ID:RGRF2_HUMAN DESCRIPTION: RecName: Full=Ras-specific guanine nucleotide-releasing factor 2; Short=Ras-GRF2; AltName: Full=Ras guanine nucleotide exchange factor 2; FUNCTION: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. SUBUNIT: Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1. Interacts in a calcium-dependent manner with calmodulin (By similarity). Interacts with CDK5R1 and EPB49. Interacts with the AMPA receptor through GRIA1 (By similarity). Interacts with microtubules (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). TISSUE SPECIFICITY: Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level). DOMAIN: The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation (By similarity). DOMAIN: The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the Ras-GEF activity (By similarity). DOMAIN: The DH (DBL-homology) domain mediates interaction with RASGRF1 and EPB49 and is required for RAC1 activation. PTM: Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation. PTM: Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome (By similarity). SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 IQ domain. SIMILARITY: Contains 1 N-terminal Ras-GEF domain. SIMILARITY: Contains 2 PH domains. SIMILARITY: Contains 1 Ras-GEF domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14827
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0007186 G-protein coupled receptor signaling pathway GO:0007264 small GTPase mediated signal transduction GO:0034976 response to endoplasmic reticulum stress GO:0035023 regulation of Rho protein signal transduction GO:0043065 positive regulation of apoptotic process GO:0046578 regulation of Ras protein signal transduction GO:0051056 regulation of small GTPase mediated signal transduction
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
