITY: Contains 1 RHD (Rel-like) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RELAID325.html"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/rela/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q04206
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0019899 enzyme binding GO:0019901 protein kinase binding GO:0031490 chromatin DNA binding GO:0031625 ubiquitin protein ligase binding GO:0033613 activating transcription factor binding GO:0042301 phosphate ion binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0042805 actinin binding GO:0042826 histone deacetylase binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0044877 macromolecular complex binding GO:0046982 protein heterodimerization activity GO:0047485 protein N-terminus binding GO:0051059 NF-kappaB binding GO:0070491 repressing transcription factor binding GO:0071532 ankyrin repeat binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001889 liver development GO:0001942 hair follicle development GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0006117 acetaldehyde metabolic process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006952 defense response GO:0006954 inflammatory response GO:0006968 cellular defense response GO:0007568 aging GO:0008284 positive regulation of cell proliferation GO:0009612 response to mechanical stimulus GO:0009617 response to bacterium GO:0009887 animal organ morphogenesis GO:0010033 response to organic substance GO:0010035 response to inorganic substance GO:0010224 response to UV-B GO:0014040 positive regulation of Schwann cell differentiation GO:0014070 response to organic cyclic compound GO:0016032 viral process GO:0019221 cytokine-mediated signaling pathway GO:0031293 membrane protein intracellular domain proteolysis GO:0032332 positive regulation of chondrocyte differentiation GO:0032481 positive regulation of type I interferon production GO:0032495 response to muramyl dipeptide GO:0032496 response to lipopolysaccharide GO:0032570 response to progesterone GO:0032868 response to insulin GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033234 negative regulation of protein sumoylation GO:0033590 response to cobalamin GO:0034097 response to cytokine GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0035994 response to muscle stretch GO:0038095 Fc-epsilon receptor signaling pathway GO:0042177 negative regulation of protein catabolic process GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0043066 negative regulation of apoptotic process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043200 response to amino acid GO:0043278 response to morphine GO:0043620 regulation of DNA-templated transcription in response to stress GO:0045084 positive regulation of interleukin-12 biosynthetic process GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046627 negative regulation of insulin receptor signaling pathway GO:0050727 regulation of inflammatory response GO:0050852 T cell receptor signaling pathway GO:0050862 positive regulation of T cell receptor signaling pathway GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051591 response to cAMP GO:0051607 defense response to virus GO:0061614 pri-miRNA transcription from RNA polymerase II promoter GO:0070301 cellular response to hydrogen peroxide GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070498 interleukin-1-mediated signaling pathway GO:0070555 response to interleukin-1 GO:0071222 cellular response to lipopolysaccharide GO:0071223 cellular response to lipoteichoic acid GO:0071224 cellular response to peptidoglycan GO:0071316 cellular response to nicotine GO:0071347 cellular response to interleukin-1 GO:0071354 cellular response to interleukin-6 GO:0071356 cellular response to tumor necrosis factor GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901223 negative regulation of NIK/NF-kappaB signaling GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1904385 cellular response to angiotensin GO:2000630 positive regulation of miRNA metabolic process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
LF211173 - JP 2014500723-A/18676: Polycomb-Associated Non-Coding RNAs. BC110830 - Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog A (avian), mRNA (cDNA clone MGC:131774 IMAGE:6019711), complete cds. L19067 - Human NF-kappa-B transcription factor p65 subunit mRNA, complete cds. BC033522 - Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog A (avian), mRNA (cDNA clone MGC:34692 IMAGE:5162908), complete cds. BC011603 - Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog A (avian), mRNA (cDNA clone IMAGE:3139159), complete cds. BC014095 - Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog A (avian), mRNA (cDNA clone IMAGE:4547184), complete cds. BC069248 - Homo sapiens cDNA clone IMAGE:4123265, containing frame-shift errors. LF213818 - JP 2014500723-A/21321: Polycomb-Associated Non-Coding RNAs. JD518707 - Sequence 499731 from Patent EP1572962. JD204966 - Sequence 185990 from Patent EP1572962. LF344397 - JP 2014500723-A/151900: Polycomb-Associated Non-Coding RNAs. JD284608 - Sequence 265632 from Patent EP1572962. JD347198 - Sequence 328222 from Patent EP1572962. JD559280 - Sequence 540304 from Patent EP1572962. JD543595 - Sequence 524619 from Patent EP1572962. JD370131 - Sequence 351155 from Patent EP1572962. JD051702 - Sequence 32726 from Patent EP1572962. JD197615 - Sequence 178639 from Patent EP1572962. JD369025 - Sequence 350049 from Patent EP1572962. JD331536 - Sequence 312560 from Patent EP1572962. JD347501 - Sequence 328525 from Patent EP1572962. AK308478 - Homo sapiens cDNA, FLJ98519. JD114603 - Sequence 95627 from Patent EP1572962. JD437944 - Sequence 418968 from Patent EP1572962. JD149582 - Sequence 130606 from Patent EP1572962. JD253274 - Sequence 234298 from Patent EP1572962. JD226443 - Sequence 207467 from Patent EP1572962. JD554870 - Sequence 535894 from Patent EP1572962. JD560264 - Sequence 541288 from Patent EP1572962. AK303262 - Homo sapiens cDNA FLJ57698 complete cds, highly similar to Transcription factor p65. JD185756 - Sequence 166780 from Patent EP1572962. JD207871 - Sequence 188895 from Patent EP1572962. JD127014 - Sequence 108038 from Patent EP1572962. M62399 - Human NF-kappa-B transcription factor p65 DNA binding subunit mRNA, complete cds. AB464351 - Synthetic construct DNA, clone: pF1KB7855, Homo sapiens RELA gene for v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65, without stop codon, in Flexi system. AK308020 - Homo sapiens cDNA, FLJ97968. KJ901701 - Synthetic construct Homo sapiens clone ccsbBroadEn_11095 RELA gene, encodes complete protein. U33838 - Human NF-kappa-B p65delta3 mRNA, spliced transcript lacking exons 6 and 7, partial cds. CU679978 - Synthetic construct Homo sapiens gateway clone IMAGE:100020199 5' read RELA mRNA. KJ904547 - Synthetic construct Homo sapiens clone ccsbBroadEn_13941 RELA gene, encodes complete protein. LF344394 - JP 2014500723-A/151897: Polycomb-Associated Non-Coding RNAs. U88316 - Human NF-kappa-B transcription factor p65 mRNA, partial cds. MA579974 - JP 2018138019-A/151900: Polycomb-Associated Non-Coding RNAs. MA579971 - JP 2018138019-A/151897: Polycomb-Associated Non-Coding RNAs. MA446750 - JP 2018138019-A/18676: Polycomb-Associated Non-Coding RNAs. MA449395 - JP 2018138019-A/21321: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_cd40Pathway - CD40L Signaling Pathway h_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways h_ceramidePathway - Ceramide Signaling Pathway h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_rasPathway - Ras Signaling Pathway h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_nthiPathway - NFkB activation by Nontypeable Hemophilus influenzae h_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages h_keratinocytePathway - Keratinocyte Differentiation h_pkcPathway - Activation of PKC through G protein coupled receptor h_tnfr2Pathway - TNFR2 Signaling Pathway h_nfkbPathway - NF-kB Signaling Pathway h_atmPathway - ATM Signaling Pathway h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors h_mapkPathway - MAPKinase Signaling Pathway h_tollPathway - Toll-Like Receptor Pathway h_RELAPathway - Acetylation and Deacetylation of RelA in The Nucleus h_41bbPathway - The 4-1BB-dependent immune response h_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy h_cxcr4Pathway - CXCR4 Signaling Pathway h_gcrPathway - Corticosteroids and cardioprotection h_tall1Pathway - TACI and BCMA stimulation of B cell immune responses. h_tidPathway - Chaperones modulate interferon Signaling Pathway h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages h_il1rPathway - Signal transduction through IL1R h_pcafpathway - The information-processing pathway at the IFN-beta enhancer h_rnaPathway - Double Stranded RNA Induced Gene Expression h_stressPathway - TNF/Stress Related Signaling h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_freePathway - Free Radical Induced Apoptosis h_ranklPathway - Bone Remodelling h_tcrPathway - T Cell Receptor Signaling Pathway h_aktPathway - AKT Signaling Pathway h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition h_eponfkbPathway - Erythropoietin mediated neuroprotection through NF-kB
Reactome (by CSHL, EBI, and GO)
Protein Q04206 (Reactome details) participates in the following event(s):
R-HSA-5660980 p-S276-RELA binds RELB R-HSA-168166 NFkB complex is transported from cytosol to nucleus R-HSA-168140 Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex R-HSA-193691 NF-kB migrates to the nucleus and turns on transcription R-HSA-193700 p75NTR ICD signals to NF-kB R-HSA-193705 IKKbeta phosphorylates IkB causing NF-kB to dissociate R-HSA-209125 SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex R-HSA-8865237 SETD6 methylates RELA in the NFkB complex R-HSA-3857305 Activated CEBPB and NFKB complex bind IL6 promoter R-HSA-3857308 Activated CEBPB and NFKB complex bind IL8 promoter R-HSA-5624473 Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit R-HSA-5660666 CBP and p300 binds NF-kB complex R-HSA-202541 p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB R-HSA-209063 Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex R-HSA-5660660 p300 acetylates RELA subunit R-HSA-1168638 Activated IKK phosphorylates I-kappaB R-HSA-1168642 SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-933542 TRAF6 mediated NF-kB activation R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-209560 NF-kB is activated and signals survival R-HSA-193692 Regulated proteolysis of p75NTR R-HSA-202424 Downstream TCR signaling R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-9020702 Interleukin-1 signaling R-HSA-3214841 PKMTs methylate histone lysines R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-5603029 IkBA variant leads to EDA-ID R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975871 MyD88 cascade initiated on plasma membrane R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-193639 p75NTR signals via NF-kB R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-202403 TCR signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-446652 Interleukin-1 family signaling R-HSA-3247509 Chromatin modifying enzymes R-HSA-2559583 Cellular Senescence R-HSA-168249 Innate Immune System R-HSA-5602358 Diseases associated with the TLR signaling cascade R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168898 Toll-Like Receptors Cascades R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-73887 Death Receptor Signalling R-HSA-1280218 Adaptive Immune System R-HSA-449147 Signaling by Interleukins R-HSA-4839726 Chromatin organization R-HSA-2262752 Cellular responses to stress R-HSA-168256 Immune System R-HSA-5260271 Diseases of Immune System R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-983705 Signaling by the B Cell Receptor (BCR) R-HSA-162582 Signal Transduction R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-8953897 Cellular responses to external stimuli R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
